Immune Infertility: The Impact of Immune Reactions on Human Infertility / Edition 1

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This comprehensive overview of immune reactions inducing fertility disorders in both sexes first describes the nature and the function of sperm antigens which are capable to induce immune infertility as well as the methods to analyse and characterize these antigens. Secondly, the nature, the origin and induction of antisperm antibodies (ASA) in both sexes and the role of reproductive organs and their interaction with the immune system will be discussed. A large section of the book, which is most important for clinicians working in reproductive medicine, deals with the clinical impact of the immune reaction in reproductive medicine, including the methods of determination and the treatment in immune infertility. Closely related to immune infertility is the development of immune contraceptives which is also discussed.

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Editorial Reviews

From The Critics
Reviewer: Irvin H Hirsch, MD (Thomas Jefferson University)
Description: In this first book devoted entirely to the subject of immunologic infertility, 19 chapters cover its impact, diagnosis, and treatment.
Purpose: The authors synthesize the contemporary advances in the fields of genomics, proteomics, and immune mechanisms as applied to sperm morphology, physiology, and diagnostic techniques for sperm autoantibody infertility. These efforts have clarified much of the confusion surrounding the incidence and relevance of sperm-mediated immunity as a factor in human infertility.
Audience: The authors direct their work to clinicians, scientists, trainees in reproductive biology, obstetricians/gynecologists, and urologists. Clinical embryologists and specialists in reproductive endocrinology also will find in this work a vital compendium of developments in the area of immunoinfertility.
Features: The book comprehensively courses through the basic science of sperm autoimmunity, its contemporary laboratory diagnosis, and its treatment. In addition, an entire section is devoted to advances in immunocontraception. This highly specialized field is clearly depicted with the aid of graphs, tables, schematic diagrams, and exquisite photomicrographs. The addition of sperm proteomics and analysis of sperm antigens is a distinguishing feature of this work.
Assessment: This is a unique, comprehensive, and cogent update of basic and therapeutic advances in the field of immunoinfertility. Students, clinicians, and researchers will appreciate the application of the latest bioscientific techniques to this subject and the increasing clarity this diagnosis has achieved.
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Product Details

  • ISBN-13: 9783642013782
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 10/23/2009
  • Edition description: 2009
  • Edition number: 1
  • Pages: 236
  • Product dimensions: 6.30 (w) x 9.40 (h) x 0.60 (d)

Table of Contents

Sperm Antigens.- Proteomics of Human Spermatozoa.- Methods of Analysis of Sperm Antigens Related to Fertility.- Sperm Surface Proteomics.- Sperm Functions Influenced by Immune Reactions.- Antisperm Antibodies (ASA).- The Immune Privilege of the Testis.- Immune Chemistry of ASA.- Sperm-Specific T Lymphocytes.- Site and Risk Factors of Antisperm Antibodies Production in the Male Population.- Biologic Substrates Containing ASA.- ASA in the Female.- Sperm-Immobilizing Antibody and Its Target Antigen (CD52).- The Clinical Impact of Sperm Antibodies.- Male Autoimmune Infertility.- Tests for Sperm Antibodies.- Impact on Fertility Outcome.- Sperm Antibodies and Assisted Reproduction.- Treatment of Immune Infertility.- Immune Contraception.- Immunization with Sperm Antigens to Induce Contraception.- Immunocontraception in Wildlife Animals.- Experience from Clinical Trials with Fertility Control Vaccines.

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