Immune Infertility: The Impact of Immune Reactions on Human Infertility / Edition 1

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Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2–30% of infertility. The sperm has both autoantigenic as well as isoantigenic potential, and is thus capable of p- ducing antisperm antibodies (ASAs) and sperm-reactive T cells in both infertile men and women. Also, over 75% vasectomized men produce autoantibodies to sperm that can cause a problem in regaining fertility even after successful re-anastomosis in vasovasostomy. Early claims regarding the incidence and involvement of ASAs in involuntary human infertility were probably overemphasized because of unreliable techniques and naivety concerning the complexity of the immune response and antigenic nature of the sperm cell. These factors, the lack of well-designed and controlled experimental studies, and the dearth of effective therapeutic modalities resulted in the confusion of the occurrence and importance of ASAs in human infertility. Consequently, evaluation of infertile couples for ASAs and their possible role in infertility was not considered a signifcant proposition. The development of more accurate assays and the discovery of mucosal immunity capable of responses independent of systemic immunity have caused inclusion of sperm cells and genital tract secretions in the analysis of ASAs.
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Editorial Reviews

Doody's Review Service
Reviewer: Irvin H Hirsch, MD (Thomas Jefferson University)
Description: In this first book devoted entirely to the subject of immunologic infertility, 19 chapters cover its impact, diagnosis, and treatment.
Purpose: The authors synthesize the contemporary advances in the fields of genomics, proteomics, and immune mechanisms as applied to sperm morphology, physiology, and diagnostic techniques for sperm autoantibody infertility. These efforts have clarified much of the confusion surrounding the incidence and relevance of sperm-mediated immunity as a factor in human infertility.
Audience: The authors direct their work to clinicians, scientists, trainees in reproductive biology, obstetricians/gynecologists, and urologists. Clinical embryologists and specialists in reproductive endocrinology also will find in this work a vital compendium of developments in the area of immunoinfertility.
Features: The book comprehensively courses through the basic science of sperm autoimmunity, its contemporary laboratory diagnosis, and its treatment. In addition, an entire section is devoted to advances in immunocontraception. This highly specialized field is clearly depicted with the aid of graphs, tables, schematic diagrams, and exquisite photomicrographs. The addition of sperm proteomics and analysis of sperm antigens is a distinguishing feature of this work.
Assessment: This is a unique, comprehensive, and cogent update of basic and therapeutic advances in the field of immunoinfertility. Students, clinicians, and researchers will appreciate the application of the latest bioscientific techniques to this subject and the increasing clarity this diagnosis has achieved.
From the Publisher
From the reviews:

“The authors direct their work to clinicians, scientists, trainees in reproductive biology, obstetricians/gynecologists, and urologists. … This highly specialized field is clearly depicted with the aid of graphs, tables, schematic diagrams, and exquisite photomicrographs. … This is a unique, comprehensive, and cogent update of basic and therapeutic advances in the field of immunoinfertility.” (Irvin H. Hirsch, Doody’s Review Service, December, 2009)

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Product Details

  • ISBN-13: 9783642013782
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 9/9/2009
  • Edition description: 2009
  • Edition number: 1
  • Pages: 236
  • Product dimensions: 6.30 (w) x 9.40 (h) x 0.60 (d)

Table of Contents

Sperm Antigens.- Proteomics of Human Spermatozoa.- Methods of Analysis of Sperm Antigens Related to Fertility.- Sperm Surface Proteomics.- Sperm Functions Influenced by Immune Reactions.- Antisperm Antibodies (ASA).- The Immune Privilege of the Testis.- Immune Chemistry of ASA.- Sperm-Specific T Lymphocytes.- Site and Risk Factors of Antisperm Antibodies Production in the Male Population.- Biologic Substrates Containing ASA.- ASA in the Female.- Sperm-Immobilizing Antibody and Its Target Antigen (CD52).- The Clinical Impact of Sperm Antibodies.- Male Autoimmune Infertility.- Tests for Sperm Antibodies.- Impact on Fertility Outcome.- Sperm Antibodies and Assisted Reproduction.- Treatment of Immune Infertility.- Immune Contraception.- Immunization with Sperm Antigens to Induce Contraception.- Immunocontraception in Wildlife Animals.- Experience from Clinical Trials with Fertility Control Vaccines.
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