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Doody's Review ServiceReviewer: Irvin H Hirsch, MD (Thomas Jefferson University)
Description: In this first book devoted entirely to the subject of immunologic infertility, 19 chapters cover its impact, diagnosis, and treatment.
Purpose: The authors synthesize the contemporary advances in the fields of genomics, proteomics, and immune mechanisms as applied to sperm morphology, physiology, and diagnostic techniques for sperm autoantibody infertility. These efforts have clarified much of the confusion surrounding the incidence and relevance of sperm-mediated immunity as a factor in human infertility.
Audience: The authors direct their work to clinicians, scientists, trainees in reproductive biology, obstetricians/gynecologists, and urologists. Clinical embryologists and specialists in reproductive endocrinology also will find in this work a vital compendium of developments in the area of immunoinfertility.
Features: The book comprehensively courses through the basic science of sperm autoimmunity, its contemporary laboratory diagnosis, and its treatment. In addition, an entire section is devoted to advances in immunocontraception. This highly specialized field is clearly depicted with the aid of graphs, tables, schematic diagrams, and exquisite photomicrographs. The addition of sperm proteomics and analysis of sperm antigens is a distinguishing feature of this work.
Assessment: This is a unique, comprehensive, and cogent update of basic and therapeutic advances in the field of immunoinfertility. Students, clinicians, and researchers will appreciate the application of the latest bioscientific techniques to this subject and the increasing clarity this diagnosis has achieved.