The Immune Response to Infection

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Overview

Examines the mechanisms of both the innate and adaptive immune systems as they relate to infection and disease.

  • Explores the underlying mechanisms of immunity and the many sequelae of host-pathogen interactions, ranging from the sterile eradication of the invader, to controlled chronic infection, to pathologic corollaries of the host-pathogen crosstalk.
  • Discusses the pathogenesis of certain autoimmune disorders and cancers that are induced by infectious agents but then become independent of the infection process.
  • Serves as a resource for immunologists, molecular microbiologists, infectious disease clinicians, researchers, and students.


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Editorial Reviews

Doody's Review Service
Reviewer: Patricia Fitzgerald-Bocarsly, PhD (University of Medicine and Dentistry of New Jersey-NJMS)
Description: This comprehensive book details the advances in our understanding of innate and adaptive immune responses to infectious organisms, and how these advances are leading to novel therapeutic intervention strategies for infectious diseases and their associated pathologies. Written by distinguished experts, this book is divided into nine sections ranging from general aspects of host defense to specific acquired immunity, immunopathology, and immune intervention.
Purpose: The editors' stated purpose is to provide a comprehensive update on infectious disease immunology. Given the exponential rate at which knowledge has been expanding in the study of host response to infection, and the fact that previous books addressing similar topics are sorely out of date, this is a much-needed resource.
Audience: Their goal is to provide a holistic approach to the study of host/pathogen interactions, thus bringing together the fields of microbiology and immunology. While this book will be best appreciated by professional immunologists, it also will be useful for traditional microbiologists who want a better understanding of host/pathogen interactions as well as for advanced students of immunology who want a comprehensive compilation covering the field.
Features: The book begins with fascinating descriptions of invertebrate immunity to infectious organisms and evolution of the immune response and chapters on the different categories of pathogens, then carries on through innate and adaptive immune responses to these distinct categories of pathogens. These are followed by important sections on the pathology of infections and pathogen evasion of host response, and autoimmunity, and chapters on immune intervention that document the outstanding progress that is being made in the field. The book ends on the more humbling note of four specific infectious diseases — HIV, TB, malaria, and flu — that are still causing huge worldwide morbidity and mortality despite extensive, ongoing research efforts. Overall, the book is informative and comprehensive. Somewhat disappointing, however, is the lack of color figures; color is limited to a small number of color plates clustered together in the center of the book, where their separation from the relevant text limits their value.
Assessment: This is an outstanding and comprehensive overview of our current knowledge of the immune response to infection. Although excellent books like Immunology of Infectious Diseases, also edited by Kaufmann (ASM Press, 2002), precede it, these are already too outdated to be of much current use. In addition, although there are many other books that address some of the topics in this book, this comprehensive publication has the potential to be for infectious disease immunology what Fields Virology is for virology.
From The Critics
Reviewer: Patricia Fitzgerald-Bocarsly, PhD (University of Medicine and Dentistry of New Jersey-NJMS)
Description: This comprehensive book details the advances in our understanding of innate and adaptive immune responses to infectious organisms, and how these advances are leading to novel therapeutic intervention strategies for infectious diseases and their associated pathologies. Written by distinguished experts, this book is divided into nine sections ranging from general aspects of host defense to specific acquired immunity, immunopathology, and immune intervention.
Purpose: The editors' stated purpose is to provide a comprehensive update on infectious disease immunology. Given the exponential rate at which knowledge has been expanding in the study of host response to infection, and the fact that previous books addressing similar topics are sorely out of date, this is a much-needed resource.
Audience: Their goal is to provide a holistic approach to the study of host/pathogen interactions, thus bringing together the fields of microbiology and immunology. While this book will be best appreciated by professional immunologists, it also will be useful for traditional microbiologists who want a better understanding of host/pathogen interactions as well as for advanced students of immunology who want a comprehensive compilation covering the field.
Features: The book begins with fascinating descriptions of invertebrate immunity to infectious organisms and evolution of the immune response and chapters on the different categories of pathogens, then carries on through innate and adaptive immune responses to these distinct categories of pathogens. These are followed by important sections on the pathology of infections and pathogen evasion of host response, and autoimmunity, and chapters on immune intervention that document the outstanding progress that is being made in the field. The book ends on the more humbling note of four specific infectious diseases — HIV, TB, malaria, and flu — that are still causing huge worldwide morbidity and mortality despite extensive, ongoing research efforts. Overall, the book is informative and comprehensive. Somewhat disappointing, however, is the lack of color figures; color is limited to a small number of color plates clustered together in the center of the book, where their separation from the relevant text limits their value.
Assessment: This is an outstanding and comprehensive overview of our current knowledge of the immune response to infection. Although excellent books like Immunology of Infectious Diseases, also edited by Kaufmann (ASM Press, 2002), precede it, these are already too outdated to be of much current use. In addition, although there are many other books that address some of the topics in this book, this comprehensive publication has the potential to be for infectious disease immunology what Fields Virology is for virology.
From The Critics
Reviewer:This is an outstanding and comprehensive overview of our current knowledge of the immune response to infection. Although excellent books like Immunology of Infectious Diseases, also edited by Kaufmann (ASM Press, 2002), precede it, these are already too outdated to be of much current use. In addition, although there are many other books that address some of the topics in this book, this comprehensive publication has the potential to be for infectious disease immunology what Fields Virology is for virology.
Description:
Purpose:This comprehensive book details the advances in our understanding of innate and adaptive immune responses to infectious organisms, and how these advances are leading to novel therapeutic intervention strategies for infectious diseases and their associated pathologies. Written by distinguished experts, this book is divided into nine sections ranging from general aspects of host defense to specific acquired immunity, immunopathology, and immune intervention.
Audience:The editors' stated purpose is to provide a comprehensive update on infectious disease immunology. Given the exponential rate at which knowledge has been expanding in the study of host response to infection, and the fact that previous books addressing similar topics are sorely out of date, this is a much-needed resource.
Features:Their goal is to provide a holistic approach to the study of host/pathogen interactions, thus bringing together the fields of microbiology and immunology. While this book will be best appreciated by professional immunologists, it also will be useful for traditional microbiologists who want a better understanding of host/pathogen interactions as well as for advanced students of immunology who want a comprehensive compilation covering the field.
Assessment:The book begins with fascinating descriptions of invertebrate immunity to infectious organisms and evolution of the immune response and chapters on the different categories of pathogens, then carries on through innate and adaptive immune responses to these distinct categories of pathogens. These are followed by important sections on the pathology of infections and pathogen evasion of host response, and autoimmunity, and chapters on immune intervention that document the outstanding progress that is being made in the field. The book ends on the more humbling note of four specific infectious diseases — HIV, TB, malaria, and flu — that are still causing huge worldwide morbidity and mortality despite extensive, ongoing research efforts. Overall, the book is informative and comprehensive. Somewhat disappointing, however, is the lack of color figures; color is limited to a small number of color plates clustered together in the center of the book, where their separation from the relevant text limits their value.
From The Critics
Reviewer: Patricia Fitzgerald-Bocarsly, PhD(University of Medicine and Dentistry of New Jersey-NJMS)
Description: This comprehensive book details the advances in our understanding of innate and adaptive immune responses to infectious organisms, and how these advances are leading to novel therapeutic intervention strategies for infectious diseases and their associated pathologies. Written by distinguished experts, this book is divided into nine sections ranging from general aspects of host defense to specific acquired immunity, immunopathology, and immune intervention.
Purpose: The editors' stated purpose is to provide a comprehensive update on infectious disease immunology. Given the exponential rate at which knowledge has been expanding in the study of host response to infection, and the fact that previous books addressing similar topics are sorely out of date, this is a much-needed resource.
Audience: Their goal is to provide a holistic approach to the study of host/pathogen interactions, thus bringing together the fields of microbiology and immunology. While this book will be best appreciated by professional immunologists, it also will be useful for traditional microbiologists who want a better understanding of host/pathogen interactions as well as for advanced students of immunology who want a comprehensive compilation covering the field.
Features: The book begins with fascinating descriptions of invertebrate immunity to infectious organisms and evolution of the immune response and chapters on the different categories of pathogens, then carries on through innate and adaptive immune responses to these distinct categories of pathogens. These are followed by important sections on the pathology of infections and pathogen evasion of host response, and autoimmunity, and chapters on immune intervention that document the outstanding progress that is being made in the field. The book ends on the more humbling note of four specific infectious diseases — HIV, TB, malaria, and flu — that are still causing huge worldwide morbidity and mortality despite extensive, ongoing research efforts. Overall, the book is informative and comprehensive. Somewhat disappointing, however, is the lack of color figures; color is limited to a small number of color plates clustered together in the center of the book, where their separation from the relevant text limits their value.
Assessment: This is an outstanding and comprehensive overview of our current knowledge of the immune response to infection. Although excellent books like Immunology of Infectious Diseases, also edited by Kaufmann (ASM Press, 2002), precede it, these are already too outdated to be of much current use. In addition, although there are many other books that address some of the topics in this book, this comprehensive publication has the potential to be for infectious disease immunology what Fields Virology is for virology.
Read More Show Less

Product Details

  • ISBN-13: 9781555815141
  • Publisher: ASM Press
  • Publication date: 11/30/2010
  • Edition description: New Edition
  • Pages: 666
  • Product dimensions: 8.60 (w) x 11.00 (h) x 1.40 (d)

Table of Contents

Table of Contents

Immunology of Infectious Diseases: Introduction, Stefan H. E. Kaufmann, Barry Rouse, and David Sacks

I. HOST DEFENSE: GENERAL

1. Invertebrate Innate Immune Defenses, Laure El Chamy, Charles Hetru, and Jules Hoffmann
2. The Ontogeny of the Cells of the Innate and the Adaptive Immune System, Fritz Melchers
3. The Evolutionary Origins of the Adaptive Immune System of Jawed Vertebrates, Jim Kaufman
4. Host Defense (Antimicrobial) Peptides and Proteins, Laurence Madera, Shuhua Ma, and Robert E. W. Hancock
5. Reactive Oxygen and Reactive Nitrogen Intermediates in the Immune System, Christian Bogdan
6. Complement in Infections, Wilhelm J. Schwaeble, Youssif Mohammed Ali, Nicholas J. Lynch, and Russell Wallis
7. Immune Defense at Mucosal Surfaces, Marian R. Neutra and Jean-Pierre Kraehenbuhl
8. Regulation of Antimicrobial Immunity, Yasmine Belkaid, Sharvan Sehrawat, and Barry T. Rouse
9. Memory and Infection, David Masopust and Mark K. Slifka

II. THE PATHOGENS

10. Overview on the Viral Pathogens, Jonathan W. Yewdell and Jack R. Bennink
11. Overview of Parasitic Pathogens, Rick L. Tarleton and Edward J. Pearce
12. Overview of Bacterial Pathogens, Philippe J. Sansonetti and Andrea Puhar
13. Overview of Fungal Pathogens, Axel A. Brakhage and Peter F. Zipfel
14. Prionoses and the Immune System, Jürgen A. Richt and Alan Young

III. INNATE IMMUNITY TO MICROBIAL INFECTIONS

15. Innate Immunity to Viruses, Akiko Iwasaki
16. Natural Killer Cell Response against Viruses, Joseph C. Sun and Lewis L. Lanier
17. Innate Immunity against Bacteria, Thomas Areschoug, Annetete Plüddemann, and Siamon Gordon
18. Innate Immunity to Parasitic Infections, Christopher A. Hunter and Alan Sher

IV. ACQUIRED IMMUNITY TO MICROBIAL INFECTIONS

19. Acquired Immunity against Virus Infections, Eva Szomolanyi-Tsuda, Michael A. Brehm, and Raymond M. Welsh
20. Immune Responses to Persistent Viruses, E. John Wherry and Paul Klenerman
21. Acquired Immunity: Acute Bacterial Infections, Dennis W. Metzger
22. Acquired Immunity: Chronic Bacterial Infections, Andrea M. Cooper and Richard Robinson
23. Acquired Immunity: Fungal Infections, Luigina Romani
24. Acquired Immunity to Intracellular Protozoa, Phillip Scott and Eleanor M. Riley
25. Acquired Immunity to Helminths, David Artis and Rick M. Maizels

V. PATHOLOGY AND PATHOGENESIS

26. Pathology and Pathogenesis of Bacterial Infections, Warwick J. Britton and Bernadette M. Saunders

27. Helicobacter pylori: the Role of the Immune Response in Pathogenesis, Karen Robinson and John C. Atherton

28. Pathogenesis of Helminth Infections, Thomas A. Wynn and Judith E. Allen

29. Pathology and Pathogenesis of Malaria, Chanaki Amaratunga, Tatiana M. Lopera-Mesa, Jeanette G. Tse, Neida K. Mita-Mendoza, and Rick M. Fairhurst

30. Pathology and Pathogenesis of Virus Infections, Carmen Baca Jones and Matthias von Herrath

VI. EVASION AND SUPPRESSION OF THE ANTIMICROBIAL HOST RESPONSE

31. Viral Immune Invasion, Lila Farrington, Gabriela O’Neill, and Ann B. Hill

32. Growing Old and Immunity to Viruses, Janko Nikolich-Zugich and Marcia A. Blackman

33. Growing Old and Immunity to Bacteria, Joanne Turner

34. Bacterial Strategies for Survival in the Host, Anna D. Tischler and John D. McKinney

35. Suppression of Immune Responses to Protozoan Parasites, David L. Sacks

36. Immune Evasion by Parasites, John M. Mansfield and Martin Olivier

VII. GENETICS OF THE ANTIMICROBIAL HOST RESPONSE

37. Genetics of Antibacterial Host Defenses, Steven M. Holland

38. Immunogenetics of Host Response to Parasites in Humans, Jenefer M. Blackwell

39. Immunogenetics of Virus Pathogenesis, Sean Wiltshire, David I. Watkins, Emil Skamene, and Silvia Vidal

VIII. AUTOIMMUNITY AND CANCER

40. Viruses, Autoimmunity, and Cancer, Meghann Teague Getts, Lies Bogaert, W. Martin Kast, and Stephen D. Miller

41. The Role of Bacterial and Parasitic Infections in Chronic Inflammatory Disorders and Autoimmunity, Stefan Ehlers and Graham A. W. Rook

42. Theileria-Induced Leukocyte Transformation: an Example of Oncogene Addiction? Marie Chaussepied and Gordon Langsley

IX. IMMUNE INTERVENTION

43. Systems Vaccinology: Using Functional Signatures To Design Successful Vaccines, Troy D. Querec and Bali Pulendran

44. Meeting the Challenge of Vaccine Design To Control HIV and Other Difficult Viruses, Barney S. Graham and Christopher Walker

45. Immune Intervention Strategies Against Tuberculosis, Peter Andersen and Stefan H. E. Kaufmann

46. Immune Intervention in Malaria, Carole A. Long and Fidel P. Zavala

47. Targeting Components in Vector Saliva, Mary Ann McDowell and Shaden Kamhawi

X. THE MAJOR KILLERS (Clinics, Epidemiology, Immune Parameters)

48. AIDS Vaccines: the Unfolding Story, Stephen Norley

49. Tuberculosis, Gerhard Walzl, Paul van Helden, and Philip R. Botha

50. Malaria: Clinical and Epidemiological Aspects, Andrea A. Berry, Myaing M. Nyunt, and Christopher V. Plowe

51. The Epidemiology and Immunology of Influenza Viruses, Rafael A. Medina, Irene Ramos, and Ana Fernandez-Sesma

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