Immunobiology: The Immune System in Health and Disease

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Immunobiology: The Immune System in Health and Disease is the current, authoritative introductory immunology textbook that leads the way into the 21st century. It is cutting-edge, definitive and lucid. Now in its Fourth Edition, Immunobiology has been used by over 100,000 undergraduates, post-graduates, medical students, and researchers. Immunobiology presents the field of immunology from the viewpoint of the host's response to infection.

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Overview

Immunobiology: The Immune System in Health and Disease is the current, authoritative introductory immunology textbook that leads the way into the 21st century. It is cutting-edge, definitive and lucid. Now in its Fourth Edition, Immunobiology has been used by over 100,000 undergraduates, post-graduates, medical students, and researchers. Immunobiology presents the field of immunology from the viewpoint of the host's response to infection.

NEW FEATURES AND UPDATES:

The new 'Signaling through Lymphocyte Receptors' chapter is a reorganization, clarification, and expansion of the B-cell and T-cell signaling information presented in the previous edition. It includes information on:

  • newly understood cytokine signaling pathways.
  • how signals 'switch off' some immunological pathways.
  • cell death-regulating signaling pathways.
  • how signaling maintains lymphocyte homeostasis.
  • The 'Antigen Recognition by T Lymphocytes' chapter has been fully updated to include new information and illustrations such as the structural detail of TCR-MHC interactions. It also includes antigen processing by MHC class I and II, and how viruses interfere with these pathways.
  • New information on cytokines and chemokines reflecting current research interests.
  • Updates on transplant rejection including a new section on chronic organ rejection.

SPECIAL FEATURES OF PEDAGOGICAL VALUE:

  • Easy to understand and assimilate full-color figures using distinct iconography, including new icons to illustrate signaling pathways such as cytoplasmic kinases and transcription factors.
  • New user-friendly book style and easy to use sequential pagination.
  • New-look cover.
  • Fully up to date and informative CD antigen table.
  • Cytokine summary table.
  • Chemokine summary table.
  • At-a-glance biographies of notable immunologists.
  • Extensive glossary.

The book contains predominantly color illustrations, with some black-and-white illustrations.

A textbook that keeps pace with the fast-changing field of immunology.

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Editorial Reviews

Marion C. Cohen
This is the fourth edition of a basic textbook of immunology authored by four well-known researchers in the field. The previous edition was published in 1997. As in previous editions, the purpose is to function as an introductory text for medical students, advanced undergraduate biology students, and graduate students. It is an up-to-date—at least up to the time of publication—overview of the field that would be useful not only to the students for whom it was targeted but also for researchers who need some specific information in some aspect of immunology with which they have little familiarity. The book is aimed at medical students, graduate students, and some undergraduates. The authors are considered experts in the specific areas in which they wrote chapters and there is no question of their capability in providing good overviews. Almost all aspects of immunology are described. An obvious deficiency is the lack of a chapter on the evolution of immunology. It is very clearly written but probably requires some familiarity with the subject's arcane language. It is not likely that most students would be capable of learning immunology from this book alone, but it is an excellent supplement to lectures. The figures are particularly good and they are available on a CD-ROM for purchase. The format follows previous editions, starting with basic immunology and going on to immunopathology. A chapter on signaling has been added. References for each chapter have been included. There are three appendixes: the CD antigens, cytokines and their receptors, and chemokines and their receptors. A glossary is also included. The use of color in the figures is very attractive. Thistextbook has been fine-tuned as it has gone through its various editions. It is an excellent source of information for advanced students. There is a lot of material packed into it that may scare away students who want to learn only the minimum required for exams. There are several texts written at this level and this one compares favorably to them. Immunology changes so fast that this updated edition should be well received.
From The Critics
Reviewer: Marion C. Cohen, PhD (University of Medicine and Dentistry of New Jersey-NJMS)
Description: This is the fourth edition of a basic textbook of immunology authored by four well-known researchers in the field. The previous edition was published in 1997.
Purpose: As in previous editions, the purpose is to function as an introductory text for medical students, advanced undergraduate biology students, and graduate students. It is an up-to-date:at least up to the time of publication:overview of the field that would be useful not only to the students for whom it was targeted but also for researchers who need some specific information in some aspect of immunology with which they have little familiarity.
Audience: The book is aimed at medical students, graduate students, and some undergraduates. The authors are considered experts in the specific areas in which they wrote chapters and there is no question of their capability in providing good overviews.
Features: Almost all aspects of immunology are described. An obvious deficiency is the lack of a chapter on the evolution of immunology. It is very clearly written but probably requires some familiarity with the subject's arcane language. It is not likely that most students would be capable of learning immunology from this book alone, but it is an excellent supplement to lectures. The figures are particularly good and they are available on a CD-ROM for purchase. The format follows previous editions, starting with basic immunology and going on to immunopathology. A chapter on signaling has been added. References for each chapter have been included. There are three appendixes: the CD antigens, cytokines and their receptors, and chemokines and their receptors. A glossary is also included. The use of color in the figures is very attractive.
Assessment: This textbook has been fine-tuned as it has gone through its various editions. It is an excellent source of information for advanced students. There is a lot of material packed into it that may scare away students who want to learn only the minimum required for exams. There are several texts written at this level and this one compares favorably to them. Immunology changes so fast that this updated edition should be well received.
From The Critics
This textbook is intended for introductory immunology courses for medical students, advanced undergraduate biology students, or graduate students. It covers immunobiology and innate immunity, the recognition of antigen, the development of mature lymphocyte receptor repertoires, the adaptive immune response, the immune system in health and disease, and the evolution of the immune system. A companion CD-ROM contains 27 animations. The authors are affiliated with Yale University, the Imperial College School of Medicine, and the Anthony Nolan Research Institute. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Booknews
**** An annual reference for those who seek state legislative information (e.g., the status of a bill, biographical information on a legislator, a description of a state's legislative process, how to get a copy of a bill), cited in ARBA 1993 and the Supplement to Sheehy. This updated edition (the 11th) adds key Internet sites and e-mail addresses. It also marks a change from the old 3-ring binder to a new soft cover format. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780815316916
  • Publisher: Taylor & Francis
  • Publication date: 11/28/1994
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 590
  • Product dimensions: 8.00 (w) x 10.00 (h) x 2.00 (d)

Table of Contents

Pt. I An introduction to immunobiology and innate immunity
Ch. 1 Basic concepts in immunology 1
Ch. 2 Innate immunity 37
Pt. II The recognition of antigen
Ch. 3 Antigen recognition by B-cell and T-cell receptors 103
Ch. 4 The generation of lymphocyte antigen receptors 135
Ch. 5 Antigen presentation to T lymphocytes 169
Pt. III The development of mature lymphocyte receptor repertoires
Ch. 6 Signaling through immune system receptors 203
Ch. 7 The development and survival of lymphocytes 241
Pt. IV The adaptive immune response
Ch. 8 T cell-mediated immunity 319
Ch. 9 The humoral immune response 367
Ch. 10 Adaptive immunity to infection 409
Pt. V The immune system in health and disease
Ch. 11 Failures of host defense mechanisms 461
Ch. 12 Allergy and hypersensitivity 517
Ch. 13 Autoimmunity and transplantation 557
Ch. 14 Manipulation of the immune response 613
Pt. VI The origins of immune responses
Ch. 15 Evolution of the immune system 665
App. I Immunologists' toolbox 683
App. II CD antigens 731
App. III Cytokines and their receptors 747
App. IV Chemokines and their receptors 750
App. V Immunological constants 751
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