Immunodeficient Animals: Models for Cancer Research / Edition 1

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Overview

The classic immunodeficient mutants nude, scid and rnu have an important function in experimental cancer research: they allow unique methods of investigation and provide data of clinical relevance. This volume presents the state of the art of research work based on the use of these immunodeficient animal models. One section is dedicated to the biological aspects and immunological properties of immunodeficient mutants. Another part includes articles on xenogenous transplantation of human tumors, focusing on the establishment of transplantable lines, growth characteristics and tumor markers. Special attention is given to new approaches in the fields of chemotherapy, radiation therapy and immunotherapy. Various contributors consider in vitro methods as alternative models. In addition to current data, this publication contains useful technical and methodological information and is therefore valuable not only for specialists but also for scientists entering the field of experimental cancer research.
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Table of Contents

Introduction: Immunodeficient Animals - Still Important Tools for Cancer Research
Thermoregulation in Athymic and Euthymic Hairless Mice 1
Five-Year Breeding Data, Immunology, and Tumor Take Rates of an NMRI Nude Mouse Colony 12
Ultrastructural Aspects of Thymic Dysgenesis in Nude Mice 19
Phenotyping of Lymphocytes in Hetero- and Homozygous Athymic NMRI Nude Mice by Computerized Two-Colored Flow-Cytometric Analysis 23
Cellular Response to Sheep Red Blood Cells on the Omentum of Nude Mice 28
Iodine-Induced Expression of Immunoglobulin Supergene Family in Normal Human Thyroid Tissue in vivo 32
HMGI-Effected Gene Transfer Using Cell Cultures and Tissue Explants Xenografted in Immunodeficient Mice 36
Frequent Occurrence of Spontaneous Tumors in NMRI Athymic Nude Mice 41
Orthotopic Implantation in Nude Mice: A Metastatic Model for Human Prostate Cancer 45
Establishment of Seven New Human Prostatic Tumor Lines in NMRI Athymic Nude Mice 49
Intraperitoneal Transplantation of Human Ovarian Carcinoma Xenografts in Thymus Aplastic Nude Mice 52
Establishment and Characterization of Human Sarcoma Lines Transplanted into Nude Mice 57
Different Growth Behavior of Xenografted Human Tumors on the Body Sides of Thymus-Aplastic Mice 61
Human Tumor Xenografts as a Model for Studying the Formation and Appearance of the Basement Membrane in Human Carcinomas 68
Interactions of Human Prostate Cancer Xenografts with Murine Stromal Cells 75
Differences in Growth Behavior of a Primary Renal Cell Carcinoma and Its Lymph Node Metastasis 80
Development of Human Malignant Tumors in Nude Mice Poorly Supplied with Magnesium 85
Secretion Behavior of the Cytokeratin Marker Cyfra 21-1: Studies in Xenografts of Human Lung and Pancreatic Carcinomas Established in Nude Mice 90
Biodistribution and Biokinetics of the Tc-99m Labeled Murine Monoclonal Anti-EGF Receptor Antibody Mab 425 in Nude Mice 96
Evaluation of Epidermal Growth Factor Receptors on Human Tumor Xenografts by MAb 425 and Its Fragments 101
Gene Expression of Differentiation Markers in the Nude Rats Xenotransplanted Human Thyroid Tumors 105
New Anticancer Drug Development Interim Results of the Cooperative Programme between the Freiburg Preclinical Anticancer Drug Development Group and the EORTC New Drug Development Office 108
Direct Cytotoxic Effects of Preparations Used as Unconventional Methods in Cancer Therapy in Human Tumor Xenografts in the Clonogenic Assay and in Nude Mice 115
Preclinical Activity of Alkylphosphocholines in vitro and against Human Breast Cancer Xenografts 123
Establishment and Characterization of Human Xenotransplanted Breast Carcinoma Lines: Use for the Screening of Alkylphosphocholines (APC) 129
Influence of Estradiol and Tamoxifen on the Growth and Regulation of c-erbB-2, Estradiol and Progesterone Receptors of Mammary Carcinoma 3366 Transplanted into Nude Mice 134
Effects of Liposomes with Defined Fatty Acid Composition on Xenotransplanted Human Mammary Carcinomas 138
Effect of Ascorbic Acid on Growth of Human Breast Cancers, Xenotransplanted into Athymic Nude Mice 142
Chemosensitivity of Malignant Melanoma Models: Longterm Complete Remission alter Regional Hyaluronidase/Vinblastine Therapy 145
Tumor Investigation: Control of their Metabolism after, Treatment by Pind Orf and Cisplatin 151
Local Control as an Endpoint in Experimental Radiation Therapy of Human Tumor Xenografts 154
Astatine 211: Endogenous-Radiotherapy for Thyroid Cancer 161
Influence of Tetrachlorodecaoxide on the Hypoxic Fraction of WiDr-Tumors in Nude Mice 166
Peripheral Blood Stem Cell-Initiated Human Hematopoiesis in Severe Combined Immunodeficient (SCID) Mice Is Accelerated by a Rat Fibroblast Cell Line Retrovirally Transfected with the Human IL-3 Gene 171
Transfer and Analysis of Bovine Immune Cells in SCID-Mice 176
The SCID-Mouse as a Model for Effective Immunotherapy of Hodgkin's Lymphoma 182
Xenotransplantation of a Novel Hodgkin Cell Line HD-MyZ into SCID-Mice 187
A Disseminated Human Neuroblastoma Model in SCID Mice 193
The Organoid Culture Assay (OCA) as an Alternative Method for Growing and Testing Individual Human Carcinomas 198
A Multilayered Postconfluent Tumor Cell Culture System for in vitro Drug Screening 204
Perspectives of the Use of Tissue Culture Methods as an Alternative to Human Prostate Cancer Xenografts in Nude Mice 209
Alternative Culture Systems for Mouse Embryonic Stem Cells 214
Author Index 219
Subject Index 221
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