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The book contains predominantly color illustrations, with some black-and-white illustrations.
As in the first three editions, we remain committed to the motto "less is more." Therefore, our objective in creating this edition has been to present what we consider to be the most pertinent material in a concise, palatable, and easily digestible fashion to the introductory student of immunology. Additional supportive material for students and course instructors can also now be found on a Web site (see below).
We are deeply indebted to Dr. Susan Gottesman, who contributed the chapter entitled, "Immunodeficiency and Other Disorders of the Immune System." We also thank Dr. Karen Yamaga, who updated the autoimmunity chapter. The important contributions of Dr. Patricia Giclas, who updated the complement chapter, and Dr. Arturo Casedeval, who added the new final chapter on resistance and immunization to infectious diseases, are also gratefully acknowledged.
Richard Coico would like to acknowledge the loving support of his family during the writing of this book. Their fortitude, inspiration, and enduring patience helped make the job an enjoyable adventure. Special thanks is extended to the following list of colleagues who generously provided their insightful scientific expertise and many helpful suggestions for the Fourth Edition: Drs. Ethan Shevach (NIH), David Margulies (NIH), Lloyd Mayer (Mount Sinai School of Medicine), Lakshmi Tamma (CUNY Medical School), Linda Spatz (CUNY Medical School), Laurel Eckhardt (Hunter College), Kathleen Barnes (Johns Hopkins School of Medicine), Soldano Ferrone (Roswell Park Memorial Institute), and Harriet Robinson (Emory University). Finally, he would like to thank his mentors, Drs. Ronald Curley, Susan Krown, Robert A. Good, and G. Jeanette Thorbecke, each of whom has greatly influenced his commitment and passion to the road taken.
Geoffrey Sunshine would like to thank Peter Brodeur (Tufts University Medical School) and Cindy Theodos (Tufts University Veterinary School) for their unstinting help during the preparation of his section of the current edition; they reviewed chapters in both the Third and Fourth Editions, and offered suggestions for making the material relevant and accessible to introductory readers. He is also grateful to the many friends and colleagues who answered questions about their areas of expertise, especially Mark Exley, Susan Kalled, and Paula Hochman. In addition, he would like to thank his family for their continued support and understanding during the writing.
The authors wish to express their appreciation to the staff members of John Wiley and Sons, Inc., who helped to bring the Fourth Edition to publication and did so with skill, patience, and good humor. Special thanks to our co-workers, including secretaries, office assistants, and other staff members, who helped with the preparation of the manuscript.
Finally, we wish to acknowledge the important contributions made by Dr. Sidney Leskowitz to the earlier editions of this book. The Hypersensitivity chapters are dedicated to his memory.
|Preface and Acknowledgments to the Third Edition|
|Preface to the Second Edition|
|Preface to the First edition|
|Acknowledgments to the First and Second Editions|
|Ch. 1||Introduction and Overview|
|Ch. 2||Elements of Innate and Acquired Immunity|
|Ch. 3||Immunogens and Antigens|
|Ch. 4||Antibody Structure|
|Ch. 5||Biological Properties of Immunoglobulins|
|Ch. 6||The Genetic Basis of Antibody Structure|
|Ch. 7||Antigen-Antibody Interactions|
|Ch. 8||Biology of the B Lymphocyte|
|Ch. 9||Biology of the T Lymphocyte|
|Ch. 10||The Role of the Major Histocompatibility Complex in the Immune Response|
|Ch. 11||Activation of T and B Cells by Antigen|
|Ch. 12||Control Mechanisms in the Immune Response|
|Ch. 14||Hypersensitivity Reactions: Antibody-Mediated, Type I - Anaphylactic Reactions|
|Ch. 15||Hypersensitivity Reactions: Antibody-Mediated, Type II - Cytotoxic Reactions and Type III - Immune Complex Reactions|
|Ch. 16||Hypersensitivity Reactions: T-Cell-Mediated, Type IV - Delayed-Type Hypersensitivity|
|Ch. 18||Immunodeficiency and Other Disorders of the Immune Response|
|Ch. 19||Transfusion Immunology|
|Ch. 20||Transplantation Immunology|
|Ch. 21||Tumor Immunology|
|Ch. 22||Immunoprophylaxis and Immunotherapy|
|Appendix: Partial List of CD Molecules|