Immunology / Edition 2

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Overview

Professor Klein has revised his acclaimed textbook of immunology as a result of feedback from his readership. The first edition received widespread praise for its clarity of explanation and won the Glaxo Prize for Textbook Writing. In his second edition, Professor Klein is joined by Dr Vaclav Horesji, who brings strength and expertise to the sections on cellular immunology.

As is expected, this book has been completely revised to reflect the enormous advances that have been made in our understanding of immunology in recent years. This edition contains the latest thinking on the role of natural killer cells, T-cell receptor signalling and accessory molecules, complement receptors, lymphokines and their receptors, toxic shock and LPs, and tumour immunology, to name but a few. As with the first edition, the authors have aimed to present only what is known and have kept the discussion of fashionable hypotheses to an absolute minimum. Finally, by including background material on methodology and basic biochemistry, the authors ensured that this book can be comprehended without referral to any other book.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

From The Critics
Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: This is the second edition of a textbook of basic immunology. The first edition was published in 1990. This edition was published in 1997 and reprinted in 1999. It is not clear whether any changes have been made in this new printing, but the information appears to be up to date.
Purpose: The purpose is to provide information on the organization and function of the human immune system. The book is divided so that in the first part organs and tissues are covered, then discussion progresses to cells and then molecules. In the second part the cell types involved in immune responses and the specific normal and abnormal immune responses are discussed. This approach is perhaps slightly different from other texts although nothing appears to be lacking.
Audience: The authors do not target a particular audience. The book would be suitable as a reference for someone familiar with the subject who might need some specific information as well as graduate students and fellows who are taking courses. It may elicit a mixed response from medical and dental students who may find more basic information and less immunopathology than they would like. The authors are authorities in their subject and the book reflects their expertise.
Features: The book represents a complete survey of immunology. It even includes a few words on the neuroendocrine system and its relationship to the immune system, which is still lacking in many texts. Although each reader is likely to find areas that are particularly well done, the sections on the development of stem cells, antigens, adhesion molecules, and details of he MHC deserve mention. All references are reviews rather than the primary literature. The artwork is limited in color but well done. Although immunopathologic issues are discussed, they receive less attention than the more descriptive aspects of the normal immune system.
Assessment: This is an excellent textbook for graduate students and fellows as well as a good reference for those who are more familiar with immunology. There is a wealth of information on basic immune mechanisms. The narrative is generally easy to read. It is well illustrated although the variety of colors used is limited. Given the changes in immunology since the first edition was published, a new edition is appropriate.
Pamela L. Witte
This is the second edition of an immunology text that is organized in roughly two parts. The first part deals with the cells, organ structure, and chemistry of the molecules of the immune system; and the second part focuses on immune response processes and alterations that cause clinical manifestations. The authors have focused on delivering a simple and direct discourse of the cells and molecules involved in immune and host defense responses. To achieve a readable text, he has presented ""facts"" only, and has foregone discussion of controversial topics of the day. This approach yields a text suitable for medical school classes, for whom the book is primarily targeted. However, the book is thorough enough to be useful to students with a deeper interest in immunology. The book features many updated or enhanced illustrations. Some are particularly excellent as teaching tools. There are many excellent summary tables, and the information appears quite complete. This is one of the classics in immunology texts. It presents immunology in a simple, straightforward manner. The authors are adept at focusing on the essential facts for understanding the immune system. The text is extremely readable. There are two deficiencies: first, the references are not completely current, few are past 1995; and second, the red and gray tones of the figures grow tiresome.
Marion C. Cohen
This is the second edition of a textbook of basic immunology. The first edition was published in 1990. This edition was published in 1997 and reprinted in 1999. It is not clear whether any changes have been made in this new printing, but the information appears to be up to date. The purpose is to provide information on the organization and function of the human immune system. The book is divided so that in the first part organs and tissues are covered, then discussion progresses to cells and then molecules. In the second part the cell types involved in immune responses and the specific normal and abnormal immune responses are discussed. This approach is perhaps slightly different from other texts although nothing appears to be lacking. The authors do not target a particular audience. The book would be suitable as a reference for someone familiar with the subject who might need some specific information as well as graduate students and fellows who are taking courses. It may elicit a mixed response from medical and dental students who may find more basic information and less immunopathology than they would like. The authors are authorities in their subject and the book reflects their expertise. The book represents a complete survey of immunology. It even includes a few words on the neuroendocrine system and its relationship to the immune system, which is still lacking in many texts. Although each reader is likely to find areas that are particularly well done, the sections on the development of stem cells, antigens, adhesion molecules, and details of he MHC deserve mention. All references are reviews rather than the primary literature. The artwork is limited in color but welldone. Although immunopathologic issues are discussed, they receive less attention than the more descriptive aspects of the normal immune system. This is an excellent textbook for graduate students and fellows as well as a good reference for those who are more familiar with immunology. There is a wealth of information on basic immune mechanisms. The narrative is generally easy to read. It is well illustrated although the variety of colors used is limited. Given the changes in immunology since the first edition was published, a new edition is appropriate.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780632054688
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/28/1997
  • Edition description: REV
  • Edition number: 2
  • Pages: 736
  • Product dimensions: 8.58 (w) x 10.86 (h) x 1.17 (d)

Table of Contents

Preface
1 Basic terms and concepts 1
2 Immune responses of invertebrates 9
3 Tissues and organs of the immune system 17
4 Blood cells in vertebrate immunity 41
5 Lymphocytes 58
6 Major histocompatibility complex molecules and their relatives 87
7 The T-cell and natural killer cell receptors 160
8 B-cell receptors, immunoglobulins and Fc receptors 204
9 Cell adhesion molecules 271
10 Cytokines and their receptors 291
11 Mediators and messengers 328
12 Complement and complement receptors 348
13 Antigens, superantigens and other lymphocyte-activating substances 393
14 Measurement of antigen-antibody interactions 422
15 Defence reactions mediated by phagocytes 442
16 T-lymphocyte and natural killer cell responses 465
17 B-lymphocyte responses 483
18 Systemic and regional immune responses 500
19 Immune response regulation 515
20 Immunological tolerance 522
21 Defence against invaders 532
22 Defence against tumours 596
23 Allergies and other hypersensitivities 608
24 Allograft reaction 635
25 Autoimmunity and autoimmune diseases 651
26 Immunodeficiency diseases 659
27 Immunoprophylaxis 669
App. 1 Amino acids and their symbols 675
App. 2 CD molecules 677
Index 687
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