Immunology of Gene Therapy / Edition 1

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  • Summarises and reviews the important field of genetic therapy with respect to the latest immunological advances in the lab and clinic
  • Unique treatment of immunology and immunotherapy in gene - approached from a vector and target organ point of view rather than from the perspective a specific diseases
  • Broad appeal - applicable for  immunology and genetics / gene therapy, recombinant DNA studies, transplantation, virology, cancer research and tumor research
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Editorial Reviews

Doody's Review Service
Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: This overview of immune responses to gene therapy focuses on the immune response to vectors as well as barriers that might interfere with gene targeting rather than on specific diseases, although obviously they are discussed.
Purpose: The intent is to describe the complex interactions between gene transfer and the immune system. In order to successfully use viral vectors to deliver functional genes, it is necessary to develop work-arounds to avoid antibody and cytotoxic responses, as these will otherwise negate therapy. The book presents what is currently known about the host immune response to gene transfer, and the editor suggests that this information will be particularly useful to students entering the field of gene therapy. This represents a different approach to providing information about this subject.
Audience: The book describes how the various parts of the immune system respond to attempts at gene therapy. Students would certainly find it helpful in their course work; in fact, an entire course could be built around this book. It summarizes a lot of data that might be needed by residents or physicians who do not treat patients using gene therapy. Physicians and scientists who are working directly in the area may already be aware of much of what is presented here, but even so, they may find it a worthwhile resource. The editor and the chapter authors are all experts in the areas they discuss.
Features: Each chapter approaches gene transfer with a careful consideration of the characteristics of the vector, its delivery, and the target organ(s), rather than specific diseases. Both local and systemic responses are discussed. The overview chapter is helpful in developing the context. There are a limited number of black-and-white illustrations, but this does not significantly detract from the presentation.
Assessment: This book, put together by experts, delivers a fresh approach to thinking about gene therapy and delivery of the vectors. The information is as current as a multiauthored book can be and would be useful to students as well as physicians.
From the Publisher
"This book provides a thorough and comprehensive description of the problems faced by gene therapists, and their continuing need to overcome the immune system to allow effective gene therapy in future clinical trials. It is well placed to be a useful and informative textbook, which I would highly recommend." (Immunology News, May 2009)

“This book, put together by experts, delivers a fresh approach to thinking about gene therapy and delivery of the vectors. The information is as current as a multiauthored book can be and would be useful to students as well as physicians.” (Doody's Reviews, March 2009)

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Product Details

  • ISBN-13: 9780470134061
  • Publisher: Wiley
  • Publication date: 12/3/2008
  • Edition number: 1
  • Pages: 398
  • Product dimensions: 6.00 (w) x 9.30 (h) x 1.00 (d)

Table of Contents

1. The immunology of gene transfer: an overview (David Lillicrap).

2. Innate immune responses to nucleic acids (Ishii and Akira).

3. The anti-viral Innate immune response (Daniel Muruve).

U. Calgary, Canada.

4. Immune responses to adenoviral vectors (Dmitry M. Shayakhmetov).

5. Immune responses to lentiviral vectors (Lung-Ji Chang).

6. Immune responses to adeno-associated virus vectors (Hildegund Ertl).

7. Immunology after in utero and neonatal gene transfer (Simon Waddington).

8. Immunology of hepatic gene transfer (Roland Herzog).

9. Immune responses to adenoviral, AAV, and lentiviral vector used for gene therapy of brain diseases (Pedro Lowenstein).

10. Immunology of cutaneous gene transfer (Soosan Ghazizadeh).

11. Immune responses to pulmonary gene therapy (Terence Flotte).

12. Induction of immune tolerance through gene transfer to hematopoietic stem cells (John Iacomini).

13. Reconstitution of the immune system by gene therapy (Adrian Thasher).

14. Genetics of the Immune Response to Proteins Expressed After Gene Transfer (Jay Lozier).

15. Immune modulation and transient suppression strategies (Valder Arruda).

16. Gene therapy for autoimmune diseases (Nicholas Giannoukakis).

17. Engineering of viral capsids to evade the host immune system (.

Hildegard Büning).

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