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More About This Textbook
Overview
Leading experts provide the only comprehensive book examining all aspects of immune response and immune-based treatments for HIV infection. Contributions, divided into three sections, discuss basic mechanisms, immunopathogenesis of HIV infection, and immune-based therapies. Researchers thoroughly review vaccine-including prospects of T cell vaccine-and gene therapy for HIV infection. Additional topics include organization of HIV genes, the role of co-receptors in signaling of lymphocytes, and biological response modifiers. This reference is designed for basic and clinical researchers, internists, pediatricians, infectious disease specialists, neuropathologists, oncologists, and rheumatologists.
The book contains black-and-white illustrations.
Editorial Reviews
Booknews
Contributions are organized to progress from fundamental aspects of immunity to HIV to a detailed consideration of the mechanisms underlying the immunopathogenesis of the disease. The conclusion considers approaches for vaccine design and for the treatment of established infection with agents whose principal targets are the restoration of immune function. The 30 chapters collect information which has hitherto been scattered in journals. Annotation c. by Book News, Inc., Portland, Or.From the Publisher
'Technical and well documented....a must book for AIDS researchers...highly recommended for all medical libraries.'AIDS Book Review Journal
'Contains a wealth of information for beginners and experts in the immunology of AIDS...The book challenges its readers to search the evidence for important clues and new leads.'
The New England Journal of Medicine.
'An excellent companion for grant-writung, lecture preparation or fact checking.'
Molecular Medicine Today
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Table of Contents
Basic Mechanisms: Genetic Organization of HIV; L. Ratner. T Cell Epitopes in the HIV1 Envelope Glycoprotein; R.F. Siliciano. B Cell in the HIV Glycoproteins; E. Björling, E. Norrby. Lymphocyte Adhesion Coreceptors and Their Roles in HIV1 Replication; J.A. Ledbetter. Immunopathogenesis: HIV and Lymph Node and Thymus; D.D. Patel, et al. Effects of HIV1 and HIV1 Glycoproteins on Signalling Pathways in Human T Lymphocytes; S. Gupta. Lymphocyte Apoptosis in HIV Infection; N. Oyaizu, S. Pahwa. Biological Activities of HIVspecific Peptides; S. Schwartz, et al. Phenotypic Analysis of Lymphocytes and T Cell Functions in HIV Infection; J. Giorgi, J. Nicholson. Cytotoxic T Lymphocyte Responses to HIV: From Seroconversion to AIDS; B. Autran. Type 1 and Type 2 Responses in HIV Infection and Exposure; G. Shearer, M. Clerici. Humoral Immunity to HIV1: Lethal Force or Trojan Horse? P.L. Nara. Autoimmunity in HIV; C. Via, A.R. Sarwari. Cytokine Cascade in HIV Infection; G. Poli, A.S. Fauci. Macrophage Functions in HIV Infection; S. Wahlet, et al. Dendritic Cell Functions in HIV Infection; S.C. Knight.Natural Killer Cells in HIV Infection; B. Bonavida, A. Jewett. HIV and Complement; M.P. Dierich, et al. Polymorphonuclear Leukocyte Function in HIV; S. Shyur, H. Hill. Mucosal Immunity in HIV Infection; H.F. Staats, J.R. McGhee. The Putative Role of HIV1 Envelope Proteins in the Neuroimmunology and Neuropathologyof CNS AIDS; P. Koka, J.E. Merrill. Immunopathogenesis of Kaposi's Sarcoma; R. Gallo, F. Samaniego. Pathogenesis of HIV associated Lymphoma; V.L. Ng, M.S. McGrath. Immunebased Therapy: The Immunotherapy of HIV Infection with Drugs; J. Hadden. Biologic Response Modifiers (Including Interleukins and Interferons); G.A. Fyfe, H.C. Lane. Thymic Hormones in the Treatment of AIDS and Other Infectious Disease; A.L. Goldstein, P.S. Sarin. Growth Factors in the Treatment of Disease; D.T. Scadden, D. Golde. TCell Vaccination for HIVseropositive Patients; H. Atlan, I.R. Cohen. HIV Vaccines; D.P. Bolognesi. Gene Therapy; R.A. Morgan. Index.