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Immunology of the Nervous System

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Neuroimmunology has come of age since 1980, shaped by advances in its parent disciplines of neuroscience and immunology. The evolution of the field made it clear that the general principles of immunology must be applied in a highly specialized fashion when dealing with immunological reactions in the nervous system. This book provides a comprehensive review of the subject, beginning with a unique historical survey including disease-related observations, which is then followed by an overview of immunological ...

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1997 Hard cover ABSOLUTELY BRAND NEW(shrinkwrapped-NEW)! ! -No expedite, No international shipping available Sewn binding. Cloth over boards. 848 p. Audience: General/trade.

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Overview

Neuroimmunology has come of age since 1980, shaped by advances in its parent disciplines of neuroscience and immunology. The evolution of the field made it clear that the general principles of immunology must be applied in a highly specialized fashion when dealing with immunological reactions in the nervous system. This book provides a comprehensive review of the subject, beginning with a unique historical survey including disease-related observations, which is then followed by an overview of immunological principles and functions. Cellular responses during neuroimmunological events, with emphasis on microglia, macrophages, astrocytes, and lymphocytes, are detailed. The largest section of the book deals with the cellular and humoral roles of the nervous and immune systems in basic physiological and disease processes such as antigen presentation, cytokines expression, viral infection and immunosuppression. The final section on neuroimmunology of disease covers autoimmune disorders, AIDS, cancer, and the immunological diseases of the peripheral nervous system.
For neuroscientists, immunologists, and neurologists, this will be a valuable resource. It may be used both as a text in neuroimmunology courses or as a reference by basic scientists and clinicians.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Alexander Kolchinsky, PhD (University of Illinois at Chicago College of Medicine)
Description: This is a comprehensive, fundamental review of immunology of the nervous system. Written by a group of leading scholars, it is thoughtfully compiled, carefully edited, and conveniently structured. The book consists of 22 chapters divided into five sections: a brief history of neuroimmunology; basic concepts; immunologically active cells in the nervous system; cellular and humoral responses in the nervous system reviewed at all levels; and neuroimmunology of selected diseases, with individual chapters on demyelinating diseases, AIDS, and tumors of the CNS. Two chapters deal with immunology of the eye, a topic that usually stands apart from both disciplines. Among other subjects, practical issues of cell transplantation and viral infections in the CNS are addressed. Expression of cytokine molecules is presented in great detail.
Purpose: The purpose of the book is stated in its eloquent preface. It is intended to give a comprehensive description of differences, similarities, functional overlapping, and interactions of the immune and nervous systems. In particular, this up-to-date book challenges some widespread concepts, first of all the exclusive immuno-privileged status of the CNS.
Audience: As stated in the preface, this book is not just for specialists, but also for students, postdoctoral fellows, and residents at all levels, and will remain the reference for years to come.
Features: The book has an extensive and useful list of abbreviations and a convenient index. It is rather sparingly illustrated with black-and white-schemes, drawings, and microphotographs. Many concepts are presented as concise tables.
Assessment: The book summarizes the achievements of a relatively new field born at the crossroads of two disciplines. Its value for anyone in fields related to immunology or neuroscience cannot be overestimated.
Alexander Kolchinsky
This is a comprehensive, fundamental review of immunology of the nervous system. Written by a group of leading scholars, it is thoughtfully compiled, carefully edited, and conveniently structured. The book consists of 22 chapters divided into five sections: a brief history of neuroimmunology; basic concepts; immunologically active cells in the nervous system; cellular and humoral responses in the nervous system reviewed at all levels; and neuroimmunology of selected diseases, with individual chapters on demyelinating diseases, AIDS, and tumors of the CNS. Two chapters deal with immunology of the eye, a topic that usually stands apart from both disciplines. Among other subjects, practical issues of cell transplantation and viral infections in the CNS are addressed. Expression of cytokine molecules is presented in great detail. "The purpose of the book is stated in its eloquent preface. It is intended to give a comprehensive description of differences, similarities, functional overlapping, and interactions of the immune and nervous systems. In particular, this up-to-date book challenges some widespread concepts, first of all the exclusive immuno-privileged status of the CNS. "As stated in the preface, this book is not just for specialists, but also for students, postdoctoral fellows, and residents at all levels, and will remain the reference for years to come. "The book has an extensive and useful list of abbreviations and a convenient index. It is rather sparingly illustrated with black-and white-schemes, drawings, and microphotographs. Many concepts are presented as concise tables. "The book summarizes the achievements of a relatively new field born at the crossroads oftwo disciplines. Its value for anyone in fields related to immunology or neuroscience cannot be overestimated.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780195078176
  • Publisher: Oxford University Press, USA
  • Publication date: 5/28/1997
  • Edition number: 1
  • Pages: 848
  • Product dimensions: 6.69 (w) x 9.50 (h) x 1.89 (d)

Table of Contents

I. History of Neuroimmunology Byron Waxman, Foundation for Microbiology

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