Immunosurveillance, Immunodeficiencies and Lymphoproliferations: Lymphoproliferative Disorders in Congenital and Acquired Immunodeficiencies / Edition 1by S.H. Oertel
Pub. Date: 12/06/2001
Publisher: Springer Berlin Heidelberg
This book covers lymphoproliferative disorders in patients with congenital or acquired immunodeficiencies. Acquired immunodeficiencies are caused by infections with the human immunodeficiency virus or arise following immunosuppressive therapy administered after organ transplantation or to treat connective tissue diseases such as rheumatoid arthritis. It was recently discovered that various diseases or therapeutic modalities that induce a state of immunosuppression may cause virally driven lymphoproliferations. This book summarizes for the first time this group of immunodeficiency-associated lymphoproliferations.
Table of ContentsFrom the contents: Immunosurveillance, immunodeficiency and lymphoproliferations.- Clinicopathological characteristics of post-transplant lymphoproliferative disorders (PT-LPD).- Iatrogenic lymphoproliferative disorders in non-transplantation settings.- The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative disorders.- Dendritic cells for the induction of Epstein-Barr virus (EBV) immunity.- NF-kB inhibition in EBV-transformed lymphoblastoid cell lines.- EBV viral load in patients as a tool to diagnose and monitor PT-LPD.- The role of immunosuppression in lymphoma.- Identification of prognostic factors in PT-LPD.- Methods and objectives of a large US multi-center case-control study of PT-LPD in renal transplant patients.- Antiviral treatment of EBV-associated lymphoproliferations.- Low-dose chemotherapy for children with PT-LPD.- Engineered antibody for treating lymphoma.- Treatment of post-transplant lymphomas with anti-B-cell monoclonal antibodies.
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