Immunotoxicology and Risk Assessment / Edition 1

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This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology foc us on hazard identification, appropriate assays, dose response, and ri sk assesment by mathematical models and safety factors. It will be a u seful reference to toxicologists because it will incorporate new guide lines that the EPA is bringing out later this year for all chemicals r egulated under the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. Regulatory sections in each cha pter focus on data from both the US Food and Drug Administration, as w ell as data applicable to western European Nations.

Reviews basic tenents & mechanisms at the cellular & molec- ular levels; xenobiology; hazard identification methodology.

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Product Details

  • ISBN-13: 9780306459719
  • Publisher: Springer US
  • Publication date: 5/31/1999
  • Edition description: 1999
  • Edition number: 1
  • Pages: 382
  • Product dimensions: 9.00 (w) x 6.00 (h) x 1.00 (d)

Table of Contents

1 Introduction to Immunotoxicology 1
2 Innate Immunity 7
3 Cells of the Immune System 15
4 Immunogenicity and Antigenicity 39
5 Antigen-Presenting Cells 50
6 Antigen Presentation 57
7 Surface Interactions and Intracellular Signaling 71
8 B-Cell Activation 89
9 Antibodies 99
10 Immunological Memory 117
11 Complement 123
12 Phagocytosis and Intracellular Killing 139
13 Immediate Hypersensitivity Reactions 155
14 Autoimmunity 173
15 Delayed Hypersensitivity Reactions 187
16 Killer Cells 197
17 Killer Cells and Viral Infections 211
18 Transplantation 219
19 The Kines 229
20 Assessment of Biological Significance: Host Defense and Tumor Models 247
21 Risk Characterization 271
22 References 283
Index 371
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