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This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on hazard identification, appropriate assays, dose response, and risk assesment by mathematical models and safety factors. It will be a useful reference to toxicologists because it will incorporate new guidelines that the EPA is bringing out later this year for all chemicals regulated under the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. Regulatory sections in each chapter focus on data from both the US Food and Drug Administration, as well as data applicable to western European Nations.
Reviews basic tenents & mechanisms at the cellular & molec- ular levels; xenobiology; hazard identification methodology.
|1||Introduction to Immunotoxicology||1|
|3||Cells of the Immune System||15|
|4||Immunogenicity and Antigenicity||39|
|7||Surface Interactions and Intracellular Signaling||71|
|12||Phagocytosis and Intracellular Killing||139|
|13||Immediate Hypersensitivity Reactions||155|
|15||Delayed Hypersensitivity Reactions||187|
|17||Killer Cells and Viral Infections||211|
|20||Assessment of Biological Significance: Host Defense and Tumor Models||247|