The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies / Edition 1

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Overview

This book provides a detailed overview of the fundamentals of tumor biology and the influence of biologic factors on the design of therapeutic strategies and the outcome of established and emerging treatments. Particular attention is devoted to multidisciplinary combined modality therapy. The topics reviewed include tumorigenesis, cell proliferation, angiogenesis, physiology of malignant tissues, adhesion and invasion, development of metastases, and the role of the immune system. Subsequent chapters discuss the principles of chemotherapy, radiotherapy, and molecularly targeted therapy, explain treatment resistance, and provide strategies for rational combinations, including the design of translational studies. Furthermore, the principles and clinical implications of diverse new diagnostic and therapeutic approaches are presented. The chapters in this book have been written by an outstanding group of basic scientists, clinical researchers, and cancer professionals with long experience in the field.

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Editorial Reviews

From the Publisher
From the reviews:

“The stated aim of the editors of this book is ‘to provide the practising radiation oncologist with a concise overview of the most important and up-to-date information pertaining to tumour biology as it impacts on cancer treatment’ … useful guide to the molecular era of cancer biology and personalised cancer therapy, particularly in relation to radiation oncology. … The book would be of interest to any oncologist and would serve as a useful revision tool for the FRCR part 1 examination.” (Joe O’Sullivan, RAD Magazine, December, 2009)

Aus den Rezensionen:

“Dieses umfassende Lehrbuch erläutert alle wesentlichen Gesichtspunkte der Tumorbiologie ... Die Literaturhinweise sind umfangreich, vollständig und aktuell, sofern dies in einem Lehrbuch überhaupt möglich ist. Die Autoren sind international ausgewiesene Grundlagenwissenschaftler und klinische Krebsforscher. Die Kapitel weisen ein qualitativ hochwertiges Layout mit zahlreichen, durchgehend farbigen Bildern auf und sind gut lesbar. Das Buch stellt eine wesentliche Bereicherung der tumorbiologischen Literatur dar. Wir empfehlen es als aktuelles radiobiologisches Standardwerk.“ (Stephan Roth, in: Strahlentherapie und Onkologie, 1/December/2009, S. 844)

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Product Details

  • ISBN-13: 9783540743859
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 5/28/2009
  • Series: Medical Radiology / Radiation Oncology Series
  • Edition description: 2009
  • Edition number: 1
  • Pages: 370
  • Product dimensions: 7.70 (w) x 10.80 (h) x 0.90 (d)

Meet the Author

M. Molls, Professor, Chairman of the Department of Radiation Oncology, Klinikum rechts der Isar der TU Muenchen, Germany

C. Nieder, Professor at the University of Tromsø, Norway, Oncologist

M Anscher, Professor and Chairman, Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA

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Table of Contents

Tumorigenesis.- Tumor Growth and Cell Proliferation.- Angiogenesis.- Tumor Physiology (Phenomenology).- Adhesion, Invasion, Integrins and Beyond.- Development of Metastases.- Role of the Immune System in Cancer Development and Therapeutic Implications.- Cancer Prevention .- Tumor Detection by Morphological and Biological Imaging.- Tumor Detection by Biological Markers (Serum, Urine, Breathing Gas, Proteomics).- Quantitative Cell Kill by Chemo- and Radiotherapy.- Impact of Molecularly Targeted Agents on Cell Kill in Bi- or Trimodal Approaches (i.e. plus Chemo, Radio-, or Radiochemotherapy).- Translational Studies for Target-Based Drugs.- Molecular Mechanisms of Treatment Resistance.- Physiological Mechanisms of Treatment Resistance.- Influence of Repopulation on Treatment Resistance.- Molecular Tools, Gene Expression Profiling.- Strategies of Gene Transfer/Silencing and Technical Considerations.- Tumor Biology’s Impact on Clinical Cure Rates.- Can Dose-Escalated Radiotherapy Eventually Cure All Biologically Distinct Subsets of a Certain Tumor Type? Answers from Stereotactic Lung and Liver Radiotherapy Experience.-Low-Dose Radiotherapy – A Chemopotentiator?.- Treatment of the Primary Tumor in Metastatic Cancer: Influence on Outcome.- Subject Index.- List of Contributors.

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