In Vitro Effects Of Actively Delivered Coencapsulated Curcumin And Cisplatin Nanoliposomes On Squamous Oral Carcinoma.

Overview

Squamous oral cell carcinoma is primarily treated with palliative surgery followed by concomitant chemotherapy or radiation. Chemotherapeutic agents have significant toxicity on the healthy tissues and their accessibility to tumors in free form is limited. Hence they are good candidates for incorporation into pharmaceutical carriers which improve their bioavailability and lessen their toxicity. Chemopreventive agents which are naturally occurring substances can also be incorporated into carriers for more ...
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Overview

Squamous oral cell carcinoma is primarily treated with palliative surgery followed by concomitant chemotherapy or radiation. Chemotherapeutic agents have significant toxicity on the healthy tissues and their accessibility to tumors in free form is limited. Hence they are good candidates for incorporation into pharmaceutical carriers which improve their bioavailability and lessen their toxicity. Chemopreventive agents which are naturally occurring substances can also be incorporated into carriers for more effective delivery and treatment benefits. Curcumin, the component of the spice turmeric well known for its anticancer and chemopreventive properties, was incorporated into liposomes using different preparation techniques and characterized for parameters such as drug loading efficiency, size, in vitro release and in vitro cytotoxicity on a squamous carcinoma cell line. Liposomes were prepared with different methods---thin layer evaporation, ethanol injection and extrusion methods respectively obtaining, multilamellar (MLVs), ethanol injection and small unilamellar vesicles (SUVs). The preparation techniques influenced the size, encapsulation efficiency, in vitro release and cytotoxicity profiles. Encapsulation efficiency increased with decrease in drug to lipid ratio in the following rank order - MLVs > SUVs > Ethanol injection vesicles. In vitro release profiles of the three different formulations demonstrated that leakage of curcumin depended on the type of vesicle and encapsulation efficiency. Based on these results, liposomal formulations should be tailored to specific applications that require controlled release of encapsulated pharmaceutical agents. Among other drugs for head and neck cancers, chemotherapy regimens include the use of platinum based compounds, which have proven to be very successful in clinical trials. However the development of resistance to these compounds midway through the therapy to date impairs the successful culmination of the therapy. Curcumin was incorporated into liposomes along with cisplatin, using different preparation techniques and characterized for parameters such as drug loading efficiency, size, in vitro release and in vitro cytotoxicity on a squamous carcinoma cell line. Liposomes were prepared with different methods---thin layer evaporation, reverse phase evaporation and extrusion methods resulting in compound multilamellar (MLVs), large unilamellar (LUVs) and small unilamellar vesicles (SUVs) respectively. The preparation techniques influenced the size, encapsulation efficiency, in vitro release and cytotoxicity profiles. In vitro release profiles of the three different formulations demonstrated that leakage of curcumin depended on the type of vesicle and encapsulation efficiency. The compound liposomes were tested on cisplatin resistant and sensitive SCC9 cells to investigate if they were effective in the inhibition and reversal of resistance development. Multidrug carriers were also formulated using a Dipalmitoyl Phosphatidylcholine (DPPC) as a primary lipid, with incorporation of a lysolipid to achieve controlled release of the drugs loaded within. Diagnostic ultrasound energy was then employed as a tool to achieve controlled release from the newly developed multidrug carriers at a frequency of 7.5 MHz and four different power intensities depending on the pulse repetition time. The optimal lipid composition and the intensity settings of ultrasound energy were chosen to formulate a new class of nanoliposomes---ultrasound sensitive nanoliposomes (USNL). The USNLs released increasing amounts of drug in response to increasing irradiation times while the drug release was not significant...
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Product Details

  • ISBN-13: 9781243555847
  • Publisher: BiblioLabsII
  • Publication date: 9/3/2011
  • Pages: 90
  • Product dimensions: 7.44 (w) x 9.69 (h) x 0.19 (d)

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