In Vitro Toxicology / Edition 2

In Vitro Toxicology / Edition 2

by Shayne C. Gad, Steven Strauss
     
 

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms.
Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for

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Overview

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms.
Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest 'in vitro' models has risen.
This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations.
Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.

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Product Details

ISBN-13:
9781560327691
Publisher:
Taylor & Francis
Publication date:
11/02/2000
Edition description:
REV
Pages:
422
Product dimensions:
6.20(w) x 9.10(h) x 1.10(d)
Age Range:
18 Years

Table of Contents

Contributors
Preface
1Introduction1
2General Principles for In Vitro12
3Ocular Toxicity Assessment In Vitro Toxicology23
4In Vitro Methods to Predict Skin Irritation49
5Lethality Testing62
6In Vitro Genetic Toxicity Testing94
7Pyrogenicity and Muscle Irritation128
8In Vitro Models for Evaluating Developmental Toxicity139
9Neurotoxicology In Vitro188
10In Vitro Assessment of Nephrotoxicity222
11Primary Hepatocyte Culture as an In Vitro Toxicologic System for the Liver275
12Application of In Vitro Model Systems to Study Cardiovascular Toxicity305
13Gastrointestinal Toxicology: In Vitro Test Systems326
14In Vitro Immonotoxicology347
15Strategy and Tactics for Employment365
16Scientific and Regulatory Considerations in the Development of In Vitro Techniques in Toxicology380
17Safety Issues in the Use of Human Tissue by In Vitro Metabolism and Toxicology Laboratories388
Index397

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