In Vitro Toxicology / Edition 2 by Shayne C. Gad, Steven Strauss | | 9781560327691 | Hardcover | Barnes & Noble
In Vitro Toxicology / Edition 2

In Vitro Toxicology / Edition 2

by Shayne C. Gad, Steven Strauss
     
 

ISBN-10: 1560327693

ISBN-13: 9781560327691

Pub. Date: 11/02/2000

Publisher: Taylor & Francis

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms.
Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for

Overview

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms.
Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest 'in vitro' models has risen.
This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations.
Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.

Product Details

ISBN-13:
9781560327691
Publisher:
Taylor & Francis
Publication date:
11/02/2000
Edition description:
REV
Pages:
422
Product dimensions:
6.20(w) x 9.10(h) x 1.10(d)
Age Range:
18 Years

Table of Contents

1. Introduction, 2. General principles for in vitro toxicology, 3. Ocular toxicity assessment in vitro toxicology, 4. In vitro methods to predict dermal toxicology, 5. Lethality testing, 6. Mutagenicity/genotoxicity, 7. Pyrogenicity and muscle irritation, 8. In vitro assays for development toxicity, 9. Neurotoxicology in vitro, 10. In vitro assessment of nephrotoxicity, 11. Primary hepatocyte culture as an in vitro toxicological system for the liver, 12. Application of in vitro model systems to the study of cardiovascular toxicity, 13. Gastrointestinal toxicology: in vitro test systems, 14. In vitro assessment of immunotoxicity, 15. Strategy and tactics for employment, 16. Scientific and regulatory considerations in the development of in vitro techniques in toxicology, 17. Safety issues in the use of human tissues by in vitro toxicology laboratories.

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