In Vitro Toxicology / Edition 2

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Overview

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms.
Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest 'in vitro' models has risen.
This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations.
Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.

This book contains black-and-white illustrations.

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Editorial Reviews

From The Critics
Reviewer: David Chandler, PhD, DABT, CIA (3M)
Description: This book reviews the most recent findings on in vitro testing and the support for these tests.
Purpose: The objectives of this book are to review the in vitro models used in toxicology, evaluate each test's ability to predict results as compared to in vivo findings, regulate acceptance of the models, and provide specific evaluation of end points used in toxicology testing.
Audience: The audiences are experienced toxicologists with an interest in regulatory compliance and testing of materials. They would be interested in animal use reduction and acceptance by regulatory agencies.
Features: This book reviews the various end points used in toxicology and compares the findings from in vivo studies to in vitro models. Each chapter carefully reviews the findings and indicates which of the in vitro tests provide the most accurate assessment of the materials properties. Experts in the field provide an exceptional and thorough evaluation of the materials.
Assessment: This second edition is an excellent review of the current state of in vitro testing and is well written. The authors are known experts in the fields that they have reviewed. The chapters evaluate the in vitro tests and compare them to known in vivo tests, but the most valuable content is the comments on the strength of these tests for prediction as compared to the in vivo counterparts. The text will be very valuable to practicing toxicologists.
From The Critics
Reviewer: David Chandler, PhD, DABT, CIA (3M)
Description: This book reviews the most recent findings on in vitro testing and the support for these tests.
Purpose: The objectives of this book are to review the in vitro models used in toxicology, evaluate each test's ability to predict results as compared to in vivo findings, regulate acceptance of the models, and provide specific evaluation of end points used in toxicology testing.
Audience: The audiences are experienced toxicologists with an interest in regulatory compliance and testing of materials. They would be interested in animal use reduction and acceptance by regulatory agencies.
Features: This book reviews the various end points used in toxicology and compares the findings from in vivo studies to in vitro models. Each chapter carefully reviews the findings and indicates which of the in vitro tests provide the most accurate assessment of the materials properties. Experts in the field provide an exceptional and thorough evaluation of the materials.
Assessment: This second edition is an excellent review of the current state of in vitro testing and is well written. The authors are known experts in the fields that they have reviewed. The chapters evaluate the in vitro tests and compare them to known in vivo tests, but the most valuable content is the comments on the strength of these tests for prediction as compared to the in vivo counterparts. The text will be very valuable to practicing toxicologists.
Booknews
There now exist a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints irritation, sensitization, lethality, mutagenicity, and developmental toxicity and the full spectrum of target organ systems skin, eye, heart, liver, kidney, nervous system, etc.. This volume devotes chapters to each of these specialty areas from a perspective of presenting the principal models and their uses and limitations. Also included are chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods. Annotation c. Book News, Inc., Portland, OR booknews.com

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781560327691
  • Publisher: CRC Press
  • Publication date: 11/2/2000
  • Edition description: REV
  • Edition number: 2
  • Pages: 544
  • Product dimensions: 6.20 (w) x 9.10 (h) x 1.10 (d)

Table of Contents

Contributors
Preface
1 Introduction 1
2 General Principles for In Vitro 12
3 Ocular Toxicity Assessment In Vitro Toxicology 23
4 In Vitro Methods to Predict Skin Irritation 49
5 Lethality Testing 62
6 In Vitro Genetic Toxicity Testing 94
7 Pyrogenicity and Muscle Irritation 128
8 In Vitro Models for Evaluating Developmental Toxicity 139
9 Neurotoxicology In Vitro 188
10 In Vitro Assessment of Nephrotoxicity 222
11 Primary Hepatocyte Culture as an In Vitro Toxicologic System for the Liver 275
12 Application of In Vitro Model Systems to Study Cardiovascular Toxicity 305
13 Gastrointestinal Toxicology: In Vitro Test Systems 326
14 In Vitro Immonotoxicology 347
15 Strategy and Tactics for Employment 365
16 Scientific and Regulatory Considerations in the Development of In Vitro Techniques in Toxicology 380
17 Safety Issues in the Use of Human Tissue by In Vitro Metabolism and Toxicology Laboratories 388
Index 397
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