In Vivo Immunology: Histophysiology of the Lymphoid System / Edition 1

by Paul Nieuwenhuis

Overview

In 1966, the first Germinal Centre Conference was held in Bern, Switzerland, as a result of an initiative from C. C. Longdon of Oak Ridge, Tennessee and H. Cottier of Bern. Fifteen years later, in June of 1981, the 7th conference in this series was held in Groningen, the Netherlands. At this "International Conference on Lymphatic Tissues and Germinal Centers in Immune Reactions," instead of focusing on germinal centres only, the intricate relationships between various constituents of the lympho-myeloid complex consti­ tuted the theme of the meeting. As Yoffee stated in 1966, "Perhaps we should consider not only the germinal centre itself but the surrounding tissue as well. " Over the years, these conferences have brought together a small but dedicated group of scientists, sharing (1) a fundamental interest in the physiology of the lymphoid system proper, and (2) the recognition that, only in the in vivo situation can the final answers be obtained, however ingeniously in vitro experiments may mimic reality. In 1966, the conference lasted three days and included 57 contributions "which were discussed at length. " The present conference accomodated 62 free papers and 64 poster presentations as well as some 24 additional abstracts selected from more than 200 submissions. Prominent among the selection criteria was the adage "in vivo veritas. " This volume represents the presentations from the 1981 Germinal Centre Conference.

Product Details

ISBN-13:	9781468490688
Publisher:	Springer US
Publication date:	12/12/2012
Series:	Advances in Experimental Medicine and Biology , #149
Edition description:	Softcover reprint of the original 1st ed. 1982
Pages:	852
Product dimensions:	7.01(w) x 10.00(h) x 0.07(d)

Table of Contents

Session 1 Bone Marrow, B Cell Differentiation, and the B Cell System.- Chairman’s Introduction: Bone Marrow and B Cell Differentiation.- Migration of Erythropoietic and Prebursal Stem Cells from the Early Chicken Embryo to the Yolk Sac.- Antigens Associated with Bursal and Thymic Reticular Epithelial Cells.- The Development of B Lymphocytes and Their Reactivity in Pig Fetuses.- Regulation of B Cell Development in Mouse Bone Marrow.- Distribution and Functional Properties of PNA+ and PNA- Cells in Central and Peripheral Lymphoid Organs of the Chicken.- Peanut Agglutinin (PNA) Binding as a Marker for Immature Human B Lymphocytes. Is Bone Marrow Not the Complete Bursa-Equivalent?.- Functional Studies on Subpopulations of B-Lymphocytes and Bone Marrow Cells.- Human Sessile B Lymphocyte Marker Defined by a Monoclonal Antibody.- Marginal Zones: The Largest B Cell Compartment of the Rat Spleen.- The Proliferative Activity of Antibody Forming Cells in the Mouse Bone Marrow.- The Origin of Marginal-Zone Cells.- Functional Antigen Binding by the Defective B Cells of CBA/N Mice.- The Role of Bursal Microenvironment in the Maturation of B Cells.- Fluorescence Activated Cell Sorter Analysis of Murine B Cell Development.- Pre B Cell Leukaemia in the Rat.- Differences in In Vivo Functional Capacities of Avian Precursor B and T Cells Following In Vitro Incubation.- Lymphoid Antigens on Non-lymphoid Factor-Dependent Haemopoietic Cell Lines.- Session 2 Lymphocyte Migration.- Chairman’s Introduction: Experimental Approaches to Lymphocyte Traffic: Pitfalls of the Tracer Sample Method.- Two Populations of Murine LPS-Responsive B Lymphocytes Differing in Recirculatory Capacity.- A Method for Studying the Dynamics of the Primary Migration of Human Lymphocytes Using Indium-III Oxine Cell Labelling.- LYT Phenotype and Lectin Binding Properties of Mouse Lymphocytes Which Enter Lymph Nodes.- Unilateral Localization of Hapten-Specific B Memory Cells in Lymph Node Draining A Footpad Injection of Antigen.- Organ-Specific Homing of B Cell Hybridomas.- Isolation of Factors Causing Enhanced Lymphocyte Adherence to High Endothelial Venules In Vitro.- Lymphocyte-Endothelial Interactions and Hisompatibility Restriction.- Selective Migration of Murine Lymphocytes and Lymphoblast Populations and the Role of Endothelial Cell Recognition.- The Effect of Stimulated Macrophages on High Endothelial Venules and Germinal Centres in Lymph Nodes of Rat.- Homing Pattern of Newly Formed Splenic Lymphocytes.- The Efficiency of Entry of Lymphoid Cells into Lymphoid and Non-lymphoid Tissues.- Morphological Aspects of the Local Immune Response to Influenza in Rats.- Session 3 Thymus, T Cell Differentiation, and the T Cell System.- Chairman’s Introduction: Thymus, T Cell Differentiation and the T Cell System.- Detection of MHC, THY-1, LYT-1 and LYT-2 Antigens in the Developing Mouse Thymus.- Role of Thymic Medullary Lymphocytes in the Intra-Thymic Maturation Process.- Sequential Development of THY-1+ Subpopulations in Regenerating Thymus After Bone Marrow Transplantation.- “Thymic Nurse Cells” Contain the First Virus Producing Cells After Inoculation of the Radiation Leukemia Virus in C57BL/Ka Mice.- Studies on the Maturity of Cells Migrating From the Thymus to the Periphery in Mice.- Lymphocytes in Mice with Membrane Antigens Common to Human Thymocytes.- Cloned T Cell Progenitors From Mouse Bone Marrow Give Rise to Lymphocytes with Multiple Anti-H-2 Reactivities.- Frequency and Restriction of Cytotoxic T Lymphocyte Precursors in Neonatally Thymectomized Mice.- Accumulation of Mature T and B Cells and Abnormalities of Lymphocyte Traffic in the Thymus of Aged NZB × SJL F1 Female Mice.- Structural and Functional Alterations of the Aging Human Thymus.- Study of Beta Adrenoceptors on Subpopulations of Thymocytes Separated on Ficoll-Hypaque Density Gradients.- Lymphocyte Differentiation in the Rabbit Thymus.- Monoclonal Antibodies Against Rat T Cells.- Ontogeny of the Immune System in Fish — Role of the Thymus.- The Thymus-Hypophysis Interaction in the Developing Chick Embryo: Thymic Epithelial Cells in Hypophysectomized Embryos.- Monoclonal Antibodies to Cell Surface Antigens on Lymphoid and Non-lymphoid Cells of the Mouse.- Cultured Thymic Epithelium. Its Morphological Characterization and Biological Effect In Vivo in Athymic Nude Rats.- Ontogeny of LYT 1 and LYT 123 Lymphocytes in the Mouse Thymus.- Session 4 Non-Lymphoid Cells: Factors in Immune Reactions.- Chairman’s Introduction: Non-lymphoid Cells and Factors in Immune Reactions.- Evidence for Extrinsic Origin of Ia Positive Cells in Embryonic Murine Thymus.- Ia Positive Cells in the Medulla of Rat Thymus Are Bone Marrow Derived.- Morphological Assessment of Immunologically Relevant Cells in the Thymus.- The Principal Cells in the Thymus Expressing MHC Antigens Are Epithelial.- Interdigitating Cells. A Guiding Cell Line in T-Cell Reactivity.- The Immunological Significance of Birbeck Granule Containing Cells.- A Comparative Study of Accessory Cells Derived from the Peritoneum and from Solid Tissues.- Characterization of Bone Marrow Derived Macrophage as Ia-Bearing Accessory Cells.- The Frequency and Surface Markers of Antigen-Laden Cells in Thoracic Duct Lymph.- Rat Thymus Micro-Environment: An Ultrastructural and Functional Characterization.- The Effect of Veiled Cells on Lymphocyte Function.- Effect of an Acute Viral Infection by a Silent Virus on the Humoral Immune Responses.- Modulatory Effects of Splenic Accessory Cells on In Vivo Antibody Response.- Macrophages, Langerhans Cells, Interdigitating and Dendritic Accessory Cells: A Summary.- Session 5 Lymphoepithelial Relations: GALT/BALT.- Chairman’s Introduction: Gut and Bronchus Associated Lymphoid Tissue: An Overview.- Intestinal Mast Cells and Their Relation to Mesenteric Lymph Nodes.- Ultrastructural Analysis of Lymphoid Subpopulations and Their Relation to Stationary Cells in the Epithelial Crypts and the Follicles During Early Ontogeny of the Human Tonsilla Palatina.- Histology and Immunohishemistry of Bronchus Associated Lymphoid Tissue (BALT) in the Rat.- Preferential Uptake of Soluble Antigen by Respiratory Tract Epithelium Overlying Bronchus-Associated Lymphoid Tissue in the Rat.- Macrophage Function in Peyer’s Patch Epithelium.- Development of Immune Potential and Migration Pattern of Cells from Germfree (GF) and Conventionally (CONV) Reared Rats.- Unique Functional Characteristics of Mucosal Mast Cells.- Session 6 Basic Immunological Aspects of GVHR.- Chairman’s Introduction: H-2-Restriction of T Cells Mediating Lethal Graft-Versus-Host-Disease to Minor Hisompatibility Determinants.- Induction of Either Acute or Chronic Graft-Versus-Host-Disease Due to Genetic Differences Among Donor T Cells.- Subpopulations of T Cells in the Rat That Mediate Graft-Versus-Host Reactions and Lethal Graft-Versus-Host Disease.- Alterated Immunological Reactivity in Rats Sustaining a Graft-Versus-Host-Reaction (GvHR).- Specific Systemic Graft-Versus-Host Resistance: Failure to Induce in Adult F1 Rats Tolerized at Birth to Anti-MHC Receptors on Parental T Cells.- The Rowett Nude (rnu) Rat as a Host in the Popliteal Lymph Node GVH Reaction.- Specific Suppression of Anti-Host Immune Reactivity in Graft-Versus-Host Reaction.- Systemic Immunomodulation Induced by a “Loco-Regional” GVHR in the Rat.- Lymphoid Tissue Transplantation in Rats Leads to a GVHR, Inducing a Specific T-Cell Mediated Autoreactivity Against MHC-Antigens.- Session 7 Immune Response Regulation.- Immunoregulatory Factors Produced by Activated Lymph Nodes In Vivo.- Impairment of Antigen-Specific T Cell Proliferative Response in B Cell Suppressed Mice.- T Cell-Dependent B Cell Lymphoproliferation and Activation Induced by the Drug Diphenylhydantoin.- Negative Selection of Discrete Subgroups of T Helper Cells Restricted by Determinants Present on I-A and I-A/E Molecules.- Induction and Suppression of Delayed-Type Hypersensitivity to Sheep Red Blood Cells by Anti-Idiotypic Antiserum.- Genes of the Major Hisompatibility Complex Control Transmission of Information Between Initiator and Recruited T Lymphocyte.- The Role of I-J Subregion Gene Products in the Inhibition of Delayed-Type Hypersensitivity to Major Hisompatibility Antigens by Specific Suppressor T Cells.- Nonspecific Suppression of Anti-Graft Immunity by Antigen-Specific T Suppressor Cells.- Cell-Interactions in the Splenic Suppression Caused by Antigen-Feeding.- Autoimmune Disease Strongly Resembling Systemic Lupus Erythematosus (SLE) in F1 Mice Undergoing Graft-Versus-Host Reaction (GVHR).- Impaired Host Resistance Against Local JMV Marek’s Disease Tumors After Thymectomy and After Bursectomy.- Lack of Suppressor T Cells in Renal Transplant Recipients and Activation by Aminophylline.- Secondary In Vivo Cytotoxic T Cell Responses To Minor Hisompatibility Antigens.- Cellular and Genetic Basis of the Relative Resistance to the Induction of Experimental Allergic Encephalomelitis (EAE) in Albino Oxford (AO) Rats.- Quantitative Aspects of the Nonspecific Humoral Immune Response to Sheep Erythrocytes.- The Effect of Cyclosporin A On Spontaneous Autoimmune Thyroiditis in Obese Strain (OS) Chickens.- Characteristics of IL-3 Derived and IL-3 Dependent Lymphocyte Cell Lines.- Developmental Aspects of T-Suppressor Cells Induced by Hapten-Carrier Conjugates.- Immune Response Regulation.- Session 8 The Still Unsolved Mystery of the Germinal Center (Continued).- Chairman’s Introduction.- The Role of T Cells in B Cell Priming and Germinal Centre Development.- Expression of T Cell Antigens by Cells in Mouse and Human Primary and Secondary Follicles.- Localization Patterns of Germinal Center Cell Subsets Differing in Density and in Sedimentation Velocity.- Surface Phenotype and Migratory Capability of Peyer’s Patch Germinal Center Cells.- Separation and Characterization of Tonsillar Germinal Centre Lymphocytes Using Peanut Lectin.- Non-lymphoid Cells from Rat Intentinal Lymph.- Effect of Immunological Adjuvants on the Appearance of Monocyte and Dendritic Cell Precursors in Rat Thoracic Duct Lymph.- Dendritic Reticulum Cell Sarcoma: A Rare Tumor of the Follicular Compartment.- Immunoperoxidase Analysis of B and T Cell Populations in Human Lymphoid Follicles.- Disparity Between Humoral Antibody Formation and Proliferative Reactions in Lymph Nodes: C57L/J vs. Haired and Hairless HRS/J Mice.- Isolation and Properties of Spleen Follicular Dendritic Cells.- Immunocytological Characterization of the Constituent Cells of the Secondary Nodules in Human Tonsils-II.- Lymph Macrophages Enter the Germinal Center of Regional Lymph Nodes.- Formation of Germinal Centers in the Rat Thymus.- Maturity of Precursor Cells for Germinal Centers.