Incorporating Annotation Data In Quantitative Trait Loci Mapping With Mrna Transcripts.

Overview

Microarrays allow measurements of the quantity of every mRNA transcript in a subject and of the particular versions of their genes. Understanding the relationship between a particular genetic location and its expression is fundamental to elucidating the relationships among genes, other genes' transcripts, and proteins translated from those transcripts. Currently, few statistical labs have developed models that use all available biological information. This research helps develop the knowledge base used ...
See more details below
Other sellers (Paperback)
  • All (2) from $73.48   
  • New (2) from $73.48   
Sending request ...

More About This Book

Overview

Microarrays allow measurements of the quantity of every mRNA transcript in a subject and of the particular versions of their genes. Understanding the relationship between a particular genetic location and its expression is fundamental to elucidating the relationships among genes, other genes' transcripts, and proteins translated from those transcripts. Currently, few statistical labs have developed models that use all available biological information. This research helps develop the knowledge base used by the 21st century's pioneering researchers in oncology, metabolic engineering and pharmacogenetics. To strengthen the available models, I introduced a biological distance based covariance matrix. Using simulated data, I examined the incorporation of biological distance in statistical genetics, specifically into expression quantitative trait loci mapping. I used receiver operator characteristic curves to compare these approaches, and generated recommendations for when it is advantageous to include annotation information into gene mapping. The greatest benefit arises in pleiotropic relationships where each transcript has low heritability, although using excessively noisy annotations is disadvantageous. These tools fill a small part of the gap in our understanding of the complex dynamical system that is molecular or systems biology.
Read More Show Less

Product Details

  • ISBN-13: 9781243615749
  • Publisher: BiblioLabsII
  • Publication date: 9/4/2011
  • Pages: 90
  • Product dimensions: 7.44 (w) x 9.69 (h) x 0.19 (d)

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)