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Induction And Segregation Of The Vertebrate Cranial Placodes / Edition 1
     

Induction And Segregation Of The Vertebrate Cranial Placodes / Edition 1

by Byung-Yong Park, Soojin Park, Daniel S. Kessler
 

ISBN-10: 1615041028

ISBN-13: 9781615041022

Pub. Date: 07/15/2010

Publisher: Morgan & Claypool Publishers

During evolution the vertebrate head has acquired a number of unique features including specialized paired sense organs and cranial sensory ganglia. These evolutionary novelties arise from discrete thickenings of the head ectoderm known as cranial placodes. They include the adenohypophyseal, olfactory, lens, trigeminal, profundal, otic, epibranchial and lateral

Overview

During evolution the vertebrate head has acquired a number of unique features including specialized paired sense organs and cranial sensory ganglia. These evolutionary novelties arise from discrete thickenings of the head ectoderm known as cranial placodes. They include the adenohypophyseal, olfactory, lens, trigeminal, profundal, otic, epibranchial and lateral line placodes. While distinct in the derivatives and cell types they will form, all cranial placodes originate from a common preplacodal domain surrounding the anterior neural plate. Recent evidence suggests that the induction of this pre-placodal domain and its subsequent subdivision into individual placodes with specific identities is a multi-step process. Here we describe the development of these placodes and their derivatives and summarize recent advances in the characterization of the repertoire of transcription factors underlying their development. We also review recent studies that have started to address the role of several classes of signaling molecules in placode induction and segregation, including Bone Morphogenetic Proteins, Fibroblast Growth Factors and Wnt molecules.

Product Details

ISBN-13:
9781615041022
Publisher:
Morgan & Claypool Publishers
Publication date:
07/15/2010
Series:
Colloquium Series on Developmental Biology Series
Pages:
90
Product dimensions:
7.30(w) x 9.10(h) x 0.30(d)

Table of Contents

Introduction 1

Cranial Placodes and Their Derivatives 5

Adenohypohyseal Placode 5

Olfactory Placodes 8

Lens Placodes 10

Profundal/Trigeminal Placodes 11

Otic Placodes 13

Epibranchial Placodes 15

Lateral Line Placodes 16

Hypobranchial Placodes 17

Molecular Identity of Cranial Placodes 19

Six and Eya Gene Families 21

Pax Gene Family 38

Induction and Segregation of the Cranial Placodes 41

Historical Perspective 42

A Common Domain for All Cranial Placodes 43

Lens, the Ground State of All Sensory Placodes 44

Inducing Factors in the Generation of Cranial Placodes 45

Bone Morphogenetic Protein Signaling 45

Fibroblast Growth Factor Signaling 46

Wnt Signaling 47

Other Signaling Pathways 48

Conclusion 51

Acknowledgments 53

References 55

Author Biographies 81

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