Infection and Autoimmunity

by Nancy Agmon-Levin (Editor), Yehuda Shoenfeld (Editor), Noel R. Rose (Editor)

Overview

Infection and Autoimmunity encompasses the different mechanisms involved in the infection-autoimmunity association/induction. Special attention is given to heat shock proteins (HSPs) and to transgenic mouse models to better understand infection-induced autoimmunity. Organized into six parts, this book first discusses the mechanisms of autoimmune induction by infection. Some chapters follow discussing the vaccination and vaccines, including the controversial issue of vaccine-autoimmunity relationship. Other chapters elucidate the relationship of bacteria and parasites to autoimmunity. Lastly, the aspects of infections and diseases are described. This reference material will help readers gain a deeper insight into the important etiological aspects of autoimmunity.

• The only book directed at the interactions between infectious agents and autoimmunity
• Describes the prevalence and incidence of the global issues and current therapeutic approaches
• Presents the measures for infection control
• Completely updated, with new chapters
• One-stop reference with easy access to topics

Product Details

ISBN-13:	9780080534657
Publisher:	Elsevier Science
Publication date:	09/18/2004
Sold by:	Barnes & Noble
Format:	eBook
Pages:	768
File size:	13 MB
Note:	This product may take a few minutes to download.

About the Author

Professor Yehuda Shoenfeld is the President of the Center for Autoimmune Diseases (present), incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel Aviv University (since 2002–Present), Emeritus Professor of the Sackler School of Medicine in Tel Aviv University and teaches medical studies and MSc and PhD students (since 1985). Prof. Shoenfeld has edited a series of textbooks entailing "The Mosaic of Autoimmunity," "Autoantibodies," "Infection and Autoimmunity," and "Diagnostic Criteria of Autoimmune Diseases" (Elsevier Pub.). He has served on 36 editorial boards and is the organizer of more than 25 international congresses on autoimmunity. He is the author of > 2000 peer-reviewed papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.

Nancy Agmon-Levin, MD is a senior lecturer at the Sackler Faculty of Medicine of the Tel-Aviv University. She is a graduate of Hadassah medical school in Jerusalem, Israel. Dr. Agmon-Levin has completed her residency in Internal Medicine and fellowship in allergy and clinical immunology at the Kaplan medical center in Israel. During the last 6 years she has worked as a senior physician and a scientist as well as the deputy head of the Zabludowicz Center for Autoimmune Diseases at the Sheba Medical Center in Israel. Dr. Agmon-Levin is the president of the Israeli association for Allergy and clinical immunology.

Dr. Agmon-Levin is active in research, training, education and patient care. She has over 100 peer reviewed publications mainly focusing on various fields of autoimmunity research, autoantibodies, roles of vitamin D, hormones and environmental factors as infectious agents and vaccines in the pathogenesis of autoimmune diseases.

Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University.

His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands.

He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity.

Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honored as Doctoris Honoris Causa, from Debrecen University (Hungary), and from 2009 he is honorary member of the Slovenian National Academy of Sciences. He has recently been awarded a Life Contribution Prize in Internal Medicine in Israel, 2012 as well as the ACR Master Award in 2013.

Prof. Shoenfeld has educated a long list of students (<25) being heads of departments and institutes.

Noel Rose was born in Stamford, Connecticut. He attended Yale University for his undergraduate education followed by the University of Pennsylvania for a Ph.D. and State University of New York at Buffalo for an MD. He was a member of the faculty of the State University of New York at Buffalo School of Medicine for a period of 20 years, rising through the ranks to become a professor of Microbiology and Medicine, Director of Clinical Laboratories and Director of the Center for Immunology. He then spent ten years at Wayne State University School of Medicine where he chaired the Department of Immunology and Microbiology. In 1981, he joined the faculty of Johns Hopkins University as chairman of the Department of Immunology and Infectious Diseases. He presently holds professorial appointments in the Departments of Pathology, Molecular Microbiology and Immunology, Medicine and Environmental Health Sciences at The Johns Hopkins University and directs the Center for Autoimmune Disease Research. Dr. Rose’s original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr. Rose is the author or co-author of over 800 scientific papers and editor or co-editor of 24 books. He has received numerous honors, including two honorary doctoral degrees, election to fellowship in national or international societies, service in national and international organizations and editorial boards of leading journals.

Table of Contents

List of Contributors

Introduction: Infection and Autoimmunity

I Mechanisms of Autoimmune Induction by Infection

Implications of T Cell Receptor Crossreactivity for the Pathogenesis of Autoimmune Diseases

Epitope Spreading

Molecular Mimicry in Multiple Sclerosis: Role of MHC-Altered Peptide Ligands (MAPL)

Adverse Events of Desirable Gain in Immunocompetence: The Immune Restoration Inflammatory Syndromes (IRIS)

CD5-Expressing B Cells and Infection

Endothelial Cell Autoreactivity and Infection

II Vaccination

Induction of Autoimmunity by Adjuvant Hydrocarbons

Vaccination and Autoimmunity

BCG Vaccination

III Viruses

Viruses: The Culprits of Autoimmune Diseases?

How Transgenic Mouse Models Contribute to a Better Understanding of Virus-Induced Autoimmunity

Epstein-Barr Virus and Autoimmunity

HIV and Autoimmunity

Parvovirus B19 Infection and Its Association to Autoimmune Disease

Hepatitis C Infection and Vasculitis

HCV and Cryoglobulinemia

Virus-Induced Systemic Vasculitides

Viral Infections and Autoimmune Hepatitis

Viral Infections and Type 1 Diabetes

Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease (TMEV-IDD) and Autoimmunity

Viruses and Multiple Sclerosis

Endogenous Retroviruses as Etiological Agents in Systemic Lupus Erythematosus

Sjögren's Syndrome - Autoimmune Epithelitis: Role of Coxsackieviruses in Pathogenesis

Viral Infection and Heart Disease: Autoimmune Mechanisms

IV Bacteria and Autoimmunity

Rheumatic Fever: How Streptococcal Throat Infection Triggers an Autoimmune Disease

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)

Helicobacter Pylori Infection and Gastric Autoimmunity: Coincidence or Cause-Effect Relationship?

Yersinia Enterocolitica Infections and Autoimmune Thyroid Diseases

Reactive Arthritis (Reiter's Syndrome): Roles of Infection, HLA-B27 and the Immune Response

Bovine Spongiform Encephalopathy as an Autoimmune Disease Evoked by Acinetobacter: Implications for Multiple Sclerosis and Creutzfeldt-Jakob Disease

Infection and Autoimmunity in Patients with Antibiotic Treatment-Resistant Lyme Arthritis

Post-Infectious Arthritis: Reactive Arthritis or Slow Infectious Arthritis?

V Parasites and Autoimmunity

Parasitic Infection and Autoimmunity

Autoimmunity in Chagas' Disease

Anti-Saccharomyces Cerevisiae Antibodies and Autoimmune Diseases

VI Infection and Diseases

The Infectious Origin of the Antiphospholipid Syndrome

SLE and Infections

Type I Diabetes Mellitus, Infection and Toll-like Receptors

Infection and Autoimmune Thyroid Diseases

Pemphigus and Infection

Infection, Autoimmunity and Autoimmune Liver Diseases

Infections and Vasculitis

Infection and Multiple Sclerosis

Infections and Polymyositis-Dermatomyositis

Infection and Guillain-Barré Syndrome

Infection and Systemic Sclerosis

Tuberculosis and SLE-like Symptoms as a Complication of Biological Anti-TNF Therapy

Infection and Behçet's Syndrome

Infections and Immune Thrombocytopenic Purpura

Inflammatory Bowel Disease

Infection and Spondyloarthropathies

Celiac Disease and Infection

Infections Associated with Retinal Autoimmunity

Infection and Atherosclerosis

The Pathogenic Role of Heat Shock Proteins in Atherosclerosis

Interaction between Rheumatoid Arthritis and Infections

Subject Index

What People are Saying About This

From the Publisher

Fully revised and updated text encompasses the different mechanisms involved in the infection-autoimmunity association and induction

Editorial Reviews

Reviewer: Joseph R. Lentino, MD, PhD (Loyola University Stritch School of Medicine)
Description: This is the second edition of a compilation of ideas by experienced scientists about autoimmune illness as it relates to infectious pathogens. The first edition was published in 2004.
Purpose: While undoubtedly several infectious agents have been linked to subsequent autoimmune events in individual patients, it cannot be said that every individual develops an autoimmune illness subsequent to infection with the offending pathogen. So, there must be more to the development of autoimmune illness in humans than exposure to or infection by microbes. The purpose of this book is to explore those factors which may play a role in the development of autoimmune illness.
Audience: This is appropriate for scientists in the field of immunology, virology, molecular biology, and molecular genetics. It also should be available for students of the basic sciences in the field of medicine. Clinicians who have a serious interest in conducting research in these fields of study will do well to read and discuss with their doctoral level colleagues the ideas and mechanisms proposed in this book. The book is not appropriate for medical students.
Features: Over 1.000 pages of text explain and speculate on the development of autoimmune illness related to a variety of pathogens, including bacteria, viruses, protozoa, helminths, fungi, etc. The authors of each chapter make salient arguments in support of their hypotheses for the causation of such diseases as rheumatological illness, thyroiditis, diabetes, gastrointestinal illness, encephalopathies, neurological illness, dermatological conditions, renal and hepatic disease, to name but a few. Some of the explanations are, in my judgment, speculative and yet unproven, but deserving of future investigation. Several chapters have helpful diagrams, tables, or illustrations which serve to explain the exact mechanism being proposed. The references are current and appropriate.
Assessment: As a practitioner of clinical infectious disease, I found some of the chapters to be more than what I need to know in caring for patients, so while the cytokine response to S. pyogenes may be fundamental to the development of molecular mimicry, that only helps if, by understanding the mechanism, we can learn to abrogate the consequences of infection. Maybe sometime in the future that will be reality. My hope is that younger students will explore these ideas and bring them full circle to the clinic.

Doody's Review Service