Infections Causing Human Cancer: Softcover Edition / Edition 1 by Harald zur Hausen | 9783527329779 | Paperback | Barnes & Noble
Infections Causing Human Cancer: Softcover Edition / Edition 1

Infections Causing Human Cancer: Softcover Edition / Edition 1

by Harald zur Hausen
     
 

ISBN-10: 3527329773

ISBN-13: 9783527329779

Pub. Date: 12/28/2010

Publisher: Wiley

Infections must be thought as one of the most important, if not the most important, risk factors for cancer development in humans. Approximately 15-20% of all cases of cancer around the world are caused by viruses. The establishment of a causal relationship between the presence of specific infective agents and certain types of human cancer represents a key step in

Overview

Infections must be thought as one of the most important, if not the most important, risk factors for cancer development in humans. Approximately 15-20% of all cases of cancer around the world are caused by viruses. The establishment of a causal relationship between the presence of specific infective agents and certain types of human cancer represents a key step in the development of novel therapeutic and preventive strategies.

In this book, Professor zur Hausen (Nobel Prize in Physiology/Medicine 2008) provides a thorough and comprehensive overview on carcinogenic infective agents — viruses, bacteria, parasites and protozoons — as well as their corresponding transforming capacities and mechanisms. The result is an invaluable and instructive reference for all oncologists, microbiologists and molecular biologists working in the area of infections and cancer.

The author was among the first scientists to reveal the cervical cancer-inducing mechanisms of human papilloma viruses and isolated HPV16 and HPV18, and, as early as 1976, published the hypothesis that wart viruses play a role in the development of this type of cancer.

Product Details

ISBN-13:
9783527329779
Publisher:
Wiley
Publication date:
12/28/2010
Pages:
531
Product dimensions:
6.70(w) x 9.40(h) x 1.10(d)

Table of Contents

HISTORICAL REVIEW
The Early Period (1898-1911)
Frustration and Successes (1912-1950)
The Period from 1950 to 1965
A First Human Tumor Virus?
The Difficult 1970s
The Re-emergence of a Concept
THE QUEST FOR CAUSALITY
Infectious Agents as Direct Carcinogens
Infectious Agents as Indirect Carcinogens
TUMORS LINKED TO INFECTIONS -
SOME GENERAL ASPECTS
Tumor Types Linked to Infections
Global Contributions of Infections to Human Cancer
Host Interactions with Potentially Carcinogenic Infections
HERPESVIRUSES AND ONCOGENESIS
Alphaherpesviridae
Betaherpesviridae
Gammaherpesviridae
PAPILLOMAVIRUSES -
A MAJOR CAUSE OF HUMAN CANCERS
Introduction
Concept of Viral Interfering Cascades
Cancers Linked to HPV Infections
Role of Co-factors
Preventive Vaccination
Therapeutic Vaccination
Therapy
HEPADNAVIRUS FAMILY
Hepatitis B Virus
Animal Hepadnaviruses
FLAVIVIRUS FAMILY
Hepatitis C Virus
RETROVIRUS FAMILY
Human T-lymphotropic Retroviruses 1 (HTLV-1)
Human T-lymphotropic Retroviruses 2 (HTLV-2)
Human Endogenous Retroviruses
Gibbon Ape Leukaemia Virus and Simian Sarcoma Virus
OTHER VIRUS INFECTIONS POSSIBLY INVOLVED IN HUMAN CANCERS
Polyomaviruses (JC, BK and SV40)
HELICOBACTER, CHRONIC INFLAMMATION AND CANCER
Discovery, Taxonomy and Genomics
Life Cycle, Specificity, and Virulence Determinants in Cancer Development
Prevention of H. Pylori Induced Cancer
Animal Models
Virulence Determinants of Enterohepatic Helicobacter Spp
Enterohepatic Helicobacter Spp. -
Are they Cocarcinogens?
PARASITES AND HUMAN CANCER
Schistosomiasis
Infection with Liver Flukes (Opisthorchis Viverrini, O. Felineus, Clonorchis Sinensis)
CANCERS WITH A POSSIBLE INFECTIOUS ETIOLOGY
Leukemias and Lymphomas
Human Breast Cancer
Other Human Cancers Possibly Linked to Infectious Events

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