Infectious Disease: Pathogenesis, Prevention and Case Studies / Edition 1

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“… a fun and readable book that engages the imagination and retains the interest of the clinically oriented reader while conveying an understanding of the direct implications of molecular characteristics of infectious agents to the practice of medicine..” –Emerging Infectious Diseases, January 2010

“… provides a valuable overview of the basic principles and issues pertaining to the pathogenesis and prevention of infectious diseases. The illustrations, the chapter summaries with relevant information, and the case studies are all particularly useful for the targeted readers. The book is well designed and manages to convey the general concepts of the various aspects of infectious diseases without overwhelming the reader with too much information… recommended for students, trainees, or physicians who desire a well-illustrated textbook that is easy to read and that addresses the basic aspects of infectious disease.” –Clinical Infectious Diseases, 2010

The study of infectious diseases has undergone major changes since its infancy when it was largely a documentation of epidemics. It has now evolved into a dynamic phenomenon involving the ecology of the infectious agent, pathogenesis in the host, reservoirs and vetors, as well as the complex mechanisms concerned in the spread of infection and the extent to which this spread occurs. Rapid globalization has led to unprecedented interest in infectious diseases worldwide and their effect on complex population dynamics including migration, famine, fire, war, and terrorism. It is now essential for public health officials to understand the basic science behind infectious disease and, likewise, students studying ID must have a broader understanding of the implications of infectious disease in a public health context as well as clinical presentation and prevention. The clear demand for an integrated approach has led to the publication of this text.

Check out the student companion site at

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Editorial Reviews

From the Publisher
"All three of these pictures are excellent, both for beauty andillustration." (The Quarterly Review of Biology, 1 September2011)

“A fun and readable book that engages the imagination andretains the interest of the clinically orientated reader whileconveying an understanding of the direct implications of molecularcharacteristics of infectious agents to the practise ofmedicine.”

Louisa Chapman, Emerging Infectious Diseases, January 2010 

“This book provides a valuable overview of the basicprinciples and issues pertaining to the pathogenesis and preventionof infectious diseases. The illustrations, the chapter summarieswith relevant information, and the case studies are allparticularly useful for the targeted readers. The book is welldesigned and manages to convey the general concepts of the variousaspects of infectious diseases without overwhelming.”

Stella U. Kalu and Tasnee Chonmaitree, Clinical infectiousdiseases, January 2010

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Product Details

  • ISBN-13: 9781405135436
  • Publisher: Wiley
  • Publication date: 5/18/2009
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 664
  • Product dimensions: 8.80 (w) x 11.00 (h) x 1.40 (d)

Meet the Author

Nandini Shetty is an MD, FRCPath, MSc (Epidemiology andStatistics). She is an Honorary Senior Lecturer at the Royal Freeand University College London Medical School and she is uniquelywell-qualified for authorship of this book as she has hadexperience teaching infectious disease from all three perspectives,basic science, public health and medical. Her clinical activitiesinclude the diagnosis and management of community and hospitalacquired infection at the University College London Group ofHospitals. As a member of the faculty of the Health ProtectionAgency she has an important role in managing the Public Healthaspects of Communicable Disease in the UK.

Julian Wei-Tze Tang is a PhD, MRCP, FRCPath, ConsultantVirologist at the National University Hospital in Singapore. He isa clinical/academic virologist interested in all aspects(pathogenesis, diagnosis, management, control and epidemiology) ofviruses that can cause disease in humans - particularly HIV,influenza, and newly emerging viruses. He completed all hisspecialist training in the UK and has worked and taught students inLondon, Hong Kong, and Singapore.

Julie Andrews is an MRCP FRCPath, ConsultantMicrobiologist at the Whittington Hospital in London. She completedher training from University College and other affiliated hospitalsin London. Her current position involves the diagnosis andmanagement of infection in the community and the hospital andincludes infection prevention and control. She also hasresponsibility for tutoring medical students from the Royal Freeand University College London Medical School.

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Table of Contents


1. Microbial etiology of disease N. Shetty, E. Aarons, J.Andrews.

2. Structure and function of microbes N. Shetty, E. Aarons,J. Andrews.

3. Host defence versus microbial pathogenesis and the mechanismsof microbial escape N. Shetty, E. Aarons, J. Andrews.

4. Diagnosis of microbial infection N. Shetty, E. Aarons, J.Andrews.

5. General Principles of Antimicrobial Chemotherapy N.Shetty, E. Aarons, J. Andrews.

6. Basic concepts of the epidemiology of infectious diseasesN. Shetty.


7. Infections of the skin, soft tissue, bone and joint N.Shetty, J.W. Tang.

8. Gastroenteritis N. Shetty, J.W. Tang.

9. Cardiac and Respiratory Tract infections N. Shetty, J.W.Tang, J. Andrews.

10. Infections of the Central Nervous System N. Shetty, J.W.Tang.

11. Infections of the Genito-urinary System N. Shetty, R.Smith.


12. Obstetric, Congenital and Neonatal Infections N. Shetty,J.W. Tang, J. Andrews.

13. Infections in the immunocompromised host (HIV, solid organtransplant recipients, haematological malignancies) D. Mack, N.Shetty.

14. Health care associated infections N. Shetty.

15. The fever and rash conundrum: rashes of childhood J.W.Tang.


16. Tuberculosis S. Srivastava, N. Shetty.

17. Malaria D. Mack.

18. HIV/AIDS J.W. Tang.

19. Hepatitis J.W. Tang.

20. Influenza J.W. Tang, P.K.S. Chan.

21. Infections in the returning traveler N. Shetty.


22. Viral hemorrhagic fevers J.W. Tang.

23. Emerging infections I (Human monkeypox, Hantaviruses, Nipahvirus, Japanese encephalitis, Chikungunya) J.W. Tang.

24. Emerging infections II (West Nile virus, Dengue, SevereAcute Respiratory Syndrome-Associated Coronavirus) J.W. Tang,P.K.S. Chan.

25. Diphtheria N. Shetty.

26. Agents of Bioterrorism J.W. Tang .


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