The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects -- Workshop Summary

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In recent years, a number of chronic diseases have been linked, in some cases definitively, to an infectious etiology: peptic ulcer disease with Helicobacter pylori, cervical cancer with several human papillomaviruses, Lyme arthritis and neuroborreliosis with Borrelia burgdorferi, AIDS with the human immunodeficiency virus, liver cancer and cirrhosis with hepatitis B and C viruses, to name a few. The proven and suspected roles of microbes does not stop with physical ailments; infections are increasingly being examined as associated causes of or possible contributors to a variety of serious, chronic neuropsychiatric disorders and to developmental problems, especially in children.

The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects, summarizes a two-day workshop held by the Institute of Medicine’s Forum on Microbial Threats to address this rapidly evolving field. Participants explored factors driving infectious etiologies of chronic diseases of prominence, identified difficulties in linking infectious agents with chronic outcomes, and discussed broad-based strategies and research programs to advance the field.

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Product Details

  • ISBN-13: 9780309089944
  • Publisher: National Academies Press
  • Publication date: 6/15/2004
  • Pages: 236
  • Product dimensions: 6.06 (w) x 9.02 (h) x 0.54 (d)

Table of Contents

Summary and assessment 1
1 Defining the relationship : an examination of infectious agents associated with chronic diseases 13
The role of viruses in oncogenesis : human papillomaviruses and cervical cancer as a paradigm 17
Chronic hepatitis B virus infections 28
Infectious agents and cardiovascular disease 36
Demyelinating diseases 45
Common infections and uncommon disease : elusive associations of enteroviruses and type I diabetes mellitus 52
Infectious agents and schizophrenia 59
Ovine pulmonary adenocarcinoma : identifying the causative agent for a neoplastic disease and implications for human lung cancer 66
Propionibacterium acnes and chronic diseases 74
2 Endemic infectious diseases linked to chronic diseases : implications for developing countries 81
Potential long-term consequences of early childhood enteric and parasitic infections 83
Infectious agents and epilepsy 93
Control of infectious causes of childhood disability in developing countries 99
HTLV-1 : clinical impact of a chronic infection 110
Progression of hepatitis C virus infection with and without schistosomiasis 120
Interactions of multiple infectious agents in malaria-endemic areas : concurrent HIV-AIDS and malaria 126
3 Obstacles and opportunities for framing future research 135
Pathogens and disease : issues in determining causality 140
Exploring the genetic background-environment interplay in an animal model of neurodevelopmental disorders : a multidisciplinary approach 150
Infection, cancer, and the immune response 154
4 Opportunities to prevent and mitigate the impact of chronic diseases caused by infectious agents 174
Developing vaccines for prevention of chronic disease 175
Toward a strategic approach : integrating epidemiology, laboratory research, and surveillance; setting priorities 183
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