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From The CriticsReviewer: John F. Moran, MD(Loyola University Stritch School of Medicine)
Description: Written by 37 international experts, this book discusses many aspects of inflammation and its importance in the development of atherosclerosis.
Purpose: The purpose is to review and update information that can define the pathologic role of inflammation in the development of atherosclerosis.
Audience: The book would appeal to basic and clinical investigators as well as cardiologists. Cardiology fellows and trainees would find some pertinent information as well.
Features: The book's 16 chapters address various aspects of the inflammatory process in atherosclerosis. There is a good pathologic description of the vulnerable plaque from rupture erosion to healed plaque, with the accumulation of foam cells. There is an interesting chapter on transplantation-associated vascular arteriopathy. There is an interesting discussion on the importance of myocardial occlusion and reperfusion and how that is associated with an inflammatory reaction. Free radicals and oxidative stress and other reactive oxygen species are also discussed. The importance of oxidized LDL and its association with diabetes, hypertension, and hyperlipidemia is reviewed. The interaction of oxidized LDL particles and hemoxygenase-1 is developed in a chapter. The importance of lymphocytes from natural kilolymphocytes to activated lymphocytes and their effect on collagen synthesis, most notably in the fibrous cap, is covered. Infectious agents and antibiotic treatment for atherosclerosis is reviewed.
Assessment: There is much data here regarding markers of atherosclerosis and the inflammatory response that accompanies it, from the development of fatty streaks to full-blown atherosclerotic plaques. This book brings its audience up to speed on the cellular/molecular development of atherosclerosis with an emphasis on pathologic development. This excellent book is a good companion and follow-up to Dr. Valentine Fuster's American Heart Association monograph, The Vulnerable Atherosclerotic Plaque: Understanding, Identification, and Modification (Futura Publishing Co., 1999).