Inflammatory Diseases of the Central Nervous System

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Interactions between the immune and nervous systems are involved in many disease processes. Modulation of inflammation can provide an important opportunity to enhance regeneration within the central nervous system. This authoritative book defines the key cellular players in mounting an inflammatory response and highlights critical factors in the target organ that influence the nature of that response and its capacity either to damage or protect the brain. Several key clinical areas are highlighted - particularly autoimmune diseases of the nervous system including multiple sclerosis, as well as microbiological and traumatic challenges; the book therefore provides both a summary of the basic science background as well as practical, clinical-friendly guidelines to management. The book will be of interest to a wide range of physicians, including neurologists, neurosurgeons, neurorehabilitationists, infectious disease physicians, and clinical neuroscientists, as well as neuroscientists and immunologists.

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Editorial Reviews

Doody's Review Service
Reviewer: Joseph I Sirven, MD (Mayo Clinic Arizona)
Description: This multiauthored book surveys the relationship between inflammation and neurological conditions, a particularly important topic given that many neurological diseases have inflammatory etiologies.
Purpose: The editors intended to convey a sense of excitement about the field of neuroimmunology and its unique nuances in the brain. The book also attempts to provide a modern understanding of the complex interaction between the immune system and the nervous system.
Audience: It is intended for practicing clinicians and all who have an interest in neurological conditions. The authors are all experts in their field.
Features: The book is organized into multiple sections starting with basic immunology followed by neuroinflammation pertaining to a number of sequelae, including infections and trauma. For a complex topic, the book is easy to read. Figures and diagrams leap off the page and are easy to follow. Inflammatory reactions to infections are especially well covered. The references are excellent. If there is any shortcoming, it is that the book provides an overview, not in-depth coverage of any particular topic.
Assessment: This excellent book surveys the burgeoning field of neuroimmunology. As such, it is a useful addition to the library. Future editions will need to devote more coverage to neuro-oncology and paraneoplastic syndromes.
From the Publisher
'There is no doubt that this book can serve as a basic textbook for graduate students and clinicians who seek to understand mechanisms of CNS inflammation and who wish to gain insight that will suggest future avenues of intervention, or explain events associated with existing therapies. Even readers with only a basic background in immunology can benefit greatly from this book.' The Lancet
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Product Details

  • ISBN-13: 9780521888745
  • Publisher: Cambridge University Press
  • Publication date: 12/31/2009
  • Pages: 282
  • Product dimensions: 7.60 (w) x 9.80 (h) x 0.80 (d)

Meet the Author

Trevor Kilpatrick is Professor of Neurology and Director of the Centre for Neuroscience at the University of Melbourne, leader of the MS Group at the Howard Florey Institute and Neurologist and Head of the MS Unit at the Royal Melbourne Hospital.

Richard M. Ransohoff is Director of the Neuroinflammation Research Center in the Department of Neurosciences at the Lerner Research Institute, Cleveland Clinic; Professor of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University; and Staff Neurologist in the Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, Ohio.

Steven Wesselingh is Professor of Microbiology and Medicine, Monash University, Melbourne.

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Table of Contents

Preface; Part I. Interactions Between the Immune and Nervous Systems: 1. Effectors and determinants of the innate and adaptive immune responses Edgar Meinl and Hartmut Wekerle; 2. Microglia: protective and pathogenic mediators Bevyn Jarrott and Karina Apricò; 3. The role of dendritic cells in neuroinflammation Heather Donaghy, Edwina J. Wright and Anthony L. Cunningham; 4. Negotiating the brain barriers: access of immune cells and pathogens into the CNS Britta Engelghardt; Part II. Autoimmunity: 5. Immune effector heterogeneity in multiple sclerosis and related CNS inflammatory demyelinating disorders Shaunu F. Roemer and Claudia F. Lucchinetti; 6. Multiple sclerosis: neuroimmune crosstalk in acute and progressive stages of the disease Martin Kerschensteiner and Reinhard Hohlfeld; 7. CD8+ T Cell-mediated autoimmune diseases in the CNS Lisa Walter and Matthew L. Albert; 8. Acute disseminated encephalomyelitis: determinants and manifestations Eppie M. Yiu and Andrew J. Kornberg; 9. Primary angiitis of the CNS and its mimics Tina Chadha, George F. Duna and Leonard H. Calabrese; Part III. Microbiological and Traumatic Challenges to the CNS: 10. Acute viral encephalitis: role of the immune system in viral clearance from the CNS and in the generation of pathology David N. Irani and Natalie Prow; 11. Chronic HIV infection of the CNS: role of the immune system in virological control and the generation of pathology Carolyn F. Orr and Bruce J. Brew; 12. Brain inflammation during bacterial meningitis Trine H. Mogensen and Lars Østergaard; 13. Parasitic infections of the brain: malaria and beyond Stephen J. Rogerson and Danny A. Milner Jr; 14. Role of the inflammatory process in traumatic brain damage Cristina Morganti-Kossmann, Laveniya Satgunaseelan, Nicole Bye, Phuong Nguyen and Thomas Kossmann; Part IV. Therapy: 15. HIV-associated neurocognitive disorders: clinical features and therapeutic challenges Nicoline Schiess and Justin C. McArthur; 16. Role of immunomodulation in management of infections of the CNS Miles H. Beaman; 17. Neuroinflammation: an emerging therapeutic target in neurological disease Joseph M. Antony and Christopher Power; Index.

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