Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management / Edition 1

Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management / Edition 1

by Alireza Minagar
     
 

Now well recognized, the critical role of the inflammatory response in the pathophysiology of peripheral and central neurological disorders, including Alzheimer's and Parkinson's diseases, is today the subject of intense investigation at the molecular level. In Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, a

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Overview

Now well recognized, the critical role of the inflammatory response in the pathophysiology of peripheral and central neurological disorders, including Alzheimer's and Parkinson's diseases, is today the subject of intense investigation at the molecular level. In Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, a panel of influential basic scientists review in detail the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidosis, HIV-associated dementia, and HTLV-associated neurological disorders.

Cutting-edge and authoritative, Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management offers basic research and clinical scientists an illuminating introduction to the new world of inflammatory CNS conditions and the emerging diagnostic and therapeutic opportunities they provide.

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Product Details

ISBN-13:
9781617375606
Publisher:
Springer-Verlag New York, LLC
Publication date:
11/19/2010
Series:
Current Clinical Neurology Series
Edition description:
Softcover reprint of hardcover 1st ed. 2005
Pages:
362
Product dimensions:
0.78(w) x 7.00(h) x 10.00(d)

Table of Contents

Endothelial Cell-Leukocyte Interactions During CNS Inflammation

J. Steven Alexander and Alireza Minagar

Multiple Sclerosis: A Disease of Miscommunication Between the Immune and Central Nervous Systems?

Monica J. Carson, Crystal S. Anglen, and Corinne Ploix

Cytokines and Brain: Health and Disease

Tammy Kielian and Paul D. Drew

Chemokines and Central Nervous System Disorders

William J. Karpus

Circulating Cell-Derived Microparticles in Thrombotic and Inflammatory Disorders

Wenche Jy, Lawrence L. Horstman, Joaquin J. Jimenez, Alireza Minagar, and Yeon S. Ahn

Multiple Sclerosis: Clinical Features, Immunopathogenesis, and Clinical Management

William A. Sheremata

Neuroprotective Effects of Interferon-b in Multiple Sclerosis

Fabrizio Giuliani, Rana Zabad, and V. Wee Yong

Acute Disseminated Encephalomyelitis

Sean J. Pittock and Dean M. Wingerchuk

Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis

Staley A. Brod

Neuromyelitis Optica

Dean M. Wingerchuk

Transverse Myelitis: Clinical Manifestations, Pathogenesis, and Management

Chitra Krishnan, Adam I. Kaplin, Deepa M. Deshpande, Carlos A. Pardo, and Douglas A. Kerr

Optic Neuritis: Pathogenesis, Immunology, Diagnosis, and Clinical Management

Robert Zivadinov and Rohit Bakshi

Central Nervous System Vasculitis: Pathogenesis, Immunology, and Clinical Management

Shariq Mumtaz, Marjorie R. Fowler, Eduardo Gonzales-Toledo, and Roger E. Kelley

Neurosarcoidosis: Pathogenesis, Immunology, and Clinical Management

Dakshinamurty Gullapalli and Lawrence H. Phillips, II

Neuropsychiatric SLE: Pathogenesis, Immunology, and Clinical Management

Deborah Aleman-Hoey and Robin L. Brey

Gene Expression in HIV-Associated Dementia

Paul Shapshak, Alireza Minagar, Elda M. Duran, Fabiana Ziegler, Wade Davis, Raman Seth, and Toni Kazic

Human T-Lymphotropic Virus-Associated Neurological Disorders: Pathogenesis, Immunology, and Clinical Management

Michael D. Lairmore, Bindhu Michael, Lee Silverman, and Amrithraj Nair

West Nile Virus Infection of the Nervous System: Pathogenesis, Immunology, and Clinical Management

Douglas J. Lanska

Index

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