Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management / Edition 1

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Overview

A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

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Editorial Reviews

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"The objective of this book is to provide the readers with a highly detailed review of the basic principles of neuroinflammation and extensive updates of the latest findings on common neuroinflammatory disorders. … The treatment principles of the different inflammatory disorders are very well covered and up-to-date. This book can be of interest for the institutional library in order for doctors to look up specific details and treatment principles, and to enter deeply into neuroimmunological basics." (Orvar Eeg-Olofsson, European Journal of Paediatric Neurology, Vol. 11, June, 2007)

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Product Details

  • ISBN-13: 9781617375606
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/19/2010
  • Series: Current Clinical Neurology Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2005
  • Edition number: 1
  • Pages: 362
  • Product dimensions: 0.78 (w) x 7.00 (h) x 10.00 (d)

Table of Contents

Endothelial Cell-Leukocyte Interactions During CNS Inflammation

J. Steven Alexander and Alireza Minagar

Multiple Sclerosis: A Disease of Miscommunication Between the Immune and Central Nervous Systems?

Monica J. Carson, Crystal S. Anglen, and Corinne Ploix

Cytokines and Brain: Health and Disease

Tammy Kielian and Paul D. Drew

Chemokines and Central Nervous System Disorders

William J. Karpus

Circulating Cell-Derived Microparticles in Thrombotic and Inflammatory Disorders

Wenche Jy, Lawrence L. Horstman, Joaquin J. Jimenez, Alireza Minagar, and Yeon S. Ahn

Multiple Sclerosis: Clinical Features, Immunopathogenesis, and Clinical Management

William A. Sheremata

Neuroprotective Effects of Interferon-b in Multiple Sclerosis

Fabrizio Giuliani, Rana Zabad, and V. Wee Yong

Acute Disseminated Encephalomyelitis

Sean J. Pittock and Dean M. Wingerchuk

Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis

Staley A. Brod

Neuromyelitis Optica

Dean M. Wingerchuk

Transverse Myelitis: Clinical Manifestations, Pathogenesis, and Management

Chitra Krishnan, Adam I. Kaplin, Deepa M. Deshpande, Carlos A. Pardo, and Douglas A. Kerr

Optic Neuritis: Pathogenesis, Immunology, Diagnosis, and Clinical Management

Robert Zivadinov and Rohit Bakshi

Central Nervous System Vasculitis: Pathogenesis, Immunology, and Clinical Management

Shariq Mumtaz, Marjorie R. Fowler, Eduardo Gonzales-Toledo, and Roger E. Kelley

Neurosarcoidosis: Pathogenesis, Immunology, and Clinical Management

Dakshinamurty Gullapalli and Lawrence H. Phillips, II

Neuropsychiatric SLE: Pathogenesis, Immunology, and Clinical Management

Deborah Aleman-Hoey and Robin L. Brey

Gene Expression in HIV-Associated Dementia

Paul Shapshak, Alireza Minagar, Elda M. Duran, Fabiana Ziegler, Wade Davis, Raman Seth, and Toni Kazic

Human T-Lymphotropic Virus-Associated Neurological Disorders: Pathogenesis, Immunology, and Clinical Management

Michael D. Lairmore, Bindhu Michael, Lee Silverman, and Amrithraj Nair

West Nile Virus Infection of the Nervous System: Pathogenesis, Immunology, and Clinical Management

Douglas J. Lanska

Index

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