Inherited Susceptibility to Cancer: Clinical, Predictive and Ethical Perspectivesby William D. Foulkes, Shirley V. Hodgson
Pub. Date: 03/19/2009
Publisher: Cambridge University Press
Many cancers, both common and rare, are known to have a hereditary predisposition. Recent advances in genomics have clarified the risks, and in some cases the mechanisms, of cancer developing in an individual. This volume covers all the key issues in cancer genetics, reviewing both the technology behind genetic risk assessment and the ethical dilemmas it poses. The first of two parts deals with ethical, legal, and social issues, with chapters on counseling, screening, and gene and mutation identification. The second part systematically outlines current knowledge of the inheritance patterns of many different cancer types, both from a site-by-site perspective and for special groups. With a final chapter highlighting late-breaking developments, this up-to-date and authoritative volume will be of great interest to the specialist as well as other professionals in the areas of primary care, counseling, and cancer risk assessment.
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Table of ContentsPart I. Ethical, legal and social issues, screening, counselling, gene and mutation detection: 1. The inherited basis of cancer Shirley Hodgson and Gareth Evans; 2. Screening for cancer in those at high risk as a result of genetic susceptibility Howard Cuckle; 3. Ethical and legal perspectives on inherited cancer susceptibility Bartha Maria Knoppers and Beatrice Godard; 4. Cancer genetics and public expectations Dorothy Nelkin; 5. Genetic counselling June Peters; 6. Cancer genetics in primary care Gene Feder and Michael Modell; 7. Genetic epidemiologic approaches to finding genes that influence susceptibility to cancer Pamela St. Jean and Nicholas Schork; 8. Mutation detection Louise Hosking, Karin Au and Philippe Schork; Part II. Hereditary contribution to cancer: site-by-site and special groups: 9. Cancers of the digestive system Tamar Flanders and William Foulkes; 10. Cancers of the breast, ovary and uterus William Foulkes and Steven Narod; 11. Cancers of the kidney and urothelium Eamonn Maher; 12. Cancers of the prostate and testes Steven Narod, Bonnie King and David Hogg; 13. The neurofibromatoses and other neuro-oncological syndromes Martin Ruttledge and Guy Rouleau; 14. Malignant melanoma Nicholas Hayward; 15. Non-melanoma skin cancer David Goudie; 16. Endocrine cancers Harriet Feilotter and Lois Mulligan; 17. Tobacco-related cancers of the respiratory and upper digestive tract Zoltan Trizna and Stimson Schantz; 18. Inherited abnormalities of DNA processing and predisposition to cancer A. Malcolm Taylor; 19. Childhood cancer Kathy Pritchard-Jones; 20. Late-breaking developments William Foulkes and Shirley Hodgson; Index.
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