Inherited Susceptibility to Cancer: Clinical, Predictive and Ethical Perspectives

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Many cancers, both common and rare, are known to have a hereditary predisposition. Recent advances in genomics have clarified the risks, and in some cases the mechanisms, of cancer developing in an individual. This volume covers all the key issues in cancer genetics, reviewing both the technology behind genetic risk assessment and the ethical dilemmas it poses. The first of two parts deals with ethical, legal, and social issues, with chapters on counseling, screening, and gene and mutation identification. The second part systematically outlines current knowledge of the inheritance patterns of many different cancer types, both from a site-by-site perspective and for special groups. With a final chapter highlighting late-breaking developments, this up-to-date and authoritative volume will be of great interest to the specialist as well as other professionals in the areas of primary care, counseling, and cancer risk assessment.

The book contains black-and-white illustrations.

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Editorial Reviews

From the Publisher
'Outlines succinctly our current knowledge of the inheritance patterns of many different cancer types. Such information needs to be readily available to counsel patients and their families in cancer clinics and increasingly in the primary care setting. This authoritative book will be of great use to all professionals involved in providing cancer care.' Karol Sikora, Imperial College School of Medicine

'Foulkes and Hodgson have assembled a group of visionary contributors who not only portray the state of cancer genetics, but also provide helpful glimpses of the future for clinicians and researchers alike.' Francis S. Collins, National Human Genome Research Institute

New England Journal of Medicine
The book gives an up-to-date account of current knowledge about the cancer genes identified in the various familial cancer syndromes....It provides epidemiologic data and figures on increased relative risks in cases without clearly identified genetic causes and with a presumed multifactorial type of inheritance combined with variable sensitivity to environmental exposure. More important, it places "cancer susceptibility" in its proper social context.
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Product Details

  • ISBN-13: 9780521104746
  • Publisher: Cambridge University Press
  • Publication date: 3/19/2009
  • Edition description: Reissue
  • Pages: 472
  • Product dimensions: 5.98 (w) x 9.02 (h) x 1.06 (d)

Table of Contents

Part I. Ethical, legal and social issues, screening, counselling, gene and mutation detection: 1. The inherited basis of cancer Shirley Hodgson and Gareth Evans; 2. Screening for cancer in those at high risk as a result of genetic susceptibility Howard Cuckle; 3. Ethical and legal perspectives on inherited cancer susceptibility Bartha Maria Knoppers and Beatrice Godard; 4. Cancer genetics and public expectations Dorothy Nelkin; 5. Genetic counselling June Peters; 6. Cancer genetics in primary care Gene Feder and Michael Modell; 7. Genetic epidemiologic approaches to finding genes that influence susceptibility to cancer Pamela St. Jean and Nicholas Schork; 8. Mutation detection Louise Hosking, Karin Au and Philippe Schork; Part II. Hereditary contribution to cancer: site-by-site and special groups: 9. Cancers of the digestive system Tamar Flanders and William Foulkes; 10. Cancers of the breast, ovary and uterus William Foulkes and Steven Narod; 11. Cancers of the kidney and urothelium Eamonn Maher; 12. Cancers of the prostate and testes Steven Narod, Bonnie King and David Hogg; 13. The neurofibromatoses and other neuro-oncological syndromes Martin Ruttledge and Guy Rouleau; 14. Malignant melanoma Nicholas Hayward; 15. Non-melanoma skin cancer David Goudie; 16. Endocrine cancers Harriet Feilotter and Lois Mulligan; 17. Tobacco-related cancers of the respiratory and upper digestive tract Zoltan Trizna and Stimson Schantz; 18. Inherited abnormalities of DNA processing and predisposition to cancer A. Malcolm Taylor; 19. Childhood cancer Kathy Pritchard-Jones; 20. Late-breaking developments William Foulkes and Shirley Hodgson; Index.

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