Inhibitors of the Ras Superfamily G-proteins, Part A

Overview

This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

Key features:

• Contributions from leading authorities

• Informs and updates on all the latest developments in the field

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Inhibitors of the Ras Superfamily G-proteins, Part A

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Overview

This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

Key features:

• Contributions from leading authorities

• Informs and updates on all the latest developments in the field

Read More Show Less

Product Details

  • ISBN-13: 9780124167490
  • Publisher: Elsevier Science
  • Publication date: 9/10/2013
  • Pages: 364
  • Product dimensions: 6.20 (w) x 9.00 (h) x 0.90 (d)

Table of Contents

  1. The Ras superfamily G-proteins
    Fuyuhiko Tamanoi
  2. NMR Study to Identify a Ligand-Binding Pocket in Ras
    Till Maurer and Weiru Wang
  3. The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules
    Christian W. Johnson and Carla Mattos
  4. State 1(T) Inhibitors of Activated Ras
    Hans Robert Kalbitzer and Michael Spoerner
  5. Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface
    Alessandro Di Domizio and Francesco Peri
  6. Development of EHop-016, a Small Molecule Inhibitor of Rac
    Suranganie Dharmawardhane
  7. Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors
    Susanne Schmidt and Anne Debant
  8. Targeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways
    Anne Blangy and Philippe Fort
  9. Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase
    Dominico Vigil and Channing J. Der
  10. A Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF Interaction
    Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis
  11. Inhibitors of K-Ras Plasma Membrane Localization
    Kwang-jin Cho, Dharini van der Hoeven and John F. Hancock
  12. Ras Chaperons: New Targets for Cancer and Immunotherapy
    Yoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor
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