Inside the O'Briens: A Novel

Inside the O'Briens: A Novel

4.6 44
by Lisa Genova

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A Library Journal Best Books of 2015 Pick

A St. Louis Post-Dispatch Best Books of 2015 Pick

A GoodReads Top Ten Fiction Book of 2015

A People Magazine Great Read

From award-winning, New York Times bestselling author and neuroscientist Lisa Genova comes a “heartbreaking…very human novel” (Matthew


A Library Journal Best Books of 2015 Pick

A St. Louis Post-Dispatch Best Books of 2015 Pick

A GoodReads Top Ten Fiction Book of 2015

A People Magazine Great Read

From award-winning, New York Times bestselling author and neuroscientist Lisa Genova comes a “heartbreaking…very human novel” (Matthew Thomas, author of We Are Not Ourselves) that does for Huntington’s disease what her debut novel Still Alice did for Alzheimer’s.

Joe O’Brien is a forty-three-year-old police officer from the Irish Catholic neighborhood of Charlestown, Massachusetts. A devoted husband, proud father of four children in their twenties, and respected officer, Joe begins experiencing bouts of disorganized thinking, uncharacteristic temper outbursts, and strange, involuntary movements. He initially attributes these episodes to the stress of his job, but as these symptoms worsen, he agrees to see a neurologist and is handed a diagnosis that will change his and his family’s lives forever: Huntington’s disease.

Huntington’s is a lethal neurodegenerative disease with no treatment and no cure, and each of Joe’s four children has a 50 percent chance of inheriting their father’s disease. While watching her potential future in her father’s escalating symptoms, twenty-one-year-old daughter Katie struggles with the questions this test imposes on her young adult life. As Joe’s symptoms worsen and he’s eventually stripped of his badge and more, Joe struggles to maintain hope and a sense of purpose, while Katie and her siblings must find the courage to either live a life “at risk” or learn their fate.

Praised for writing that “explores the resilience of the human spirit” (The San Francisco Chronicle), Lisa Genova has once again delivered a novel as powerful and unforgettable as the human insights at its core.

Editorial Reviews

Matthew Thomas
"This heartbreaking book tells the whole story of how a major illness affects a family. Genova’s gift is to show that things do work out, in a sense. Her very human novel teaches us to keep living, to lean on each other and be there to be leaned on.”
"This novel of siblings rocked by their father's Huntington's disease is a total tearjerker, but ultimately it's a tribute to family love."
Marie Claire
"An intimate, heartbreaking look at life with Huntington's disease."
People Magazine
"Genova...compassionately details how an illness—this time Huntington's disease—can destroy not only the afflicted, but those who love them as well."
The Washington Post
“An unsparing, heart-piercing portrait…compelling.”
US Weekly
"A moving drama."
"Compelling and masterful."
"Inside the O'Briens is...about resilience and hope."
Shelf Awareness
"Sympathetic, absorbing, multifaceted characters compel the reader's compassion. While Genova's background in neuroscience allows her to portray medical issues accurately, the heart of the O'Briens' story is human....Poignant and painful, warm and redemptive, Inside the O'Briens displays Genova's established strengths in bringing neuroscience to the lay reader, and portraying the power of love."
Huffington Post
"Inside the O'Briens . . . promises to do for Huntington's disease, what Still Alice did for Alzheimer's."
Barbara Shapiro
"Lisa Genova’s deep empathy for her characters shines through this poignant and uplifting story about family, grief and the resilience of the human spirit. Kudos to this amazing writer for showing us—once again—the transformative powers of even the most devastating events. Do not miss this fabulous novel."
Jacquelyn Mitchard
"For the characters in a Lisa Genova novel, there is no way out, for genetic destiny has sealed their fate. And yet, for us as readers, there also is no way out, for we have no desire to look away. In his fear and courage, Joe O’Brien is an American hero. Huntington’s disease will claim his life, but not his capacity to love. This is Genova’s genius. A bold, skillful writer at the height of her narrative powers, she makes us long to hope for the hopeless and comfort the condemned. In their hard journeys, we find the small shining promise of every single ordinary day."
Vanessa Diffenbaugh
"Lisa Genova’s subtle, finely tuned prose gains momentum until you don’t know whether to laugh, cry, or give thanks. Like all of her work, Inside the O’Briens is brimming with candor, pathos, and deeply human characters. I didn't want the book to end!"

Product Details

Gallery Books
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5.30(w) x 8.20(h) x 1.10(d)

Read an Excerpt

Inside the O'Briens


    Damn woman is always moving his things. He can’t kick off his boots in the living room or set his sunglasses down on the coffee table without her relocating them to “where they belong.” Who made her God in this house? If he wants to leave a stinking pile of his own shit right in the middle of the kitchen table, then that’s where it should stay until he moves it.

    Where the fuck is my gun?

    “Rosie!” Joe hollers from the bedroom.

    He looks at the time: 7:05 a.m. He’s going to be late for roll call if he doesn’t get the hell out of here pronto, but he can’t go anywhere without his gun.

    Think. It’s so hard to think lately when he’s in a hurry. Plus it’s a thousand degrees hotter than hell in here. It’s been sweltering for June, in the high eighties all week, and barely cools down at night. Terrible sleeping weather. The air in the house is a thick swamp, today’s heat and humidity already elbowing in on what was trapped inside yesterday. The windows are open, but that doesn’t help a lick. His white Hanes T-shirt is sticking to his back beneath his vest, pissing him off. He just showered and could already use another.

    Think. He took a shower and got dressed—pants, T-shirt, Kevlar vest, socks, boots, gun belt. Then he took his gun out of the safe, released the trigger lock, and then what? He looks down at his right hip. It’s not there. He can feel the missing weight of it without even looking. He’s got his magazine pouch, handcuffs, Mace, radio, and service baton, but no gun.

    It’s not in the safe, not on his dresser, not in the top drawer of his dresser, not on the unmade bed. He looks over at Rosie’s bureau. Nothing but the Virgin Mary centered on an ivory doily. She sure ain’t going to help him.

    St. Anthony, where the fuck is it?

    He’s tired. He worked traffic detail last night over at the Garden. Friggin’ Justin Timberlake concert got out late. So he’s tired. So what? He’s been tired for years. He can’t imagine being so tired that he would be careless enough to misplace his loaded gun. A lot of guys with as many years on the force as Joe grow complacent about their service weapon, but he never has.

    He stomps down the hall, passes the two other bedrooms, and pokes his head into their only bathroom. Nothing. He storms into the kitchen with his hands on his hips, the heel of his right hand searching for the top of his gun out of habit.

    His four not-yet-showered, bed-headed, sleepy teenagers are up and seated around the tiny kitchen table for breakfast—plates of undercooked bacon, runny scrambled eggs, and burnt white toast. The usual. Joe scans the room and spots his gun, his loaded gun, on the mustard-yellow Formica counter next to the sink.

    “Mornin’, Dad,” offers Katie, his youngest, smiling but shy about it, sensing that something is off.

    He ignores Katie. He picks up his Glock, secures it in its holster, and then aims the crosshairs of his wrath at Rosie.

    “Whaddaya doin’ with my gun there?”

    “What are you talking about?” says Rosie, who is standing by the stove in a pink tank top and no bra, shorts, and bare feet.

    “You’re always movin’ my shit around,” says Joe.

    “I never touch your gun,” says Rosie, standing up to him.

    Rosie is petite at five feet nothing and a hundred pounds soaking wet. Joe’s no giant either. He’s five feet nine with his patrol boots on, but everyone thinks of him as being taller than he is, probably because he’s barrel-chested and has muscular arms and a deep, husky voice. At thirty-six, he’s got a bit of a gut, but not bad for his age or considering how much of his life he spends sitting in a cruiser. He’s normally playful and easygoing, a pussycat really, but even when he’s smiling and there’s that twinkle in his blue eyes, everyone knows he’s old-school tough. No one messes with Joe. No one but Rosie.

    She’s right. She never touches his gun. Even after all these years of his being on the force, she’s never grown comfortable with having a firearm in the house, even though it’s always in the safe or in his top dresser drawer, where it’s trigger-locked, or on his right hip. Until today.

    “Then how the fuck did it get there?” he asks, pointing to the space next to the sink.

    “Watch your mouth,” she says.

    He looks over at his four kids, who have all stopped eating to witness the show. He narrows in on Patrick. God love him, but he’s sixteen going on stupid. This would be just the kind of knucklehead move he would pull, even after all the lectures these kids have endured about the gun.

    “So which one of you did this?”

    They all stare and say nothing. The Charlestown code of silence, eh?

    “Who picked up my gun and left it by the sink?” he demands, his voice booming. Silence will not be an option.

    “Wasn’t me, Dad,” says Meghan.

    “Me either,” says Katie.

    “Not me,” says JJ.

    “I didn’t do it,” says Patrick.

    What every criminal he’s ever arrested says. Everyone’s a fuckin’ saint. They all look up at him, blinking and waiting. Patrick shoves a rubbery slice of bacon into his mouth and chews.

    “Have some breakfast before you go, Joe,” says Rosie.

    He’s too late to have breakfast. He’s too late because he’s been looking for his goddamn gun that someone took and then left on the kitchen counter. He’s late and feeling out of control, and he’s hot, too hot. The air in this cramped room is too soupy to breathe, and it feels as if the heat from the stove and six bodies and the weather is stoking something already threatening to boil over inside him.

    He’s going to be late for roll call, and Sergeant Rick McDonough, five years younger than Joe, is going to have a word with him again or maybe even write him up. He can’t stomach
    the humiliating thought of it, and something inside him explodes.

    He grabs the cast-iron skillet on the stove by the handle and sidearms it across the room. It smashes a sizable hole in the drywall not far from Katie’s head, then lands with a resounding BANG on the linoleum floor. Rusty brown bacon grease drips down the daisy-patterned wallpaper like blood oozing from a wound.

    The kids are wide-eyed and silent. Rosie says nothing and doesn’t move. Joe storms out of the kitchen, down the narrow hallway, and steps into the bathroom. His heart is racing, and his head is hot, too hot. He splashes cold water over his hair and face and wipes himself dry with a hand towel.

    He needs to leave now, right now, but something in his reflection snags him and won’t let go.

    His eyes.

    His pupils are dilated, black and wide with adrenaline, like shark eyes, but that’s not it. It’s the expression in his eyes that has him arrested. Wild, unfocused, full of rage. His mother.

    It’s the same unbalanced gaze that used to terrify him as a young boy. He’s looking in the mirror, late for roll call, glued to the wretched eyes of his mother, who used to stare at him just like this when she could do nothing else but lie in her bed in the psych ward at the state hospital, mute, emaciated, and possessed, waiting to die.

    The devil in his mother’s eyes, dead for twenty-five years, is now staring at him in the bathroom mirror.

  • Meet the Author

    Lisa Genova is the author of the New York Times bestsellers Love Anthony, Left Neglected, and Still Alice, which has been adapted into a film starring Julianne Moore.

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    Inside the O'Briens 4.6 out of 5 based on 0 ratings. 44 reviews.
    Anonymous More than 1 year ago
    I just love reading Lisa Genova books.  She tells a great story which has you laughing and crying.  She definitely makes you think twice before judging  people  that  you may see on the street that are different from you.  I would highly recommend this book .  I was sorry to see it come to an end.  Look forward to her next one.
    AnnieMcDonnell More than 1 year ago
    WOW! Lisa Genova is a genius! My Emotions ran high when you read this story. It is a truly haunting, gut-wrenching story of a family you will fall in love with, and never forget. As I write this review, I find that my heart is still saddened by the story and the reality of Huntington’s Disease (HD). An illness I never heard of. An unthinkable illness. I fatal illness. An illness that finally has a voice! Lisa Genova truly got “inside” the minds of the six members of the O’Brien family in a hauntingly beautiful way. It was often startling how well she captured the daunting thoughts of each characters mind after the father’s diagnosis of Huntington’s Disease. We are introduced to the O’Briens, your typical Irish Catholic family living in Boston. Joe and Rosie are the parents of four children in their 20’s (JJ, Katie, Meghan and Patrick). They all live together in a 3-story house in the Charlestown suburb of Boston. Joe is a Boston police officer missing out on a lot of events and holidays with his family due to his job. Because of this, he is often thinking about with the time he will be able to spend with his family once he is retired, but all of that changes in an instant. Joe and Rosie are stunned when Joe is diagnosed with HD. I felt the same pang of shock he and Rosie did when the doctor told them he had HD. I could not imagine the pain someone would feel in his shoes, but I have to say that Lisa Genova tells you what is on his mind, and that of every O’Brien in a truly riveting way…You will feel as if you are an O’Brien. This story revolves around Joe’s diagnosis of HD and all that happens in the wake of it. Each family member deals with the diagnosis differently, and we are brought in to the minds of each person’s reality. I often had to remind myself that this was a work of fiction, because it was so real. So riveting. This story will grab you by the heart and not let go, even after you put the book down. A tear is running down my cheek. I am grateful for my healthy family.
    Sandy5 More than 1 year ago
    Peel back the wallpaper and look inside the life of the O’Briens, and what you will find will be extraordinary. I never imagined that this novel would be so inspiring and life-changing for me. I have been informed, enlightened and entertained. Knowing very little about this disease, I have become aware how Huntington’s Disease can affect a person and those around them. This novel is truly amazing. I laughed, I cried and I had many ahh moments. I can tell you this, don’t read this book on an airplane, the plane’s not dark enough to hide your swollen eyes from the tears, and I myself, didn’t pack enough tissues to last the whole flight. But, the plane’s engines are loud enough to drown out your snobs, that is one good thing. The story centers on Joe who is a police officer and his family. Throughout the book the author enlightens us with facts about Huntington’s Disease, nothing too heavy, just the facts to help us understand the story. The children have all grown up yet they all live together in their childhood home, each occupying their own space on a separate floor of the house with the parents who are still living in the home. Living in a small town, Joe loves his job as a police officer and their life was good until Joe starts to behave differently. His concentration is off, he’s having muscle spasms and other people start to notice that he’s just not acting the same. That trip to the doctor changes the life of the O’Briens forever. I feel chills’ writing this, for it’s that moment in life, where you can’t turn back time; it’s only going forward and making the best of the situation at hand. For the O’Briens, this family is a unit and as Joe has to face of the reality of what Huntington’s Disease is and how his life will change; he is not alone, not ever. Huntington’s Disease, it affects your family no matter if you want it to or not and for Joe’s family, this is a time where he may feel alone but his family is there. The emotions and the struggles are real, their fight is real and I was there with them. A couple of my favorite parts were the anger and fight that Joe went through. He didn’t give up, thinking about the symptoms that he was struggling with and yet he fought them because he didn’t want to give up what he loved. I also loved how Rosie, his wife was the only religious one in the family before this battle began. As time progressed, Joe disease became progressively worse and as a result, Joe started to high-five the Virgin Mary. The table turned and Joe wanted to believe in something higher and wanted to have hope, while Rosie started to drink and wondered how her God could allow such bad things to happen. It was such a wonderful story about family, about their struggles and about love. I highly recommend this novel. I was given a copy of this book from NetGalley in exchange for an honest opinion.
    Anonymous More than 1 year ago
    Thank you for bringing attention to Huntington's Disease! Both my father and my little sister have HD. I also have a 50% chance of having it as well. It is not well recognized and I appreciate you bringing to light the struggles people with HD go thrpugh.
    PagesofComfort More than 1 year ago
    I received a free copy of this ebook in exchange for an honest review.  Just like Still Alice, this book completely drew me in. Genova takes on another serious, but taboo, neurological disease. Huntington's Disease affects roughly 30,000 people in the united states. It doesn't sound like a lot compared to many of the other disease in this world, like breast cancer and Alzheimer's. But nevertheless, it's incredibly serious and deadly. But no one wants to talk about it.  Genova introduces us to the O'Briens; Joe, his wife Ruth, and their four children: JJ, Meghan, Katie and Patrick. When Joe finds out he has HD, his children are left with the choice of finding out whether they are gene positive or gene negative. JJ and Meghan find out, but Katie and Patrick don't. The book takes us through finding out Joe has HD, to watching his disease slowly take over his body. And throughout this, Katie struggles with whether she wants to find out if she's HD gene positive or negative.  I really liked how this book went back and forth between Katie and Joe's perspective. We watch Joe struggle with his growing symptoms and learning how to cope. And Katie struggles with her decision to find out about her future. The entire family copes with the disease so differently and I think it really shows how this disease can affect so many different people in different ways. No one is the same and the disease doesn't necessarily affect people the same.  Genova is definitely a new favorite author of mine. I loved Still Alice and Inside the O'Briens lived up to my expectations. I can't wait to read her other work and I continue to recommend her books to my friends. I can't say enough good things about the awareness she is bringing to these terrible diseases. 
    BettyTaylor More than 1 year ago
    I have not yet read Lisa Genova’s two previous books, but I certainly will now. The O’Brien family is one that most people can relate to. The father Joe is a policemen. Oldest son JJ is a fireman, and he and his wife have just gotten pregnant with their first child. Daughter Meghan is a ballet dancer. Katie teaches yoga. Patrick, the youngest, is basically a goof-off. Typical family, until Joe starts dropping things, begins having violent outbursts and involuntary muscular movements. He finally is diagnosed with Huntington’s Disease. According to an Internet site, Huntington's disease (HD) is an inherited disorder that affects the brain. Each person whose parent has HD has a 50% chance of inheriting the disorder. Onset of symptoms range from 35-50 years old. Juvenile cases occur in people less than 20 years of age. Symptoms are mild at first and are often barely noticeable but usually worsen over 15-20 years. Physical symptoms may include: abnormal body movements that worsen over time, including sudden jerks or uncontrolled movements of the limbs or trunk, facial grimacing, walking that is unsteady or dance-like; difficulty with eating, dressing, sitting, and caring for oneself; difficulty swallowing, grunting or poor articulation of speech, weight loss. Lisa Genova did an amazing job of writing how Joe slowly descends into a life obsessed with HD. With great sensitivity, she explores how each member of the family deals with the news. Each of the children struggle with the decision of whether to be tested or not. The fear the entire family has that the unborn baby may have inherited the gene felt so real. Ms. Genova also has the family learning to depend upon friends in time of greatest need. Joe, once a very proud man, now has to deal with the horrified looks he gets from people due to loss of control of his own body. But his fellow police buddies have his back. Joe actually comes up with a humorous way of dealing with people’s stares. Loved it! The courage of the family and how each member chooses to deal with the future was just so realistic. However I thought I would feel, some member of the family describes feeling the same way. These characters are so very real. They are not perfect; they reveal their fears, their anger, their confusion. They could be our neighbors, our friends, or they could be us.
    Anonymous More than 1 year ago
    Loved it.
    Anonymous More than 1 year ago
    This was awesome book and i am a nurse of 20 years and hsve only seen HD once, this book has so many emotions and is great!
    Anonymous More than 1 year ago
    Knowing someone personally with Huntington's, this was a very powerful book.
    Anonymous More than 1 year ago
    Good story I got to know and love the characters. Hoping there is a part two with this family.
    Splashesintobooks1 More than 1 year ago
    Superb, moving, family story This is an amazing book, totally unexpected to me and I am so grateful to the author, publishers and NetGalley, too, for letting me read an ARC in exchange for an honest review.  Joe O’Brien is a police officer who starts to suffer from uncharacteristic behaviour and emotional outbursts. When he eventually agrees to see a neurologist the results have severe impacts on his life and that of his family….he has Huntington’s Disease (HD). As they (and the reader) learn more about the disease, the 50% risk that his offspring will also develop it and the consequences of having it has on both life expectancy and quality.  The author explores the emotions of all the characters and their different reactions in such a powerful manner that I was enthralled with it all. It is so easy to empathise with them all because of the skilled portrayal and clearly very well researched knowledge of the author. This isn’t a quick escape into a chicklit, this is a very moving and inspiring story, one that continues to live with the reader long after they’ve finished reading. I have no hesitation in highly recommending it!
    anonomas More than 1 year ago
    And very good!
    Anonymous More than 1 year ago
    This was a gripping story with wonderful character development.  A generally depressing topic, but the author presents a realistic, inspirational insight into family members facing an unfathomable future. Highly recommend.
    Anonymous More than 1 year ago
    As someone who knows a little about Huntington's Disease as the spouse of someone who has tested positive but not symptomatic, I was apprehensive about this story. My experience is that HD is usually just glossed over in a story or a lot of misinformation is provided. That is not the case with this book. Lisa Genova has done a wonderful job of telling the truth about the disease and not sugar coating it. She has also done a great job of telling the story from not just the person diagnosed, but also as someone who is "at risk" and all the ins and outs of taking that test. I would highly recommend this book to anybody to read. And I thank you, Lisa Genova, for doing the research and telling a true to life story of a family dealing with Huntington's Disease. It is greatly appreciated. 
    Palegirl 11 days ago
    I'm a big fan of Lisa Genova's writing. I've read and loved each of her novels, and Inside the O'Briens did not disappoint. Ms. Genova writes compassionately without being overly-sentimental. She tackles big topics dealing with neurological diseases and disorders, and manages to educate without making you feel like you're being educated. She's never overly-technical and weaves the details into the storylines. Inside the O'Briens takes us into the world of the little known and little understood world of Huntington's Disease. It's a devastating genetic disease with a 100% death rate. This is the kind of story that has you asking yourself, "What would I do in this situation?" and you find that there are no easy answers. Even more, you realize you really can't know what you'd do or how you would feel unless you were in the situation yourself. The O'Briens are such a nice, normal, hard-working family that you want to meet them and befriend them. And you will generally care about what happens to them and the choices they make.
    Anonymous More than 1 year ago
    Anonymous More than 1 year ago
    Great read . At first I was disappointed at the end but then realized it had to end the way it dif. Really enjoy this authors work. I also read Still Alice. Will be looking for more of her bookd.
    Anonymous More than 1 year ago
    PierresFamily More than 1 year ago
    What a wonderful book! After reading Lisa Genova's moving book "Still Alice," I was eagerly awaiting her next labor of love, "Inside the O'briens." And it didn't disappoint.Genova presents the story of a family dealing with the devastating genetic effects of Huntington's Disease. She explores each character's respective reactions and decision processes.The characters are so well-developed and realistic, that I felt like I personally knew the family. Ms. Genova's knowledge and diligent research are obvious. I was sad to finish this book, and wish that we could continue the journey with the O'Brien family. However, I am aware that Ms. Genova has a new, important project to which we can look forward, a book about ALS. Every time I read one of her books, I am not only moved; I am informed, as well. She manages to teach us without being clinical about it; she is a gifted writer who fills a unique niche.
    RB5 More than 1 year ago
    Loved this book! All the characters were so interesting and well developed. However, I have to say I was disappointed in the ending. I hope there is a sequel.
    ToManyBooksNotEnoughTime More than 1 year ago
    I would like to thank Gallery Books & NetGalley for granting me a copy of this e-ARC to read in exchange for an honest review. Though I received this e-book for free that in no way impacts my review. Having read "Still Alice" I'll admit I went into this book with exceedingly high expectations, and I'm more than happy to say I wasn't disappointed in any way. If possible this book surpasses "Still Alice." Huntington's Disease has far less media exposure than Alzheimer's, but to me in many ways it is worse because you know what's coming and are mentally present for most of it. Plus the fact that it is a hereditary disease makes it exponentially harder, for many people don't show symptoms and therefore go undiagnosed until they already have a family of their own. Children that have a fifty percent chance of inheriting this living death sentence. Once again Genova tackles a tremendously challenging topic and handles it with grace and dignity, yet never shying away from the brutal reality of this disease. Her characters are already flawed, and when you suddenly throw such an explosive shock into the mix things are bound to suddenly go sideways for everyone. It's how each of the family members copes with this life altering news that makes this tale so powerful and real. Change the names and occupations and this could be anyone's story - mine, your's, your next door neighbor's. . . Though much of the story is told from Joe's and Katie's perspectives, none of those directly impacted are neglected. Between her deft handling of each character and the skillful arc of the overall story Genova has created a masterpiece that will stand the test of time. Even if we ever do find a cure for this insidious killer, this story will stand testament to not only those not lucky enough to survive long enough to benefit from the cure, but all the lives they touched along their journey. Be prepared to fall in love with the characters, to hate them, to get frustrated by them; in short to feel for them as you might feel about your own family members (by blood or choice). Keep tissues on hand, but don't be surprised to find yourself laughing out loud either, as you will run the gamut of human emotions while experiencing this story - both as you read it and well after you've finished it. I simply can't say enough good things about this powerfully moving tale, and I know that though it may take time to fully absorb all the details of this story, I'll be ready and waiting for Genova's next book!
    Darlene67 More than 1 year ago
    A quick read. Heart wrenching but very enjoyable.
    chemepsu More than 1 year ago
    As usual for this author, another great book!
    Anonymous More than 1 year ago
    Anonymous More than 1 year ago