Insulin Action / Edition 1

Insulin Action / Edition 1

by Ashok K. Srivastava
     
 

ISBN-10: 0792381130

ISBN-13: 9780792381136

Pub. Date: 05/28/1998

Publisher: Springer US

In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic

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Overview

In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.

Product Details

ISBN-13:
9780792381136
Publisher:
Springer US
Publication date:
05/28/1998
Series:
Developments in Molecular and Cellular Biochemistry Series, #24
Edition description:
1998
Pages:
194
Product dimensions:
8.27(w) x 10.98(h) x 0.02(d)

Table of Contents

Preface1
The IRS-signalling system: A network of docking proteins that mediate insulin action3
Role of binding proteins to IRS-1 in insulin signalling13
Insulin regulation of the Ras activation/inactivation cycle23
Insulin signal transduction through protein kinase cascades31
Protein phosphatase-1 and insulin action49
Insulin receptor internalization and signalling59
Spatial determinants of specificity in insulin action65
Binding of SH2 containing proteins to the insulin receptor: A new way for modulating insulin signalling73
Insulin receptor-associated protein tyrosine phosphatase(s): Role in insulin action79
Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases91
Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction101
Multifunctional actions of vanadium compounds on insulin signalling pathways: Evidence for preferential enhancement of metabolic versus mitogenic effects109
Regulation of the Na+/K+-ATPase by insulin: Why and how?121
Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin135
Metabolic and therapeutic lessons from genetic manipulation of GLUT4143
Insulin action in skeletal muscle from patients with NIDDM153
Genetic manipulation of insulin action and [beta]-cell function in mice161
TNF-[alpha] and insulin resistance: Summary and future prospects169
Membrane glycoprotein PC-1 and insulin resistance177
Insulin action on protein phosphatase-1 activation is enhanced by the antidiabetic agent pioglitazone in cultured diabetic hepatocytes185
Index to Volume 182193

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