Insulin Action / Edition 1

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In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.

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Editorial Reviews

Contains papers from a 1996 conference held at the University of Toronto in honor of the 75th anniversary of the discovery of insulin in 1921. The first group of papers delineates early signaling events following the binding of insulin to its receptor. A second group of papers addresses factors involved in modulating IRK function. A third group of papers looks at the effect of insulin and other agents on target tissues, and a final group deals with pathogenic considerations responsible for Type II diabetes. Co-published as , vol. 182, nos. 1 & 2, May 1998. No index. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

Table of Contents

Preface 1
The IRS-signalling system: A network of docking proteins that mediate insulin action 3
Role of binding proteins to IRS-1 in insulin signalling 13
Insulin regulation of the Ras activation/inactivation cycle 23
Insulin signal transduction through protein kinase cascades 31
Protein phosphatase-1 and insulin action 49
Insulin receptor internalization and signalling 59
Spatial determinants of specificity in insulin action 65
Binding of SH2 containing proteins to the insulin receptor: A new way for modulating insulin signalling 73
Insulin receptor-associated protein tyrosine phosphatase(s): Role in insulin action 79
Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases 91
Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction 101
Multifunctional actions of vanadium compounds on insulin signalling pathways: Evidence for preferential enhancement of metabolic versus mitogenic effects 109
Regulation of the Na+/K+-ATPase by insulin: Why and how? 121
Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin 135
Metabolic and therapeutic lessons from genetic manipulation of GLUT4 143
Insulin action in skeletal muscle from patients with NIDDM 153
Genetic manipulation of insulin action and [beta]-cell function in mice 161
TNF-[alpha] and insulin resistance: Summary and future prospects 169
Membrane glycoprotein PC-1 and insulin resistance 177
Insulin action on protein phosphatase-1 activation is enhanced by the antidiabetic agent pioglitazone in cultured diabetic hepatocytes 185
Index to Volume 182 193
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