Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System

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Product Details

  • ISBN-13: 9781468453829
  • Publisher: Springer US
  • Publication date: 3/28/2012
  • Edition description: Softcover reprint of the original 1st ed. 1987
  • Pages: 368
  • Product dimensions: 7.00 (w) x 10.00 (h) x 0.76 (d)

Table of Contents

Section I: Insulin Receptors: Structure and Function.- Internalization of Insulin and Its Receptor: Role in Signaling.- Insulin-activated Phosphorylation on Tyrosine of a 15 Kilodalton Cytosolic Protein in 3T3-L1 Adipocytes.- Role of Protein Phosphorylation in Growth Factor Signal Transduction..- The Processing and Transport of Peptide Hormones across Endothelial Cell Barriers.- The Role of Phospholipid Metabolism in Insulin Action.- Glucose Transporters: Overview and Implications for the Brain.- Alteration of Insulin Receptor Binding and Protein Kinase Activity in Rat Liver and Placenta by—-Naphthoflavone.- Section II: Insulin and Insulin Receptors in the Central Nervous System.- Evolution of Insulin and Insulin Receptors.- Evidence for Central Nervous System Insulin Synthesis.- Localization of Insulin to Neuronal Cells.- Synthesis of Insulin or a Similar Peptide in the Pituitary Gland and in Retinal Muller Cells.- Insulin in the Central Nervous System: A Regulator of Appetite and Body Weight.- Insulin in the Brain: A Feedback Loop Involving Brain Insulin and Circumventricular Organs.- Structural Evidence for a Subtype of Insulin Receptor in the Central Nervous System.- Physiologically Unique Insulin Receptors on Neuronal Cells.- Insulin Receptors in Brain Development.- Insulin Downregulates Alpha-2-adrenergic Receptors in Cultured Glial Cells.- Section III: Insulin-Like Growth Factor and Insulin-Like Growth Factor Receptors in the Central Nervous System.- Somatomedins (Insulin-like Growth Factors) and the Nervous System.- Insulin-like Growth Factor Receptors in the Brain.- Receptors for Insulin and Insulin related Peptides in the CNS: Studies of Localization in Rat Brain.- Visualization of IGF-2 Receptors in Rat Brain.- Insulin-like Growth Factors and Their Receptors in the Pituitary and Hypothalamus.- Two Types of Receptors for Insulin-like Growth Factors Are Expressed on Normal and Malignant Cells from Mammalian Brain.- Role of Insulin, Insulin-like Growth Factors and Nerve Growth Factor in Neurite Formation.- Contributors.- Author Index.

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