Part I. Genetic and Environmental Factors Affecting Insulin Action. Genetics of Insulin Resistance, Michael P. Stern and Braxton D. Mitchell. Ethnic Variation in Insulin Resistance and Risk of Type 2 Diabetes, Paul M. McKeigue. Fetal Effects on Insulin Resistance and Glucose Tolerance,Paul M. McKeigue. Obesity and Insulin Resistance: Epidemiologic, Metabolic, and Molecular Aspects, Jean-Pierre Despr&e's and André Marette. The Role of Body Fat Distribution in Insulin Resistance, Abhimanyu Garg. Physical Activity and Insulin Resistance in Man, Flemming Dela, Kári Mikines, and Henrik Galbo. Insulin Resistance in Smokers and Other Long-Term Users of Nicotine, Björn Eliasson and Ulf Smith. Part II. Pathophysiology of Insulin Resistance. Insulin Resistance and Inhibitors of Insulin Receptor Tyrosine Kinase, Jack F.Youngren, Ira D. Goldfine, Vincenzo Trischitta, and Betty A. Maddux. NMR Studies on the Mechanism of Insulin Resistance, Gianluca Perseghin, Kitt Falk Petersen, and Gerald I. Shulman. Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms, Lawrence J. Mandarino. The Role of the Liver in Insulin Action and Resistance, Jerry Radziuk and Susan Pye. The Pathophysiological Consequences of Adipose Tissue Insulin Resistance, Gerald M. Reaven. Insulin Action and Endothelial Function, Alain D. Baron and Michael J. Quon. Part III. Clinical Syndromes Associated with Insulin Resistance. Insulin Resistance and Dyslipidemia: Implications for Coronary Heart Disease Risk, Ami Laws. Insulin Resistance and Blood Pressure, Ele Ferrannini. Microalbuminuria and Insulin Resistance, Jeannie Yip and Roberto Trevisan. PAI-1, Obesity, and Insulin Resistance, Irène Juhan-Vague, Marie-Christine Alessi, and Pierre E. Morange. Insulin Resistance and Cardiovascular Disease, Aaron R. Folsom. Insulin Resistance Effects on Sex Hormones and Ovulation in the Polycystic Ovary Syndrome, John E. Nestler. Index.
Insulin Resistance: The Metabolic Syndrome X / Edition 1by Gerald M. Reaven
Pub. Date: 04/01/1999
Publisher: Springer-Verlag New York, LLC
Gerald Reaven, the discoverer of Syndrome X, and a panel of world-clas s investigators thoughtfully summarize our current understanding of ho w insulin resistance and its compensating hyperinsulinemia play a majo r role in the pathogenesis and clinical course of high blood pressure and cardiovascular diseaseythe so-called diseases of Western civilizat ion. These
Gerald Reaven, the discoverer of Syndrome X, and a panel of world-clas s investigators thoughtfully summarize our current understanding of ho w insulin resistance and its compensating hyperinsulinemia play a majo r role in the pathogenesis and clinical course of high blood pressure and cardiovascular diseaseythe so-called diseases of Western civilizat ion. These distinguished authorities detail, for the first time, the p athophysiological consequences and the clinical syndromes, excluding T ype 2 diabetes, related to insulin resistance. They also examine the g enetic and lifestyle factors that contribute to the wide differences i n insulin action that exist in the population at large. Timely and aut horitative, Insulin Resistance: The Metabolic Syndrome X illuminates t he full importance of insulin resistance as a major cause of hypertens ion, heart disease, and polycystic ovary syndrome.
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