Insulin Resistance: The Metabolic Syndrome X / Edition 1

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Overview

Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization. These distinguished authorities detail, for the first time, the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Timely and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the full importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome.

The book contains black-and-white illustrations.

Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease—the so-called diseases of Western civilization. These distinguished authorities detail, for the first time, the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Timely and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the full importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome.

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Editorial Reviews

New England Journal of Medicine
This book is an excellent and useful compendium of information about this rapidly moving field. It will be an essential addition to the libraries of those interested in any of the disorders linked to this prevalent metabolic state.
David A. Ehrmann
This volume in the Contemporary Endocrinology Series is a multiauthored text designed to summarize the current understanding of the importance of insulin resistance, particularly as it relates to non-diabetic states. The purpose is to provide the reader with information about the importance of insulin resistance in non-diabetic states. It is appropriate for any clinician or investigator who encounters adult patients. The spectrum of metabolic disturbances associated with insulin resistance is broad, making this book appealing to generalists as well as subspecialists. This book is structured in three parts. Part one covers genetic and environmental factors affecting insulin action; part two covers the pathophysiology of insulin resistance; and part three deals with clinical syndromes associated with insulin resistance. This book is particularly useful in that it bridges the gaps in what is known about the fundamental elements of insulin action and the clinical sequelae. For example, the complexities of the relationship between obesity and insulin resistance are clearly handled. This is an excellent and welcome addition to the field: concise, clearly written, and current.
Booknews
Reaven, who discovered Syndrome X, assembles summaries of the current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure, cardiovascular disease, and polycystic ovary syndrome. They detail the pathophysiological consequences and the clinical syndromes besides Type 2 diabetes that are related to insulin resistance, and explore the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Of interest to both researchers and clinicians. Annotation c. by Book News, Inc., Portland, Or.
Doody's Review Service
Reviewer: David A. Ehrmann, MD (University of Chicago Medical Center)
Description: This volume in the Contemporary Endocrinology Series is a multiauthored text designed to summarize the current understanding of the importance of insulin resistance, particularly as it relates to non-diabetic states.
Purpose: The purpose is to provide the reader with information about the importance of insulin resistance in non-diabetic states.
Audience: It is appropriate for any clinician or investigator who encounters adult patients. The spectrum of metabolic disturbances associated with insulin resistance is broad, making this book appealing to generalists as well as subspecialists.
Features: This book is structured in three parts. Part one covers genetic and environmental factors affecting insulin action; part two covers the pathophysiology of insulin resistance; and part three deals with clinical syndromes associated with insulin resistance. This book is particularly useful in that it bridges the gaps in what is known about the fundamental elements of insulin action and the clinical sequelae. For example, the complexities of the relationship between obesity and insulin resistance are clearly handled.
Assessment: This is an excellent and welcome addition to the field: concise, clearly written, and current.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781617370861
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/9/2010
  • Series: Contemporary Endocrinology Series , #12
  • Edition description: Softcover reprint of hardcover 1st ed. 1999
  • Edition number: 1
  • Pages: 374
  • Product dimensions: 10.00 (w) x 7.00 (h) x 0.80 (d)

Table of Contents

Part I. Genetic and Environmental Factors Affecting Insulin Action. Genetics of Insulin Resistance, Michael P. Stern and Braxton D. Mitchell. Ethnic Variation in Insulin Resistance and Risk of Type 2 Diabetes, Paul M. McKeigue. Fetal Effects on Insulin Resistance and Glucose Tolerance,Paul M. McKeigue. Obesity and Insulin Resistance: Epidemiologic, Metabolic, and Molecular Aspects, Jean-Pierre Despre's and André Marette. The Role of Body Fat Distribution in Insulin Resistance, Abhimanyu Garg. Physical Activity and Insulin Resistance in Man, Flemming Dela, Kári Mikines, and Henrik Galbo. Insulin Resistance in Smokers and Other Long-Term Users of Nicotine, Björn Eliasson and Ulf Smith. Part II. Pathophysiology of Insulin Resistance. Insulin Resistance and Inhibitors of Insulin Receptor Tyrosine Kinase, Jack F.Youngren, Ira D. Goldfine, Vincenzo Trischitta, and Betty A. Maddux. NMR Studies on the Mechanism of Insulin Resistance, Gianluca Perseghin, Kitt Falk Petersen, and Gerald I. Shulman. Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms, Lawrence J. Mandarino. The Role of the Liver in Insulin Action and Resistance, Jerry Radziuk and Susan Pye. The Pathophysiological Consequences of Adipose Tissue Insulin Resistance, Gerald M. Reaven. Insulin Action and Endothelial Function, Alain D. Baron and Michael J. Quon. Part III. Clinical Syndromes Associated with Insulin Resistance. Insulin Resistance and Dyslipidemia: Implications for Coronary Heart Disease Risk, Ami Laws. Insulin Resistance and Blood Pressure, Ele Ferrannini. Microalbuminuria and Insulin Resistance, Jeannie Yip and Roberto Trevisan. PAI-1, Obesity, and Insulin Resistance, Irène Juhan-Vague, Marie-Christine Alessi, and Pierre E. Morange. Insulin Resistance and Cardiovascular Disease, Aaron R. Folsom. Insulin Resistance Effects on Sex Hormones and Ovulation in the Polycystic Ovary Syndrome, John E. Nestler. Index.

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