Insulin Resistance, Metabolic Diseases and Diabetic Complications: Proceedings of the 7th European Symposium on Metabolism, Padova, September 30-October 3, 1998 / Edition 1

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Based on the proceedings of the 7th European Symposium on Metabolism in October 1998, this reference will be useful to doctors working with diabetic and cardiac patients. It reflects new research in which insulin resistance, previously only associated with type 2 diabetes and obesity, is recognized as being shared by a variety of conditions not necessarily associated with either malady, including hypertension, dyslipidemia, hyperuricemia, and others. The contributors include geneticists, epidemiologists, and physiopathologists, who provide an updated overview of the possible role of insulin resistance in pathogenesis of a group of major risk factors for cardiovascular disease. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780444500229
  • Publisher: Elsevier Science
  • Publication date: 7/28/1999
  • Series: ICS Series
  • Edition number: 1
  • Pages: 276

Table of Contents

Insulin resistance and systemic atherosclerosis 3
The Diabetes Intervention Study: impact of quality of risk factor control on coronary heart disease and mortality 9
Glucose, insulin and atherosclerosis: Lessons from the Bruneck Study 19
The plurimetabolic syndrome in the European population: the experience of the European Group on Insulin Resistance (EGIR) 25
Results of 10-years genetic studies in French families with type 2 diabetes 33
ACE genotype and diabetic nephropathy 37
Apolipoprotein E gene polymorphism, vascular complications and nephropathy in NIDDM 41
The atherogenic dyslipidemia of visceral obesity: need for preventive endocrinology 47
Molecular and cellular markers of insulin resistance and diabetic complications
Nitric oxide and arginine 55
Protein kinase C activation and the formation of diabetic vascular complications 61
Molecular basis of insulin receptor activation, signal transduction and signalling specificity 75
Regulation of metabolic gene expression by glucose 83
Insulin resistance, endothelium and diabetic complications
Endothelium and diabetes. Evidences for a relationship between metabolic control and inappropriate nitric oxide production 91
Effect of different lipoprotein fractions on nitric oxide and superoxide production in endothelial cells 99
Renal complications
Diabetic nephropathy in IDDM and NIDDM: functional studies 109
Diabetic nephropathy in Type 1 and Type 2 diabetes: structural studies 117
Cellular markers for diabetic nephropathy 129
Atherosclerotic complications
Dyslipidemia in diabetes: clinical importance of lipoprotein heterogeneity 137
Heterogeneity of triglyceride-rich lipoproteins in the postprandial state 143
The role of glycation in diabetic complications 147
Oxidative stress and diabetic complications 153
Triglycerides increase the biosynthesis of plasminogen activator inhibitor type I: focus on their mechanism of action 159
Altered fatty acid partitioning by PPAR activators improves glucose homeostatis; a case for PPAR[alpha] and [gamma] coagonists 167
Prevention of complications
The role of antihypertensive treatment in CHD prevention 175
Antihypertensive therapy and cardiovascular complications 181
Pharmacologic inhibition of the renin-angiotensin system and diabetic nephropathy 187
Calcium channel blockers and incipient diabetic nephropathy 193
Prevention of diabetic complications. Diet and cardiovascular disease: the epidemiological evidence 201
Effects of dietary fat and carbohydrate on insulin resistance 207
Secondary prevention of coronary heart disease in diabetes: a subgroup analysis of the Scandinavian Simvastatin Survival Study (4S) 213
HMG-CoA reductase inhibitors in atherosclerosis 219
Diabetes and atherosclerosis: a lipoprotein perspective 225
Metformin 231
Metformin and the treatment of the insulin resistance syndrome - The BIGPRO Studies 237
Mechanism of action of thiazozidinediones in type 2 diabetes 243
Leptin: a perspective for the weight control problem 253
Carnitine system and insulin resistance 259
Index of authors 275
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