Insulin Resistance: Childhood Precursors and Adult Disease / Edition 1

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The prevalence of disorders related to insulin resistance has continued to increase throughout the developed and developing world. The world's population has continued to become more obese and sedentary. Of great concern in the last decade is the extension of these deleterious lifestyle patterns to the pediatric population, leading to both obesity and the appearance of insulin resistance-related disorders in youth as well as adults. Insulin Resistance: Childhood Precursors and Adult Disease presents topics related to insulin resistance and its consequences across the lifespan. In the first section of the book examining epidemiology, the contributors review controversies over the definition of metabolic syndrome in adults and children, current knowledge regarding the epidemiology of insulin resistance in the pediatric population and the contributions of the prenatal and early childhood environment to the development of insulin resistance. The Second part of the book explores pathophysiology, with reviews of the techniques used to study insulin resistance, as well as current knowledge of the molecular and physiologic mechanisms of insulin resistance, including the contributions of adipose tissue and biochemical mediators. This section concludes with discussion of the relationship between insulin resistance and cardiovascular, endothelial, liver and gonadal disorders. The final section of the book explores the impact of exercise and weight loss medications on insulin resistance. Insulin resistance is likely to be the most important public health concern in many parts of the world in coming decades. This volume provides up-to-date reviews of these areas, providing the reader with a current perspective on issues in insulin resistance as they affect patients across the lifespan. The hope for Insulin Resistance: Childhood Precursors and Adult disease is that it will spur continued interest in the topic on the part of clinicians and researc

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Editorial Reviews

Doody's Review Service
Reviewer: Elizabeth Eames Littlejohn, M.D.(University of Chicago Pritzker School of Medicine)
Description: This is an up-to-date review of the advances in our understanding of the specific contributions of prenatal, childhood, and adolescent factors to the development of insulin resistance (IR). It also discusses issues of IR across the lifespan.
Purpose: The purpose is to present the epidemiology, including definitions of IR, updated discussion of the pathophysiology of IR, and treatments, as well as the specific contributions of exercise and medical therapy for weight loss, to those manifesting IR. The book meets these broad objectives as well as the more specific objectives of providing a clear chronological discussion of the evolution of the criteria for metabolic syndrome (MetS), of which IR is a component.
Audience: It is written for healthcare providers, both physicians and nurses, who encounter patients with IR and MetS in their practices. It would also be important for students. The authors are credible authorities, but are not the leaders of the field internationally.
Features: The book includes an excellent discussion of the progression and evolution of the MetS criteria and an objective discussion of the relevance of why each criterion was developed. The explanation of IR mechanisms is technical and difficult to read, particularly since it lacks diagrams. However, the discussions of both the consequences and treatment of IR are complete and up to date. The color plates are extraordinary, but poorly referenced in the book. The introductions in each chapter are repetitive.
Assessment: Overall, this book makes a very good attempt at establishing the factors that are relevant in the development of IR across the lifespan. These include influences from the fetal environment, through the neonatal, childhood, and adolescent periods into adulthood. The book could have addressed some aspects of prevention in the time leading up to the end result of IR. However, it contributes to the field as a first attempt at presenting childhood factors of importance in the development of an adult disease.
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Product Details

  • ISBN-13: 9781588298751
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 8/18/2008
  • Series: Contemporary Endocrinology Series
  • Edition description: 2008
  • Edition number: 1
  • Pages: 331
  • Product dimensions: 6.30 (w) x 9.10 (h) x 0.80 (d)

Table of Contents


The metabolic syndrome: definitions, controversies, and clinical utility. Lewis W Johnson MD, Ruth S Weinsk MD, PhD

Epidemiology of the Metabolic syndrome and related disorders in children and adolescents – Jennifer L Foltz MD, Stephen R Cook MD, MPH

Metabolic syndrome in children and adolescents worldwide – Orit Pinhas-Hamiel MD

Maternal-fetal contributors to the insulin resistance syndrome in youth – Dana Dabelea MD, PhD

Early childhood contributions to insulin resistance – David B Dunger MD, FRCP, FRCPCH, Burak Salgin, Ken K Ong MRCPCH PhD


Molecular Mechanisms of insulin resistance - Boris Draznin MD, PhD

Techniques used to assess insulin action – Michael J Pagliassotti PhD, Kyle T. Pfaffenbach MS, Tracy J. Horton

Adiposity is the enemy: body composition and insulin sensitivity – J Higgins PhD, William T Donahoo MD

Ectopic fat deposition: adiponectin and insulin resistance in obese adolescents – Anna MG Cali MD, Sonia Caprio MD

Mediators of insulin resistance - Rocio Periera MD, David Maahs MD

Insulin resistance and the pathogenesis of cardiovascular disease. – Ramzi Ajjan MRCP, MMed.Sci, PhD, Mark T Kearn FRCP, PhD, Peter T Grant FRCP, MD

Insulin Resistance and Cardiovascular disease: Cecilia C Low Wang MD

The liver and insulin resistance: the important convergence of endocrinology and hepatology – Charissa Y Chang, MD , Kerry Whitt MD, Zhenqi Liu MD, Stephen H Caldwell MD

Polycystic Ovarian Syndrome and metabolic syndrome: Marie-Helene. Pesant MD, Jean-Patrice BaillargeonMD


Effects of Exercise in Metabolic Syndrome and Diabetes: A Central Role for Insulin Sensitivity – Irene E Schauer MD, PhD, Judith.G. Regensteiner PhD, Jane EB. Reusch MD

Weight loss medications and the metabolic syndrome – Linda Buckley MD, Daniel Bessessen MD.

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