Insulin Resistance: Insulin Action and its Disturbances in Disease / Edition 1

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In this book, several leading investigators who have made seminal contributions to the field have written chapters covering the normal biology of insulin action, the pathophysiology of insulin resistance, the myriad clinical consequences of insulin resistance, and finally, current and future prospects for its treatment. The book therefore not only provides an up-to-date perspective of the subject from several of the leading thinkers in the field, but should also serve as a useful source of reference for students, researchers and clinicians.
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Editorial Reviews

From the Publisher
"The book is intended for specialists…however with the current interest in obesity and the threats it poses to the general public health, others will also find it of interest." (E-STREAMS, September 2006)

"...a major contribution to the increasing body of work...this book appears at an appropriate moment to educate and excite young investigators…" (New England Journal of Medicine, November 17, 2005)

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Product Details

  • ISBN-13: 9780470850084
  • Publisher: Wiley
  • Publication date: 2/6/2004
  • Edition number: 1
  • Pages: 616
  • Product dimensions: 6.89 (w) x 9.67 (h) x 1.41 (d)

Table of Contents

1 The insulin receptor and downstream signalling 1
2 Insulin-mediated regulation of glucose metabolism 63
3 Insulin action on lipid metabolism 87
4 The effect of insulin on protein metabolism 105
5 Genetically modified mouse models of insulin resistance 133
6 Insulin resistance in glucose disposal and production in man with specific reference to metabolic syndrome and type 2 diabetes 155
7 Central regulation of peripheral glucose metabolism 179
8 Relationship between fat distribution and insulin resistance 207
9 PPAR[gamma] and glucose homeostasis 237
10 Adipokines and insulin resistance 269
11 Dietary factors and insulin resistance 297
12 Physical activity and insulin resistance 317
13 Genetics of the metabolic syndrome 401
14 Insulin resistance and dyslipidaemia 451
15 Insulin resistance, hypertension and endothelial dysfunction 467
16 Insulin resistance and polycystic ovary syndrome 485
17 Syndromes of severe insulin resistance (SSIRs) 511
18 Therapeutic strategies for insulin resistance 535
19 Drug therapy for insulin resistance - a look at the future 561
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