Interrelationship Among Aging, Cancer and Differentiation: Proceedings of the Eighteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 29-May 2, 1985 / Edition 1

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Product Details

  • ISBN-13: 9789027721174
  • Publisher: Springer Netherlands
  • Publication date: 11/30/1985
  • Series: Jerusalem Symposia Series , #18
  • Edition description: 1985
  • Edition number: 1
  • Pages: 356
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

Interrelationships among Aging, Cancer and Differentiation.- Deceleration of Cancer Mortality Rates with Age and Time.- Clinical Aspects of Cancer in the Elderly.- Overview of the Pathobiology of Aging.- Regulators of Growth, Differentiation and the Reversal of Malignancy.- Transforming Genes of Human Malignancies.- Cancer Cells as Probes of Embryonic Development.- Alterations in Epidermal Differentiation in Skin Carcinogenesis.- Virus Transformation as a Function of Age, Differentiation and Hereditary Factors.- Negative Control of Viral and Cellular Enhancer Activity by the Products of the Immortalizing E1A Gene of Human Adenovirus-2.- Expression of two Murine Gene Families in Transformed Cells and Embryogenesis.- Methotrexate Resistance, Gene Amplification, and Somatic Cell Heterogeneity.- Macromolecular Correlates of Cellular Senescence and Cancer.- Dominance of in Vitro Senescence in Somatic Cell Hybridization and Biochemical Experiments.- Studies on Gene Structure and Function in Aging: Collagen Types I and II and the Albumin Genes.- Retrovirus-like Gene Families in Normal Cells : Potential for Affecting Cellular Gene Expression.- The Conformational Effects of UV Induced Damage on DNA.- DNA Supercoiling and Gene Expression.- Intermediates in Transcription Initiation and Propagation.- New Carbohydrate Binding Proteins (Lectins) in Human Cancer Cells and their Possible Role in Cell Differentiation and Metastasation.- Control of Gene Expression by Oligonucleoside Methylphosphonates.- Genetic Mechanisms in Tumor Progression, Heterogeneity, and Metastasis.- Genes, Fragile Sites, Chromosomal Translocations, and Cancer in Aging.- Comparison of Human and Rodent Cell Transformation by Known Chemical Carcinogens.- Critical Molecular Events and Gene Regulation in Carcinogenesis, Differentiation and Aging.- Monoclonal Antibodies Directed against Alkyl-Deoxynucleosides and Cell Type- and Differentiation Stage-Specific Cell Surface Determinants in the Study of Ethylnitrosourea-Induced Carcinogenesis in the Developing Rat Brain.- Structure and Biology of Scrapie Prions.- Diseases of Aging : Viral Genes and Perturbation of Differentiated Functions in Persistent Infection.- Ageing and Cancer. A Common Free Radical Mechanism—.- Cancer in the Elderly : Clinical and Biologic Considerations.- Cellular studies on the Interrelationship Among Cancer, Aging and Cellular Differentiation..
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