Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis

Overview

Complex molecular mechanisms involving microbiology and immunology define the host-pathogen relationship. These mechanisms can be the basis for new drugs and vaccine design. This book provides information on the molecular interactions between host cell organelles and pathogens, which have developed strategies to survive within infected cells. Chapters are grouped into five sections: I. Endocytosis and phagocytosis. Collectively, the chapters of this section review basic knowledge regarding intracellular ...

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Overview

Complex molecular mechanisms involving microbiology and immunology define the host-pathogen relationship. These mechanisms can be the basis for new drugs and vaccine design. This book provides information on the molecular interactions between host cell organelles and pathogens, which have developed strategies to survive within infected cells. Chapters are grouped into five sections: I. Endocytosis and phagocytosis. Collectively, the chapters of this section review basic knowledge regarding intracellular organelles are involved in membrane interactions with pathogen-containing vacuoles. II. Professional and non-professional phagocytes. Here the authors describe the major differences between the two host cell types, which can be infected by microorganisms. III. Maturation pathways of bacteria-containing vacuoles. Molecular interactions between vacuoles and intracellular organelles leading to the search of the Holy Grail, the replication niche, are described. IV. Host response. Host cells are able to react against intruders and eventually mount host responses. In these chapters the various types of host response mechanisms against intracellular intruders are reviewed. V. Co-evolution. In these final chapters, the question is addressed of whether knowledge of bacteria-host cell interactions will be acquired fast enough to find the necessary tools for controlling microorganism development. This comprehensive book appeals to scientists interested in cell biology, microbiology and immunology, as well as to clinically-oriented investigators concerned with infectious diseases.

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Product Details

  • ISBN-13: 9780306478338
  • Publisher: Springer US
  • Publication date: 1/31/1993
  • Series: Molecular Biology Intelligence Unit Series
  • Edition description: 2003
  • Edition number: 1
  • Pages: 324
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.75 (d)

Table of Contents

Preface
1 Membrane Traffic in the Endocytic Pathway 1
2 Lysosomes 16
3 Lipid Rafts and Host Cell-Pathogen Interactions 34
4 Endosome-Phagosome Interactions in Pathogenesis 51
5 Macrophages: Agents of Immunological Surveillance or Targets for Pathogens? 65
6 Intestinal Epithelial Cells: A Route of Entry for Entero-Invasive Pathogens 85
7 Life and Death of Brucella within Cells 99
8 Biogenesis of Salmonella-Containing Vacuoles in Eukaryotic Cells 130
9 Evasion of Phagosome Lysosome Fusion and Establishment of a Replicative Organelle by the Intracellular Pathogen Legionella pneumophila 142
10 Phagosome Biogenesis in Relation to Intracellular Survival Mechanisms of Mycobacteria 153
11 Molecular Mechanisms Regulating Membrane Traffic in Macrophages: Lessons from the Intracellular Pathogen Mycobacterium spp 170
12 Chlamydia 179
13 Host Cell Signaling Induced by the Pathogenic Neisseria Species 190
14 Against Gram-Negative Bacteria: The Lipopolysaccharide Case 204
15 Immune Recognition of the Mycobacterial Cell Wall 231
16 Antigen Presentation by MHC Class II Molecules 251
17 Bacteria-Induced Innate Immune Responses at Epithelial Linings 279
18 Pathogens and Hosts: Who Wins? 290
Index 295
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