Intractable Epilep Ain V97

Intractable Epilep Ain V97

by Blume, G. Bryan Young, Peter L. Carlen, Samuel Wiebe
     
 

ISBN-10: 0781758157

ISBN-13: 9780781758154

Pub. Date: 10/11/2005

Publisher: Wolters Kluwer Health

This volume brings together the latest advances in the understanding, diagnosis, and management of intractable epilepsies. Noted experts review cutting-edge research and its clinical implications, explore strategies for designing new drugs, and offer patient management guidelines for adults and children. Major sections identify the mechanisms and clinical features

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Overview

This volume brings together the latest advances in the understanding, diagnosis, and management of intractable epilepsies. Noted experts review cutting-edge research and its clinical implications, explore strategies for designing new drugs, and offer patient management guidelines for adults and children. Major sections identify the mechanisms and clinical features in each seizure type that distinguish controllable from intractable epilepsies. Chapters examine intensive care management of status epilepticus and factors determining short-term and long-term prognosis, including seizure type, etiology, and age of onset. Other patient management issues include differential diagnosis, predictors of intractability, neurophysiological and neuroimaging evaluation, and drug selection.

Product Details

ISBN-13:
9780781758154
Publisher:
Wolters Kluwer Health
Publication date:
10/11/2005
Series:
Advances in Neurology
Pages:
624
Product dimensions:
7.00(w) x 10.00(h) x 1.31(d)

Related Subjects

Table of Contents

Sect. 1Epidemiology and cost
1Burden of intractable epilepsy1
2Defining intractable epilepsy5
3Outcome measures in intractable epilepsy11
Sect. 2Focal epileptic seizures : temporal/limbic
4Focal seizures : intractability and semiology17
5The syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis : clinical features and differential diagnosis27
6Clinical aspects of temporal/limbic epilepsy and their relationships to intractability39
7Clinical electrophysiology factors indicative of intractability in patients with temporal lobe epilepsy45
8Epilepsy-based changes in hippocampal excitability : causes and effects63
9Selective degeneration and synaptic reorganization of hippocampal interneurons in a chronic model of temporal lobe epilepsy69
10Parahippocampal networks, intractability, and the chronic epilepsy of kindling77
11Novel mechanisms underlying drug resistance in temporal lobe epilepsy85
12Failure of surgery for temporal lobe epilepsy : a review of selected aspects97
Sect. 3Focal epileptic seizures : neocortical
13Neocortical epilepsy : aspects distinguishing intractable from benign neocortical epilepsies105
14Intractable epilepsies of the neocortex : basic mechanisms117
15Simultaneous electroencephalogram-functional magnetic resonance imaging in neocortical epilepsies129
Sect. 4Generalized epileptic seizures
16What intractability information is there in the type of generalized seizure?141
17Neuronal substrates of spike-wave seizures and hypsarrhythmia in corticothalamic systems149
18Novel strategies for the development of animal models of refractory epilepsy155
19Participation of cortical glial cells to the genesis of spike-wave seizures173
Sect. 5Intractable epilepsy in the intensive care unit
20Status epilepticus and refractory status epilepticus : introductory and summary statements183
21Basic mechanisms in status epilepticus : role of calcium in neuronal injury and the induction of epileptogenesis187
22Epidemiology and clinical presentation of status epilepticus199
23Status epilepticus and brain damage : pathology and pathophysiology217
24Nonconvulsive seizures and electroencephalogram monitoring in the intensive care unit221
25Status epilepticus in pediatric practice : neonate to adolescent229
26Current approach to the diagnosis and treatment of refractory status epilepticus245
Sect. 6Neuroimaging
27Magnetic resonance imaging sequences for detection of lesions in refractory epilepsy255
28Magnetic resonance imaging in intractable epilepsy : focus on structural image analysis273
29High-resolution magnetic resonance imaging (MRI), surface coil MRI, and magnetoencephalography279
30Magnetic resonance spectroscopic techniques for localizing epileptogenic zones in refractory partial epilepsy285
Sect. 7Consequences : is intractable epilepsy progressive?
31Animal models of epilepsy and progressive effects of seizures293
32Mechanisms that might underlie progression of the epilepsies and how to potentially alter them305
33Clinical evidence that epilepsy is not a progressive disorder with special emphasis on epilepsy syndromes that do not progress315
34Clinical evidence that epilepsy is a progressive disorder with special emphasis on epilepsy syndromes that do progress323
Sect. 8Comorbidity
35Psychosocial comorbidity in epilepsy333
36Behavioral comorbidities : attention deficit hyperactivity disorder - human and animal studies339
37Medical comorbidity in intractable epilepsy345
38Intractable epilepsy, hormonal and reproductive problems : human and animal studies351
Sect. 9Neuropsychological profiles
39Neuropsychological profiles357
Sect. 10The social impacts of intractable epilepsy
40Intractable epilepsy and patterns of psychiatric comorbidity367
41Psychological treatment in intractable epilepsy : approaches, evidence, and future directions375
Sect. 11Genetics
42Monogenic epilepsies in humans : molecular mechanisms and relevance for the study of intractable epilepsy381
43Polygenic epilepsy389
44On the road to tractability : the current biochemical understanding of progressive myoclonus epilepsies399
Sect. 12Therapy : development of new antiepileptic drugs
45Major targets and mechanisms of antiepileptic drugs and major reasons for failure417
46Designing future drugs for the treatment of intractable epilepsy429
Sect. 13Principles of management of intractable epilepsy : children
47The definition and prediction of intractable epilepsy in children435
48Diseases and syndromes associated with intractable epilepsy443
49Management of intractable epilepsy in infancy and childhood463
Sect. 14Principles of management of intractable epilepsy : adults
50The spectrum of intractable epilepsy : a proposed scale493
51Differential diagnostic considerations in patients with intractable epilepsy497
52Investigations : how the data affect management517
53Medical management of intractable epilepsy527
Sect. 15Surgery
54Assessment of patients with intractable epilepsy for surgery537
55Palliative surgery for intractable epilepsy549
56Evaluating surgery effectiveness557
57Deep brain stimulation and cortical stimulation in the treatment of epilepsy563

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