Intractable Epilep Ain V97

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This volume brings together the latest advances in the understanding, diagnosis, and management of intractable epilepsies. Noted experts review cutting-edge research and its clinical implications, explore strategies for designing new drugs, and offer patient management guidelines for adults and children.

Major sections identify the mechanisms and clinical features in each seizure type that distinguish controllable from intractable epilepsies. Chapters examine intensive care management of status epilepticus and factors determining short-term and long-term prognosis, including seizure type, etiology, and age of onset. Other patient management issues include differential diagnosis, predictors of intractability, neurophysiological and neuroimaging evaluation, and drug selection.

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Product Details

  • ISBN-13: 9780781758154
  • Publisher: Wolters Kluwer Health
  • Publication date: 10/11/2005
  • Series: Advances in Neurology
  • Pages: 624
  • Product dimensions: 7.00 (w) x 10.00 (h) x 1.31 (d)

Table of Contents

Sect. 1 Epidemiology and cost
1 Burden of intractable epilepsy 1
2 Defining intractable epilepsy 5
3 Outcome measures in intractable epilepsy 11
Sect. 2 Focal epileptic seizures : temporal/limbic
4 Focal seizures : intractability and semiology 17
5 The syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis : clinical features and differential diagnosis 27
6 Clinical aspects of temporal/limbic epilepsy and their relationships to intractability 39
7 Clinical electrophysiology factors indicative of intractability in patients with temporal lobe epilepsy 45
8 Epilepsy-based changes in hippocampal excitability : causes and effects 63
9 Selective degeneration and synaptic reorganization of hippocampal interneurons in a chronic model of temporal lobe epilepsy 69
10 Parahippocampal networks, intractability, and the chronic epilepsy of kindling 77
11 Novel mechanisms underlying drug resistance in temporal lobe epilepsy 85
12 Failure of surgery for temporal lobe epilepsy : a review of selected aspects 97
Sect. 3 Focal epileptic seizures : neocortical
13 Neocortical epilepsy : aspects distinguishing intractable from benign neocortical epilepsies 105
14 Intractable epilepsies of the neocortex : basic mechanisms 117
15 Simultaneous electroencephalogram-functional magnetic resonance imaging in neocortical epilepsies 129
Sect. 4 Generalized epileptic seizures
16 What intractability information is there in the type of generalized seizure? 141
17 Neuronal substrates of spike-wave seizures and hypsarrhythmia in corticothalamic systems 149
18 Novel strategies for the development of animal models of refractory epilepsy 155
19 Participation of cortical glial cells to the genesis of spike-wave seizures 173
Sect. 5 Intractable epilepsy in the intensive care unit
20 Status epilepticus and refractory status epilepticus : introductory and summary statements 183
21 Basic mechanisms in status epilepticus : role of calcium in neuronal injury and the induction of epileptogenesis 187
22 Epidemiology and clinical presentation of status epilepticus 199
23 Status epilepticus and brain damage : pathology and pathophysiology 217
24 Nonconvulsive seizures and electroencephalogram monitoring in the intensive care unit 221
25 Status epilepticus in pediatric practice : neonate to adolescent 229
26 Current approach to the diagnosis and treatment of refractory status epilepticus 245
Sect. 6 Neuroimaging
27 Magnetic resonance imaging sequences for detection of lesions in refractory epilepsy 255
28 Magnetic resonance imaging in intractable epilepsy : focus on structural image analysis 273
29 High-resolution magnetic resonance imaging (MRI), surface coil MRI, and magnetoencephalography 279
30 Magnetic resonance spectroscopic techniques for localizing epileptogenic zones in refractory partial epilepsy 285
Sect. 7 Consequences : is intractable epilepsy progressive?
31 Animal models of epilepsy and progressive effects of seizures 293
32 Mechanisms that might underlie progression of the epilepsies and how to potentially alter them 305
33 Clinical evidence that epilepsy is not a progressive disorder with special emphasis on epilepsy syndromes that do not progress 315
34 Clinical evidence that epilepsy is a progressive disorder with special emphasis on epilepsy syndromes that do progress 323
Sect. 8 Comorbidity
35 Psychosocial comorbidity in epilepsy 333
36 Behavioral comorbidities : attention deficit hyperactivity disorder - human and animal studies 339
37 Medical comorbidity in intractable epilepsy 345
38 Intractable epilepsy, hormonal and reproductive problems : human and animal studies 351
Sect. 9 Neuropsychological profiles
39 Neuropsychological profiles 357
Sect. 10 The social impacts of intractable epilepsy
40 Intractable epilepsy and patterns of psychiatric comorbidity 367
41 Psychological treatment in intractable epilepsy : approaches, evidence, and future directions 375
Sect. 11 Genetics
42 Monogenic epilepsies in humans : molecular mechanisms and relevance for the study of intractable epilepsy 381
43 Polygenic epilepsy 389
44 On the road to tractability : the current biochemical understanding of progressive myoclonus epilepsies 399
Sect. 12 Therapy : development of new antiepileptic drugs
45 Major targets and mechanisms of antiepileptic drugs and major reasons for failure 417
46 Designing future drugs for the treatment of intractable epilepsy 429
Sect. 13 Principles of management of intractable epilepsy : children
47 The definition and prediction of intractable epilepsy in children 435
48 Diseases and syndromes associated with intractable epilepsy 443
49 Management of intractable epilepsy in infancy and childhood 463
Sect. 14 Principles of management of intractable epilepsy : adults
50 The spectrum of intractable epilepsy : a proposed scale 493
51 Differential diagnostic considerations in patients with intractable epilepsy 497
52 Investigations : how the data affect management 517
53 Medical management of intractable epilepsy 527
Sect. 15 Surgery
54 Assessment of patients with intractable epilepsy for surgery 537
55 Palliative surgery for intractable epilepsy 549
56 Evaluating surgery effectiveness 557
57 Deep brain stimulation and cortical stimulation in the treatment of epilepsy 563
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