Intraoperative Irradiation: Techniques and Results / Edition 2

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Overview

The rationale for using intraoperative irradiation (IORT) is based on the realization that tolerable doses of eternal beam radiation are often insufficient to achieve control of locally advanced malignancies. In these instances, the IORT component of treatment becomes the optimal conformal technique of irradiation, since dose-limiting organs or structures can either be surgically displaced or protected by placement of lead shielding.
This fully revised and expanded second edition is of interest to those with intraoperative electron (IOERT) capabilities, high-dose-rate brachytherapy (HDR-IORT) capabilities, or both. Techniques, indications, and results are discussed by disease site. Each chapter is dual authored by a radiation oncologist and a surgeon, giving a balanced presentation of clinical scenarios. Issues of basic science and physics are also covered, and a notable chapter on normal tissue tolerance is included.
Intraoperative Irradiation: Techniques and Results, Second Edition is a superb compilation, providing essential cutting-edge knowledge. It is a foundation for physicians as IORT develops and becomes more widely available.

The book contains black-and-white illustrations.

An expert team of clinicians have compiled this comprehensive textbook on intraoperative irradiation for those utilizing either intraoperative electrons or brachytherapy. Issues of basic science and physics are covered in addition to techniques, indications, and results by disease states. Leading authorities discuss the use of these techniques on specific organs or systems including the lungs, pancreas, bones, head and neck, and gastric system. Specific chapters are included for the use of intraoperative irradiation in pediatric surgery. Three world leaders in intraoperative electron irradiation and a prominent brachytherapy expert have created this important text for radiation oncologists, surgeons, physicists, and medical oncologists using various types of intraoperative irradiation.

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Editorial Reviews

James G. Douglas
This comprehensive textbook examines the modality of intraoperative radiotherapy (IORT). It is edited and written by the acknowledged international experts in this field. It is written as an in depth exposition on intraoperative irradiation (IORT) and addresses the basic science concepts of IORT as well as techniques, indications, and results by disease sites. It is primarily directed to radiation oncologists and medical physicists, and secondarily to others involved in cancer care and intraoperative radiotherapy procedures, including medical oncologists, surgical oncologists, radiotherapists, anesthesiologists, and nursing personnel. The editors begin this work with an in depth examination of the rationale for the use of IORT and an historical overview of the development of the technique. The recommended doses currently being used for IORT as a single modality or as a boost after conventional external beam radiotherapy are explored as well. Two techniques of IORT, electron beam therapy (IOERT) and high-dose-rate brachytherapy (HDR-IORT) are compared and contrasted. An excellent physics section reviews the radiobiologic rationale, as well as the physical aspects (description of linear accelerators, HDR apparatus, dosimetry, etc.) of IOERT and HDR-IORT. Normal tissue tolerance to IORT, with an emphasis on experimental animal data follows in the ensuing chapters. Clinical results of various modalities including IORT for specific disease sites are reviewed in depth. These chapters are very well written in a concise manner and include excellent bibliographies. A final section on future possibilities for IORT concludes this textbook. The figures, photographs, and diagrams areappropriately included and of good quality. This is a comprehensive textbook devoted exclusively to a discussion of IORT, a modality yet to find its ultimate place in radiotherapy. The greatest gains have perhaps been seen in GI malignancies, although the results described for other disease sites are provocative. The use of electron beam IORT is generally restricted to large centers; however, the development of HDR-IORT may allow many smaller centers to use this technique in their cancer treatment armamentarium. Some of the redundancies found in several chapters could have been eliminated by more stringent editing. Otherwise, this is a thorough, well written, informative textbook which would be a welcome addition to the radiation and surgical oncologist's reference library.
Booknews
Reviews the techniques, indications, and results of using intraoperative electrons (IORT) and high-dose-rate brachytherapy (HDR- IORT). The 29 contributions are arranged into five major sections<-- >general rationale and historical perspective, methods and techniques of treatments, normal tissue/organ tolerance to IORT, results of IORT with or without EBRT by disease site, and conclusions and future possibilities. The 18 disease site chapters cover every part of the body for which the potential merit of IORT has been demonstrated, and discuss data on disease control, survival, and treatment tolerance. Intended for surgeons, radiation oncologists, physicists, and medical oncologists. Annotation c. by Book News, Inc., Portland, Or.
Doody's Review Service
Reviewer: James G Douglas, MD, MS (Memorial Hospital of Sweetwater County)
Description: This comprehensive textbook examines the modality of intraoperative radiotherapy (IORT). It is edited and written by the acknowledged international experts in this field.
Purpose: It is written as an in depth exposition on intraoperative irradiation (IORT) and addresses the basic science concepts of IORT as well as techniques, indications, and results by disease sites.
Audience: It is primarily directed to radiation oncologists and medical physicists, and secondarily to others involved in cancer care and intraoperative radiotherapy procedures, including medical oncologists, surgical oncologists, radiotherapists, anesthesiologists, and nursing personnel.
Features: The editors begin this work with an in depth examination of the rationale for the use of IORT and an historical overview of the development of the technique. The recommended doses currently being used for IORT as a single modality or as a boost after conventional external beam radiotherapy are explored as well. Two techniques of IORT, electron beam therapy (IOERT) and high-dose-rate brachytherapy (HDR-IORT) are compared and contrasted. An excellent physics section reviews the radiobiologic rationale, as well as the physical aspects (description of linear accelerators, HDR apparatus, dosimetry, etc.) of IOERT and HDR-IORT. Normal tissue tolerance to IORT, with an emphasis on experimental animal data follows in the ensuing chapters. Clinical results of various modalities including IORT for specific disease sites are reviewed in depth. These chapters are very well written in a concise manner and include excellent bibliographies. A final section on future possibilities for IORT concludes this textbook. The figures, photographs, and diagrams are appropriately included and of good quality.
Assessment: This is a comprehensive textbook devoted exclusively to a discussion of IORT, a modality yet to find its ultimate place in radiotherapy. The greatest gains have perhaps been seen in GI malignancies, although the results described for other disease sites are provocative. The use of electron beam IORT is generally restricted to large centers; however, the development of HDR-IORT may allow many smaller centers to use this technique in their cancer treatment armamentarium. Some of the redundancies found in several chapters could have been eliminated by more stringent editing. Otherwise, this is a thorough, well written, informative textbook which would be a welcome addition to the radiation and surgical oncologist's reference library.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781617790140
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 5/1/2011
  • Series: Current Clinical Oncology Series
  • Edition description: 2nd ed. 2011
  • Edition number: 2
  • Pages: 530
  • Product dimensions: 7.20 (w) x 10.20 (h) x 1.60 (d)

Table of Contents

Part I. General Rationale and Historical Perspective
Ch 1 – Rationale and Historical Perspective of Intraoperative Irradiation
Leonard L Gunderson, Felipe A Calvo, Christopher G Willett, and Louis B Harrison
Ch 2 – Radiobiology of Large Dose per Fraction Irradiation
Paul Okunieff, Srinath Sundararaman, Su Metcalfe, and Yuhchyau Chen
Part II. Methods and Techniques of Treatment
Ch 3 – Intraoperative Electron-Beam Irradiation (IOERT): Physics and Techniques
Peter Biggs, Christopher G. Willett, Harm Rutten, Mario Ciocca, Leonard L. Gunderson, and Felipe A. Calvo
Ch 4 – HDR-IORT: Physics and Techniques
Eli E Furhang, Jussi K Sillanpaa, Kenneth Hu, and Louis B Harrison
Ch 5 – Electronic Brachytherapy/Low KV IORT: Physics and Techniques
Uta Kraus-Tiefenbacher, Peter Biggs, Jayant Vaidya, and Dario Francescatti
Ch 6 – IORT with Electron Beam, High Dose Rate Brachytherapy or Low-KV/Electronic Brachytherapy:
Methodological Comparisons
Subir Nag, Christopher G. Willett, Leonard L. Gunderson, Louis B. Harrison, Felipe A. Calvo, and Peter Biggs
Part III. Normal Tissue Tolerance – IORT
Ch 7 – Normal Tissue Tolerance to IOERT, EBRT or Both: Animal Studies and Clinical
Zeljko Vujaskovic, Christopher G Willett, Joel E Tepper, Timothy J Kinsella, and Leonard L Gunderson
Ch 8 – Central Nervous System Tumors
David Ortiz de Urbina, Patrick Schueller, Normann Willich, Kintomo Takakura, Osami Kubo, and Felipe A. Calvo
Ch 9 – Head and Neck Cancer
Kenneth S. Hu, Sue Yom, Michael J. Kaplan, Louis B. Harrison, and Rafael Martinez-Monge
Ch 10 – Breast Cancer
Felix Sedlmayer, Jean-Bernard DuBois, Roland Reitsamer, Gerd Fastner, David Olilla, and Roberto Orecchia
Ch 11 – Lung CancerJavier Aristu, Felipe A. Calvo, Marta Moreno, Rafael Martínez, Jesu's Herreros, Raquel Ciérvide, Jean Bernard Dubois, and Scott Fisher
Ch 12 – Gastric Cancer
Rafael Martinez-Monge, Miren Gaztañaga, Javier Álvarez-Cienfuegos, Robert C. Miller, and Felipe A. Calvo
Ch 13 – Pancreas Cancer
Robert C. Miller, Vincenzo Valentini, Adyr Moss, Giuseppe R D’Agostino, Matthew D. Callister, Theodore Hong, Christopher G. Willett, and Leonard L. Gunderson
Ch 14 – Bile Duct and Gallbladder Cancer
Takeshi Todoroki, Gernot M. Kaiser, Wolfgang Sauerwein, and Leonard L. Gunderson
Ch 15 – Primary Colorectal Cancer
Nils D. Arvold, Theodore S. Hong, Christopher G. Willett, Paul C. Shellito, Michael G. Haddock, Harm Rutten, Vincenzo Valentini, Brian Czito, and Leonard L. Gunderson
Ch 16 – Recurrent Colorectal Cancer
Michael G. Haddock, Heidi Nelson, Vincenzo Valentini, Leonard L. Gunderson, Christopher G. Willett, Harm Rutten, Felipe A Calvo, Lou Harrison, Warren Enker, and JL Garcia-Sabrido
Ch 17 – Retroperitoneal Sarcomas
Brian Czito, John Donohue, Christopher Willett, Doug Tyler, Ivy Petersen, Robert Krempien, Kenneth Hu, Felipe Calvo, Matthew Callister, Kaled Alektiar, Michael Eble,
and Ana Alvarez
Ch 18 – Extremity and Trunk Soft Tissue Sarcomas
Ivy A Petersen, Robert Krempien, Christopher Beauchamp, Michael Eble, Felipe Calvo, Ignacio Azinovic, Matthew A Callister, and Ana Alvarez
Ch 19 – Bone Sarcomas
Felipe A. Calvo, Luis Sierrasesumaga, Ana Patiño, Carmen González, Manuel González, Carlos Ferrer, Norman Willich, and José Cañadell
Ch 20 – Gynecologic Malignancies
Kaled M. Alektiar, Michael G. Haddock, Dennis Chi, Felipe A. Calvo, and Ivy A. Petersen
Ch 21 – Genitourinary Cancer
Marco Krengli, Felipe A. Calvo, Carlo Terrone, Michael Haddock, Jean-Michel Hannoun-Levi, Juliette Thariat, Jean-Pierre Gerard, and Roberto Orecchia
Ch 22 – Pediatric MalignanciesNadia N. Issa Laack, Paula J. Schomberg, Suzanne Wolden, and Jesus Vazquez
Part V. Conclusions and Future Possibilities
Ch 23 – Conclusions and Future Possibilities – IORT
Leonard L Gunderson, Christopher G Willett, Felipe A Calvo, and Louis B Harrison

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