Introduction to Biocatalysis Using Enzymes and Microorganisms

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This is an introductory text intended to give the non-specialist a comprehensive insight into the science of biotransformations. The book traces the history of biotransformations, clearly spells out the pros and cons of conducting enzyme-mediated versus whole-cell bioconversions, and gives a variety of examples wherein the bio-reaction is a key element in a reaction sequence leading from the cheap starting materials to valuable end-products (such as pharmaceuticals and agrochemicals, fragrances and flavours). Biotransformations involving the hydrolysis of esters, amides, and nitriles, the synthesis of esters and amides, reduction and oxidation reactions, and carbon-carbon bond-forming systems are discussed. The book finishes with a discussion of some industrially important large-scale bioconversions.

The application of biocatalysis to the manufacture of fine chemicals/the interrelationships between enzymes & cells/etc

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Editorial Reviews

From the Publisher
"...I would recommend this as a good book to initiate researchers in the use of enzymes for obtaining organic compounds." Josep J. Centelles, The Biochemist

"...well written and well organized....A good introductory work that will be useful for scientists in many different fields." Choice

"...a comprehensive summary of numerous biological conversions including pharmaceuticals and agrochemicals, fragrances and flavors....well written and endowed with tables, figures and could be a good textbook or backbone for a course in the developing field of biotransformations. This book deserves a place in the library of graduate and post-graduate levels as a valuable source of information on this vital area." Jean-Luc Berger, CSM Newsletter

"...a flexible and well-written book that is suitable as a supplement to existing course materials in biochemistry or organic chemistry....should also be valuable as the core of a free-standing course for undergraduates, and as an entry to the working chemist or biologist interested in exploring this area for the first time." Manuel A. Navia, Quarterly Review of Biology

"This book is clearly written and can be read from cover to cover in less than a day. It is suitable as supplementary reading for an upper-level undergraduate or beginning graduate class in methods of organic synthesis. It would also be useful as background reading for students pursuing independent study projects involving biocatalysis." Douglas C. Cameron, Journal of the American Chemical Society

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Product Details

  • ISBN-13: 9780521430708
  • Publisher: Cambridge University Press
  • Publication date: 3/28/2003
  • Pages: 208
  • Product dimensions: 6.20 (w) x 9.10 (h) x 0.70 (d)

Table of Contents

1 An historical introduction to biocatalysis using enzymes and micro-organisms 1
2 The interrelationships between enzymes and cells, with particular reference to whole-cell biotransformations using bacteria and fungi 34
3 Useful intermediates and end-products obtained from whole-cell
enzyme-catalysed hydrolysis and esterification reactions 80
4 Useful intermediates and end-products obtained from biocatalysed oxidation and reduction reactions 98
5 Useful intermediates and end-products obtained from biocatalysed carbon-carbon, carbon-oxygen, carbon-nitrogen and carbon-chalcogen bond-forming reactions 118
6 The application of biocatalysis to the manufacture of fine chemicals 140
Index 188
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