Introduction to Enzyme and Coenzyme Chemistry / Edition 3

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Enzyme catalysis is a topic of fundamental importance in organic, bio-organic and medicinal chemistry. This new edition of a very popular textbook provides a concise introduction to the underlying principles and mechanisms of enzyme and coenzyme action from a chemical perspective.

Whilst retaining the overall structure of the first edition – preliminary chapters describe the basic principles of enzyme structure and catalysis moving through to detailed discussions of the major classes of enzyme processes in the later chapters – the book has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action. A major feature of the second edition is the inclusion of two-colour figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. Problems, with outline answers, at the end of each chapter give the student the chance to the check their understanding of the material.

As a concise but comprehensive account, Introduction to Enzyme and Coenzyme Chemistry will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry.

Tim Bugg is professor of biological chemistry in the Department of Chemistry, University of Warwick, UK.

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Editorial Reviews

Doody's Review Service
Reviewer: Gene A. Homandberg, PhD (Rush Medical College of Rush University)
Description: This book is intended to be an introduction to organic chemical descriptions of the major types of enzyme mechanisms. It begins with chapters on enzymes as proteins, enzyme catalysis, and study methods and continues with discussion of the six major types of enzyme mechanisms. The last chapter discusses nonenzymatic catalysis, as mediated by catalytic RNA and catalytic antibodies.
Purpose: This book is an attempt to present the major types of mechanisms together and to emphasize the chemical concepts. This is a worthwhile purpose for organic chemistry students, although there are many enzyme and general biochemistry books that do present mechanisms in sufficient detail and also discuss and more completely illustrate the role of protein structure. Because of this emphasis, this book would be useful to emphasize the features and relevance of biologic catalysts in an organic chemistry course.
Audience: The audience is intended to be primarily biochemists, and especially students; however, the book would also be suitable for organic chemists or instructors wishing to expand their knowledge or explain the relevance of protein catalysts.
Features: This book has an attractive, easy to read format and features numerous illustrations, problem sets and suggested additional reading throughout.
Assessment: This book would be a worthwhile addition to the library of biochemistry students or instructors, because it does comprehensively present the major types of mechanisms in an easy-to-read and understand style. Although there are many other excellent enzyme books with a different emphasis, this book would still be quite useful.
From the Publisher
"[T]he well-chosen topics provide a highly readable, coherent introduction to enzyme chemistry."
Journal of Enzyme Inhibition and Medicinal Chemistry

"The first edition of this book was excellent and this new edition consolidates ‘Bugg’ as the pre-eminent textbook on the bioorganic aspects of chemical biology."
Chemistry World

"[T]urns this book into an outstanding choice for those that want to be inside the fabulous world of enzymes."
Physical Science Education Reviews

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Product Details

  • ISBN-13: 9781119995944
  • Publisher: Wiley
  • Publication date: 8/21/2012
  • Edition description: New Edition
  • Edition number: 3
  • Pages: 296
  • Sales rank: 1,028,074
  • Product dimensions: 6.60 (w) x 9.50 (h) x 0.80 (d)

Meet the Author

Tim Bugg is Professor of Biological Chemistry in the Department of Chemistry, University of Warwick, UK.

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Table of Contents

Preface; Representation of Protein Three-Dimensional Structures; From jack beans to designer genes; All enzymes are proteins; Enzymes are wonderful catalysts; Methods for studying enzymatic reactions; Hydrolytic and group transfer reactions; Enzymatic redox chemistry; Enzymatic carbon-carbon bond formation; Enzymatic additional/elimanation reactions; Enzymatic transformations of amino acids; Isomerases; Radicals in enzyme catalysis; Non-enzymatic biological catalysis; Appendices; Index

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