An Introduction to Forensic Genetics / Edition 2by William Goodwin, Adrian Linacre, Sibte Hadi
An Introduction to Forensic Genetics, 2nd Editionis a revised edition of this comprehensive and popular introduction to the fast moving area of Forensic Genetics. The book begins with the key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Now illustrated in full colour throughout, this/b>/sup>… See more details below
An Introduction to Forensic Genetics, 2nd Editionis a revised edition of this comprehensive and popular introduction to the fast moving area of Forensic Genetics. The book begins with the key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Now illustrated in full colour throughout, this accessible textbook includes references to relevant casework. With information on the full process of DNA evidence from collection at the scene of a crime to presentation in a legal context, providing a complete overview of the field.
A new chapter looking at non-human forensic genetics, including identification of bacteria and viruses, animals and plants is also included.
- Now with full colour illustrations throughout
- New companion website at www.wiley.com/go/forensic2e
- Greater coverage of kinship problems
- Accessible introduction to forensic genetics, from the collection of evidence to the presentation of evidence in a legal context.
Table of Contents
1 Introduction to forensic genetics.
A brief history of forensic genetics.
2 DNA structure and the genome.
Organization of DNA into chromosomes.
The structure of the human genome.
Genetic diversity of modern humans.
The genome and forensic genetics.
Single nucleotide polymorphisms.
3 Biological material - collection, characterization and storage.
Sources of biological evidence.
Collection and handling of material at the crime scene.
Identification and characterization of biological evidence.
Sexual and physical assault.
Storage of biological material.
4 DNA extraction and quantification.
DNA extraction from challenging samples.
Quantification of DNA.
DNA IQTM system.
5-The polymerase chain reaction.
The evolution of PCR-based profiling in forensic genetics.
DNA replication - the basis of the PCR.
The components of PCR.
The PCR process.
Sensitivity and contamination.
The PCR laboratory.
6 The analysis of short tandem repeats.
Structure of STR loci.
The development of STR multiplexes.
Detection of STR polymorphisms.
Interpretation of STR profiles.
7-Assessment of STR profiles.
Split peaks (+/- A).
Low copy number DNA.
8 Statistical interpretation of STR profiles.
Deviation from the Hardy-Weinberg equilibrium.
Statistical tests to determine deviation from the Hardy-Weinberg equilibrium.
Estimating the frequencies of STR profiles.
Corrections to allele frequency databases.
Which population frequency database should be used?
9 The evaluation and presentation of DNA evidence.
Hierarchies of propositions.
Comparison of three approaches.
10 Databases of DNA profiles.
The UK national DNA Database.
Useful web sites.
11 Kinship testing.
Identification of human remains.
12 Single nucleotide polymorphisms.
SNPs - occurrence and structure.
Detection of SNPs.
SNP detection for forensic applications.
Forensic applications of SNPs.
SNPs compared to STR loci.
13 Lineage markers.
Applications of mtDNA profiling.
The Y chromosome.
Forensic applications of Y chromosome polymorphisms.
Useful web sites.
Appendix 1 Forensic parameters.
Appendix 2 Useful web links.
and post it to your social network
Most Helpful Customer Reviews
See all customer reviews >