An Introduction to Forensic Genetics / Edition 2by William Goodwin, Adrian Linacre, Sibte Hadi
Pub. Date: 02/08/2011
This is a completely revised edition of a comprehensive and popular introduction to the fast moving area of Forensic Genetics. The text begins with key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Now illustrated in full colour throughout, this accessible textbook includes numerous references to
This is a completely revised edition of a comprehensive and popular introduction to the fast moving area of Forensic Genetics. The text begins with key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Now illustrated in full colour throughout, this accessible textbook includes numerous references to relevant casework. With information on the full process of DNA evidence from collection at the scene of a crime to presentation in a legal context this book provides a complete overview of the field.
- Greater in-depth coverage of kinship problems now covered in two separate chapters: one dealing with relationships between living individuals and the other covering identification of human remains.
- New chapter on non-human forensic genetics, including identification of bacteria and viruses, animals and plants.
- Self assessment questions to aid student understanding throughout the text.
- Now with full colour illustrations throughout
- New companion website
- Accessible introduction to forensic genetics, from the collection of evidence to the presentation of evidence in a legal context.
Included in the Forensic Science Society 'Essentials in Forensic Science' book series. This edition is to be included in the Forensic Science Society 'Essentials of Forensic Science' book series aimed at advanced level undergraduates and new practitioners to the field.
Table of Contents
1 Introduction to forensic genetics.
A brief history of forensic genetics.
2 DNA structure and the genome.
Organization of DNA into chromosomes.
The structure of the human genome.
Genetic diversity of modern humans.
The genome and forensic genetics.
Single nucleotide polymorphisms.
3 Biological material - collection, characterization and storage.
Sources of biological evidence.
Collection and handling of material at the crime scene.
Identification and characterization of biological evidence.
Sexual and physical assault.
Storage of biological material.
4 DNA extraction and quantification.
DNA extraction from challenging samples.
Quantification of DNA.
DNA IQTM system.
5-The polymerase chain reaction.
The evolution of PCR-based profiling in forensic genetics.
DNA replication - the basis of the PCR.
The components of PCR.
The PCR process.
Sensitivity and contamination.
The PCR laboratory.
6 The analysis of short tandem repeats.
Structure of STR loci.
The development of STR multiplexes.
Detection of STR polymorphisms.
Interpretation of STR profiles.
7-Assessment of STR profiles.
Split peaks (+/- A).
Low copy number DNA.
8 Statistical interpretation of STR profiles.
Deviation from the Hardy-Weinberg equilibrium.
Statistical tests to determine deviation from the Hardy-Weinberg equilibrium.
Estimating the frequencies of STR profiles.
Corrections to allele frequency databases.
Which population frequency database should be used?
9 The evaluation and presentation of DNA evidence.
Hierarchies of propositions.
Comparison of three approaches.
10 Databases of DNA profiles.
The UK national DNA Database.
Useful web sites.
11 Kinship testing.
Identification of human remains.
12 Single nucleotide polymorphisms.
SNPs - occurrence and structure.
Detection of SNPs.
SNP detection for forensic applications.
Forensic applications of SNPs.
SNPs compared to STR loci.
13 Lineage markers.
Applications of mtDNA profiling.
The Y chromosome.
Forensic applications of Y chromosome polymorphisms.
Useful web sites.
Appendix 1 Forensic parameters.
Appendix 2 Useful web links.
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