Introduction to Functional Magnetic Resonance Imaging CD-ROM: Principles and Techniques

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An Introduction to Functional Magnetic Resonance Imaging is an invaluable introduction to how fMRI works, from basic principles and underlying physics and physiology, to newer techniques such as arterial spin labeling and diffusion tensor imaging. The supplementary CD-ROM contains all the figures from the book as PowerPoint files, together with movies of cross-sectional anatomical MR images and a library of all the MR images used in the movies as individual Tiff files. As a resource for teachers and researchers, this combination of text and dual platform CD is unsurpassed.

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Editorial Reviews

From The Critics
Reviewer: Bernard D. Coombs, MB, ChB, PhD (University of Colorado Health Sciences Center)
Description: This book presents the physical, and in lesser detail the physiologic, basis of functional magnetic resonance imaging (fMRI). An overview of underlying physical processes and of the major fMRI techniques is presented in a unified style by a single author.
Purpose: Functional MRI is a rapidly developing field that combines many disciplines into a new field. The purpose of this book is to introduce the underlying physics and how it is applied to detect brain metabolic activity. There is a role for a treatment of fMRI techniques that is accessible and conceptual, but at the same time also provides enough detail to be materially useful to a researcher. Rather than focus heavily on the main basic technique for fMRI studies currently used (BOLD imaging), the author attempts to provide a broader perspective, anticipating future developments. These objectives seem well met.
Audience: The book is intended for graduate students in neuroscience. Enough detail has been included to also make the book useful to neuroscientists actively using fMRI, or new investigators considering applying fMRI to neuroscience of clinical studies:non-physicists wishing to more clearly understand the physical basis of fMRI. The book would also be useful to physics students wishing to taste a new application of NMR and understand how MRI is applied to brain functional mapping.
Features: After an introduction to MRI and to brain energy metabolism, blood flow, and cortical activation, the presentation provides a detailed tutorial review of MR image formation. This includes a modern review of diffusion imaging. Then, after 300 pages, the meat of the book is presented, the reviews of two approaches to functional brain mapping: perfusion imaging and blood oxygenation level dependent (BOLD) imaging. It is notable that perfusion imaging and BOLD imaging get fairly equal treatment. This broader outlook is deliberate and is a strength of the book. On the downside, as a result of the broad coverage, the current bread and butter fMRI, BOLD imaging, is not discussed in detail until page 389 (out of about under 500 pages). In keeping with the emphasis on the physical rather than on the neurological or the psychological, many details of experimental technique such as paradigm design in relation to specific neuroscience hypotheses are not covered. A researcher looking for the nuts-and-bolts of performing fMRI experiments will need to go elsewhere. The strength of the book is a systematic single author treatment of the basis of fMRI physics accessible to a wide readership. Figures do not use color but are clear. The mathematical component is minimized in the main narrative, but is not ignored, appearing in boxed sections.
Assessment: I recommend this book for its up-to-date, accessible, and conceptual introduction to the field. The accessibility is helped by the book's consistent style and lack of overlap (aided by the single author), which will help make the book suitable for class teaching and self-tutoring. Multiauthor treatments include Functional MRI, by Moonen and Bandettini (Springer Verlag, 2000), Functional MRI: An Introduction to Methods, by Jezzard et al. (Oxford University Press, 2001), and Handbook of Functional Neuroimaging of Cognition, by Cabeza and Kingstone (MIT Press, 2001).
From The Critics
Functional magnetic resonance imaging (fMRI) is now a standard tool for mapping activation patterns in the human brain (a highly interdisciplinary field involving neuroscientists and physicists as well as clinicians). Buxton (radiology, magnetic resonance research, U. of California, San Diego) introduces basic principles as well as underlying physics and physiology, discusses newer techniques such as arterial spin labeling and diffusion tensor imaging, relates fMRI to other imaging techniques, and presents a guide to the statistical analysis of fMRI data. A CD-ROM is included in the package under ISBN 0-521-00274-5; the book is sold separately under ISBN 0-521-58113-3. Annotation c. Book News, Inc., Portland, OR (

3 Stars from Doody
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Product Details

  • ISBN-13: 9780521002752
  • Publisher: Cambridge University Press
  • Publication date: 3/28/2002
  • Edition description: CD-ROM
  • Pages: 320
  • Product dimensions: 7.01 (w) x 8.98 (h) x 0.20 (d)

Table of Contents

Pt. I An Overview of Functional Magnetic Resonance Imaging 1
IA Introduction to Functional Neuroimaging 3
1 Energy Metabolism in the Brain 4
2 Cerebral Blood Flow 22
3 Brain Activation 41
IB Introduction to Functional Magnetic Resonance Imaging 63
4 Nuclear Magnetic Resonance 64
5 Magnetic Resonance Imaging 86
6 Imaging Functional Activity 104
Pt. II Principles of Magnetic Resonance Imaging 121
IIA The Nature of the Magnetic Resonance Signal 123
7 Basic Physics of Magnetism and NMR 124
8 Relaxation and Contrast in MRI 155
9 Diffusion and the MR Signal 185
IIB Magnetic Resonance Imaging 217
10 Mapping the MR Signal 218
11 MRI Techniques 249
12 Noise and Artifacts in MR Images 274
Pt. III Principles of Functional Magnetic Resonance Imaging 304
IIIA Perfusion Imaging 309
13 Principles of Tracer Kinetics 310
14 Contrast Agent Techniques 330
15 Arterial Spin Labeling Techniques 351
IIIB Blood Oxygenation Level Dependent Imaging 389
16 The Nature of the Blood Oxygenation Level Dependent Effect 390
17 Mapping Brain Activation with BOLD-fMRI 417
18 Statistical Analysis of BOLD Data 445
19 Efficient Design of BOLD Experiments 473
App The Physics of NMR 493
Index 511
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