Introduction to Genomic Signal Processing with Control

Hardcover (Print)
Buy New
Buy New from BN.com
$122.42
Used and New from Other Sellers
Used and New from Other Sellers
from $99.95
Usually ships in 1-2 business days
(Save 31%)
Other sellers (Hardcover)
  • All (8) from $99.95   
  • New (4) from $125.85   
  • Used (4) from $99.95   

Overview

Studying large sets of genes and their collective function requires tools that can easily handle huge amounts of information. Recent research indicates that engineering approaches for prediction, signal processing, and control are well suited for studying multivariate interactions. A tutorial guide to the current engineering research in genomics, Introduction to Genomic Signal Processing with Control provides a state-of-the-art account of the use of control theory to obtain intervention strategies for gene regulatory networks.

The book builds up the necessary molecular biology background with a basic review of organic chemistry and an introduction of DNA, RNA, and proteins, followed by a description of the processes of transcription and translation and the genetic code that is used to carry out the latter. It discusses control of gene expression, introduces genetic engineering tools such as microarrays and PCR, and covers cell cycle control and tissue renewal in multi-cellular organisms.

The authors then delineate how the engineering approaches of classification and clustering are appropriate for carrying out gene-based disease classification. This leads naturally to expression prediction, which in turn leads to genetic regulatory networks. The book concludes with a discussion of control approaches that can be used to alter the behavior of such networks in the hope that this alteration will move the network from a diseased state to a disease-free state.

Written by recognized leaders in this emerging field, the book provides the exact amount of molecular biology required to understand the engineering applications. It is a self-contained resource that spans the diverse disciplines of molecular biology and electrical engineering.

Read More Show Less

Product Details

  • ISBN-13: 9780849371981
  • Publisher: CRC Press
  • Publication date: 12/1/2006
  • Edition description: New Edition
  • Pages: 288
  • Product dimensions: 6.20 (w) x 9.30 (h) x 0.90 (d)

Table of Contents

INTRODUCTION

REVIEW OF ORGANIC CHEMISTRY
Electrovalent and Covalent Bonds
Some Chemical Bonds and Groups Commonly Encountered in Biological Molecules
Building Blocks for Common Organic Molecules

ENERGY CONSIDERATIONS IN BIOCHEMICAL REACTIONS
Some Common Biochemical Reactions
Role of Enzymes
Feasibility of Chemical Reactions
Activated Carrier Molecules and Their Role in Biosynthesis

PROTEINS
Protein Structure and Function
Levels of Organization in Proteins
Protein Ligand Interactions
Isolating Proteins from Cells
Separating a Mixture of Proteins
Protein Structure Determination
Proteins That Are Enzymes

DNA

TRANSCRIPTION AND TRANSLATION
Transcription
Translation

CHROMOSOMES AND GENE REGULATION
Organization of DNA into Chromosomes
Gene Regulation

GENETIC VARIATION
Genetic Variation in Bacteria
Sources of Genetic Change in Eucaryotic Genomes

DNA TECHNOLOGY
Techniques for Analyzing DNA Molecules
Nucleic Acid Hybridization and Associated Techniques
Construction of Human Genomic and cDNA Libraries
Polymerase Chain Reaction (PCR)
Genetic Engineering

CELL DIVISION
Mitosis and Cytokinesis
Meiosis

CELL CYCLE CONTROL, CELL DEATH AND CANCER
Cyclin-Dependent Kinases and Their Role
Control of Cell Numbers in Multicellular Organisms
Programmed Cell Death
Cancer as the Breakdown of Cell Cycle Control

EXPRESSION MICROARRAYS
cDNA Microarrays
Synthetic Oligonucleotide Arrays

CLASSIFICATION
Classifier Design
Feature Selection
Error Estimation

CLUSTERING
Examples of Clustering Algorithms
Clustering Accuracy
Cluster Validation

GENETIC REGULATORY NETWORKS
Nonlinear Dynamical Modeling of Gene Networks
Boolean Networks
Probabilistic Boolean Networks
Network Inference

INTERVENTION
PBN Notation
Intervention by Flipping the Status of a Single Gene
Intervention to Alter the Steady-State Behavior

EXTERNAL INTERVENTION BASED ON OPTIMAL CONTROL THEORY
Finite Horizon Control
External Intervention in the Imperfect Information Case
External Intervention in the Context-Sensitive Case
External Intervention for a Family of Boolean Networks
External Intervention in the Infinite Horizon Case
Concluding Remarks
References
Index

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)