Introduction to Pharmacokinetics and Pharmacodynamics: The Quantitative Basis of Drug Therapy / Edition 1

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This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

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Editorial Reviews

Doody's Review Service
Reviewer: Olga M. Klibanov, PharmD (Temple University School of Pharmacy)
Description: This introductory textbook highlights basic principles of pharmacokinetics/pharmacodynamics (PK/PD). It is most appropriate for pharmacy students in their first semester of pharmacokinetics, as well as for anyone who wants a basic knowledge base of pharmacology and PK/PD principles of drugs.
Purpose: The purpose is to introduce the basic principles of drug metabolism and response. The book meets these worthy objectives.
Audience: According to the author, the audience for this book includes students and practitioners of pharmacy and medicine, as well as other health professionals, who need to understand the principles upon which quantitative decisions in drug therapy are based.
Features: The best feature of this book is the abundance of illustrations that help readers better comprehend the text. Also, the examples of medications described in tables help readers apply the basic concepts of PK/PD to actual drugs.
Assessment: The useful book is of high quality. There are several other books on the market describing basic principles of PK/PD, but this one is updated and has better illustrations.
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Product Details

  • ISBN-13: 9780781751490
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 2/1/2006
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 336
  • Sales rank: 1,218,169

Table of Contents

Ch. 1 Opening comments 1
Sect. I Basic considerations 13
Ch. 2 Input-exposure relationships 15
Ch. 3 Exposure-response relationships 27
Sect. II Exposure and response after a single dose 43
Ch. 4 Membranes : a determining factor 45
Ch. 5 Disposition following intravenous bolus 63
Ch. 6 Extravascular dose and systemic absorption 105
Ch. 7 Response following a single dose 137
Sect. III Therapeutic regimens 155
Ch. 8 Therapeutic window 157
Ch. 9 Constant-rate regimens 169
Ch. 10 Multiple-dose regimens 189
Sect. IV Individualization 217
Ch. 11 Variability 219
Ch. 12 Initiating and managing therapy 249
Nonproprietary and brand names of drugs in text and illustrations
App. A Assessment of AUC
App. B Ionization and the pH partition hypothesis
App. C Amount of drug in the body on accumulation to plateau
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